Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy

TY - JOUR

T1 - Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction

T2 - the IBIS-4 (integrated biomarker and imaging study) substudy

AU - Taniwaki, Masanori

AU - Radu, Maria D

AU - Garcia-Garcia, Hector M

AU - Heg, Dik

AU - Kelbæk, Henning

AU - Holmvang, Lene

AU - Moschovitis, Aris

AU - Noble, Stephane

AU - Pedrazzini, Giovanni

AU - Saunamäki, Kari

AU - Dijkstra, Jouke

AU - Landmesser, Ulf

AU - Wenaweser, Peter

AU - Meier, Bernhard

AU - Stefanini, Giulio G

AU - Roffi, Marco

AU - Lüscher, Thomas F

AU - Windecker, Stephan

AU - Räber, Lorenz

PY - 2015/6/29

Y1 - 2015/6/29

N2 - We assessed the feasibility and the procedural and long-term safety of intracoronary (i.c) imaging for documentary purposes with optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary PCI in the setting of IBIS-4 study. IBIS4 (NCT00962416) is a prospective cohort study conducted at five European centers including 103 STEMI patients who underwent serial three-vessel coronary imaging during primary PCI and at 13 months. The feasibility parameter was successful imaging, defined as the number of pullbacks suitable for analysis. Safety parameters included the frequency of peri-procedural complications, and major adverse cardiac events (MACE), a composite of cardiac death, myocardial infarction (MI) and any clinically-indicated revascularization at 2 years. Clinical outcomes were compared with the results from a cohort of 485 STEMI patients undergoing primary PCI without additional imaging. Imaging of the infarct-related artery at baseline (and follow-up) was successful in 92.2% (96.6%) of patients using OCT and in 93.2% (95.5%) using IVUS. Imaging of the non-infarct-related vessels was successful in 88.7% (95.6%) using OCT and in 90.5% (93.3%) using IVUS. Periprocedural complications occurred <2.0% of OCT and none during IVUS. There were no differences throughout 2 years between the imaging and control group in terms of MACE (16.7 vs. 13.3%, adjusted HR1.40, 95% CI 0.77-2.52, p = 0.27). Multi-modality three-vessel i.c. imaging in STEMI patients undergoing primary PCI is consistent a high degree of success and can be performed safely without impact on cardiovascular events at long-term follow-up.

AB - We assessed the feasibility and the procedural and long-term safety of intracoronary (i.c) imaging for documentary purposes with optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary PCI in the setting of IBIS-4 study. IBIS4 (NCT00962416) is a prospective cohort study conducted at five European centers including 103 STEMI patients who underwent serial three-vessel coronary imaging during primary PCI and at 13 months. The feasibility parameter was successful imaging, defined as the number of pullbacks suitable for analysis. Safety parameters included the frequency of peri-procedural complications, and major adverse cardiac events (MACE), a composite of cardiac death, myocardial infarction (MI) and any clinically-indicated revascularization at 2 years. Clinical outcomes were compared with the results from a cohort of 485 STEMI patients undergoing primary PCI without additional imaging. Imaging of the infarct-related artery at baseline (and follow-up) was successful in 92.2% (96.6%) of patients using OCT and in 93.2% (95.5%) using IVUS. Imaging of the non-infarct-related vessels was successful in 88.7% (95.6%) using OCT and in 90.5% (93.3%) using IVUS. Periprocedural complications occurred <2.0% of OCT and none during IVUS. There were no differences throughout 2 years between the imaging and control group in terms of MACE (16.7 vs. 13.3%, adjusted HR1.40, 95% CI 0.77-2.52, p = 0.27). Multi-modality three-vessel i.c. imaging in STEMI patients undergoing primary PCI is consistent a high degree of success and can be performed safely without impact on cardiovascular events at long-term follow-up.

KW - Aged

KW - Cardiovascular Agents

KW - Coronary Vessels

KW - Drug-Eluting Stents

KW - Europe

KW - Feasibility Studies

KW - Female

KW - Humans

KW - Male

KW - Metals

KW - Middle Aged

KW - Multimodal Imaging

KW - Myocardial Infarction

KW - Percutaneous Coronary Intervention

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Prosthesis Design

KW - Risk Factors

KW - Sirolimus

KW - Time Factors

KW - Tomography, Optical Coherence

KW - Treatment Outcome

KW - Ultrasonography, Interventional

U2 - 10.1007/s10554-015-0631-0

DO - 10.1007/s10554-015-0631-0

M3 - Journal article

C2 - 25721728

SN - 1569-5794

VL - 31

SP - 915

EP - 926

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

IS - 5

ER -