Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children

Holm Jens-Christian; Gamborg Michael; Ward Leigh; Ibsen Karsten Kaas; Gammeltoft Ibsen; Sørensen Thorkild I.A.; Heitmann Berit Lilienthal; Jens-Christian Holm; Michael Gamborg; Leigh Ward; Karsten Kaas Ibsen; Steen Gammeltoft; Thorkild I A Sørensen; Berit Lilienthal Heitmann

doi:10.1159/000226619

Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children

Holm Jens-Christian, Gamborg Michael, Ward Leigh, Ibsen Karsten Kaas, Gammeltoft Ibsen, Sørensen Thorkild I.A., Heitmann Berit Lilienthal, Jens-Christian Holm, Michael Gamborg, Leigh Ward, Karsten Kaas Ibsen, Steen Gammeltoft, Thorkild I A Sørensen, Berit Lilienthal Heitmann

7 Citations (Scopus)

Abstract

Objective: This study assessed if lower than predicted serum leptin concentrations seen during weight loss persisted during weight regain, with possible implications for weight control. Methods: 115 children were investigated during a 12-week weight loss program. 90 children completed the program, and 68 children entered a follow-up program spanning 28 months. Measurements were performed at baseline and day 82 as well as at months 10, 16, and 28. Height, weight, body composition, Tanner stages, testicular size, and serum concentrations of leptin, and insulin were measured at all time points. Results: Children with the greatest increases in BMI standard deviation score (SDS) exhibited the largest leptin increments. The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship. Conclusion: Proportional increases of leptin and BMI SDS during weight regain suggests an intact leptin response during re-accumulation of fat. Following the pronounced reduction of leptin during weight loss, leptin levels were restored during weight regain to an extent where leptin levels were comparable with those at baseline, which is indicative of an inefficient lipostatic control exerted by leptin during weight regain.

Original language	English
Journal	Obesity Facts
Volume	2
Issue number	4
Pages (from-to)	243-248
Number of pages	5
ISSN	1662-4025
DOIs	https://doi.org/10.1159/000226619
Publication status	Published - 2009

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Jens-Christian, H., Michael, G., Leigh, W., Kaas, I. K., Ibsen, G., I.A., S. T., Lilienthal, H. B., Holm, J.-C., Gamborg, M., Ward, L., Ibsen, K. K., Gammeltoft, S., Sørensen, T. I. A., & Heitmann, B. L. (2009). Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children. Obesity Facts, 2(4), 243-248. https://doi.org/10.1159/000226619

@article{8d20d3c073c311df928f000ea68e967b,

title = "Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children",

abstract = "Objective: This study assessed if lower than predicted serum leptin concentrations seen during weight loss persisted during weight regain, with possible implications for weight control. Methods: 115 children were investigated during a 12-week weight loss program. 90 children completed the program, and 68 children entered a follow-up program spanning 28 months. Measurements were performed at baseline and day 82 as well as at months 10, 16, and 28. Height, weight, body composition, Tanner stages, testicular size, and serum concentrations of leptin, and insulin were measured at all time points. Results: Children with the greatest increases in BMI standard deviation score (SDS) exhibited the largest leptin increments. The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship. Conclusion: Proportional increases of leptin and BMI SDS during weight regain suggests an intact leptin response during re-accumulation of fat. Following the pronounced reduction of leptin during weight loss, leptin levels were restored during weight regain to an extent where leptin levels were comparable with those at baseline, which is indicative of an inefficient lipostatic control exerted by leptin during weight regain.",

author = "Holm Jens-Christian and Gamborg Michael and Ward Leigh and Kaas, {Ibsen Karsten} and Gammeltoft Ibsen and I.A., {S{\o}rensen Thorkild} and Lilienthal, {Heitmann Berit} and Jens-Christian Holm and Michael Gamborg and Leigh Ward and Ibsen, {Karsten Kaas} and Steen Gammeltoft and S{\o}rensen, {Thorkild I A} and Heitmann, {Berit Lilienthal}",

note = "Copyright {\textcopyright} 2009 S. Karger AG, Basel.",

year = "2009",

doi = "10.1159/000226619",

language = "English",

volume = "2",

pages = "243--248",

journal = "Obesity Facts",

issn = "1662-4025",

publisher = "S Karger AG",

number = "4",

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TY - JOUR

T1 - Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children

AU - Jens-Christian, Holm

AU - Michael, Gamborg

AU - Leigh, Ward

AU - Kaas, Ibsen Karsten

AU - Ibsen, Gammeltoft

AU - I.A., Sørensen Thorkild

AU - Lilienthal, Heitmann Berit

AU - Holm, Jens-Christian

AU - Gamborg, Michael

AU - Ward, Leigh

AU - Ibsen, Karsten Kaas

AU - Gammeltoft, Steen

AU - Sørensen, Thorkild I A

AU - Heitmann, Berit Lilienthal

PY - 2009

Y1 - 2009

N2 - Objective: This study assessed if lower than predicted serum leptin concentrations seen during weight loss persisted during weight regain, with possible implications for weight control. Methods: 115 children were investigated during a 12-week weight loss program. 90 children completed the program, and 68 children entered a follow-up program spanning 28 months. Measurements were performed at baseline and day 82 as well as at months 10, 16, and 28. Height, weight, body composition, Tanner stages, testicular size, and serum concentrations of leptin, and insulin were measured at all time points. Results: Children with the greatest increases in BMI standard deviation score (SDS) exhibited the largest leptin increments. The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship. Conclusion: Proportional increases of leptin and BMI SDS during weight regain suggests an intact leptin response during re-accumulation of fat. Following the pronounced reduction of leptin during weight loss, leptin levels were restored during weight regain to an extent where leptin levels were comparable with those at baseline, which is indicative of an inefficient lipostatic control exerted by leptin during weight regain.

AB - Objective: This study assessed if lower than predicted serum leptin concentrations seen during weight loss persisted during weight regain, with possible implications for weight control. Methods: 115 children were investigated during a 12-week weight loss program. 90 children completed the program, and 68 children entered a follow-up program spanning 28 months. Measurements were performed at baseline and day 82 as well as at months 10, 16, and 28. Height, weight, body composition, Tanner stages, testicular size, and serum concentrations of leptin, and insulin were measured at all time points. Results: Children with the greatest increases in BMI standard deviation score (SDS) exhibited the largest leptin increments. The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship. Conclusion: Proportional increases of leptin and BMI SDS during weight regain suggests an intact leptin response during re-accumulation of fat. Following the pronounced reduction of leptin during weight loss, leptin levels were restored during weight regain to an extent where leptin levels were comparable with those at baseline, which is indicative of an inefficient lipostatic control exerted by leptin during weight regain.

U2 - 10.1159/000226619

DO - 10.1159/000226619

M3 - Journal article

SN - 1662-4025

VL - 2

SP - 243

EP - 248

JO - Obesity Facts

JF - Obesity Facts

IS - 4

ER -

Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children

Abstract

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