Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study

Emil Loldrup Fosbøl; Marie Seibaek; Bente Brendorp; Daniel Vega Moller; Jens Jakob Thune; Gunnar H Gislason; Christian Torp-Pedersen; Lars Køber; Danish Investigations and Arrhythmia ON Dofetilide  Study Group; Emil Loldrup Fosbøl; Marie Seibaek; Bente Brendorp; Daniel Vega Møller; Jens Jakob Thune; Gunnar H Gislason; Christian Torp-Pedersen; Lars Køber; Danish Investigations and Arrhythmia ON Dofetilide  Study Group

doi:10.1016/j.ijcard.2008.11.084

Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study

Emil Loldrup Fosbøl, Marie Seibaek, Bente Brendorp, Daniel Vega Moller, Jens Jakob Thune, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Danish Investigations and Arrhythmia ON Dofetilide Study Group, Emil Loldrup Fosbøl, Marie Seibaek, Bente Brendorp, Daniel Vega Møller, Jens Jakob Thune, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Danish Investigations and Arrhythmia ON Dofetilide Study Group

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Abstract

Background: Elevated resting heart rate is associated with increased mortality in a variety of cardiac diseases, but comparisons between different clinical settings are lacking. We investigated the long-term prognostic importance of resting heart rate in patients hospitalized with left ventricular dysfunction in connection with either heart failure (HF) or myocardial infarction (MI). Methods: In the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study; patients with left ventricular dysfunction were randomized to Dofetilide (class III antiarrhythmic drug) or placebo. One part of the study enrolled 1518 patients with HF and another 1510 patients with MI. Mortality analyses were performed using multivariable adjusted Cox proportional hazard models. Results: During 10 years of follow-up, 1076 (72%) patients with MI and 1336 (89%) patients with HF died. In multivariable adjusted models, every increment in baseline heart rate of 10 bpm was associated with an increase in mortality in both MI-patients (hazard ratio, 1.14; 95%- confidence interval (CI): 1.09-1.19; P<.0001) and HF-patients (hazard ratio, 1.10; CI: 1.06-1.15; P<.0001). The importance of resting heart rate on short-term prognosis was stronger in the MI patients compared to the HF patients (P<.0001 for interaction). There was no interaction between heart rate and β-blockade, and inclusion of β-blockade in the model did not change the results. Conclusions: Resting heart rate was independently associated with increased risk of overall mortality. The prognostic importance of resting heart rate is stronger in patients with MI compared to patients with HF, especially in the short term.

Original language	English
Journal	International Journal of Cardiology
Volume	140
Issue number	3
Pages (from-to)	279-86
Number of pages	8
ISSN	0167-5273
DOIs	https://doi.org/10.1016/j.ijcard.2008.11.084
Publication status	Published - 30 Apr 2010

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Fosbøl, E. L., Seibaek, M., Brendorp, B., Moller, D. V., Thune, J. J., Gislason, G. H., Torp-Pedersen, C., Køber, L., Danish Investigations and Arrhythmia ON Dofetilide Study Group, Fosbøl, E. L., Seibaek, M., Brendorp, B., Møller, D. V., Thune, J. J., Gislason, G. H., Torp-Pedersen, C., Køber, L., & Danish Investigations and Arrhythmia ON Dofetilide Study Group (2010). Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study. International Journal of Cardiology, 140(3), 279-86. https://doi.org/10.1016/j.ijcard.2008.11.084

Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study. / Fosbøl, Emil Loldrup; Seibaek, Marie; Brendorp, Bente et al.

In: International Journal of Cardiology, Vol. 140, No. 3, 30.04.2010, p. 279-86.

Research output: Contribution to journal › Journal article › Research › peer-review

Fosbøl, EL, Seibaek, M, Brendorp, B, Moller, DV, Thune, JJ, Gislason, GH , Torp-Pedersen, C , Køber, L, Danish Investigations and Arrhythmia ON Dofetilide Study Group, Fosbøl, EL, Seibaek, M, Brendorp, B, Møller, DV, Thune, JJ, Gislason, GH , Torp-Pedersen, C , Køber, L & Danish Investigations and Arrhythmia ON Dofetilide Study Group 2010, 'Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study', International Journal of Cardiology, vol. 140, no. 3, pp. 279-86. https://doi.org/10.1016/j.ijcard.2008.11.084

@article{6186d7c0c56511df825b000ea68e967b,

title = "Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study",

abstract = "Background: Elevated resting heart rate is associated with increased mortality in a variety of cardiac diseases, but comparisons between different clinical settings are lacking. We investigated the long-term prognostic importance of resting heart rate in patients hospitalized with left ventricular dysfunction in connection with either heart failure (HF) or myocardial infarction (MI). Methods: In the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study; patients with left ventricular dysfunction were randomized to Dofetilide (class III antiarrhythmic drug) or placebo. One part of the study enrolled 1518 patients with HF and another 1510 patients with MI. Mortality analyses were performed using multivariable adjusted Cox proportional hazard models. Results: During 10 years of follow-up, 1076 (72%) patients with MI and 1336 (89%) patients with HF died. In multivariable adjusted models, every increment in baseline heart rate of 10 bpm was associated with an increase in mortality in both MI-patients (hazard ratio, 1.14; 95%- confidence interval (CI): 1.09-1.19; P<.0001) and HF-patients (hazard ratio, 1.10; CI: 1.06-1.15; P<.0001). The importance of resting heart rate on short-term prognosis was stronger in the MI patients compared to the HF patients (P<.0001 for interaction). There was no interaction between heart rate and β-blockade, and inclusion of β-blockade in the model did not change the results. Conclusions: Resting heart rate was independently associated with increased risk of overall mortality. The prognostic importance of resting heart rate is stronger in patients with MI compared to patients with HF, especially in the short term.",

author = "Fosb{\o}l, {Emil Loldrup} and Marie Seibaek and Bente Brendorp and Moller, {Daniel Vega} and Thune, {Jens Jakob} and Gislason, {Gunnar H} and Christian Torp-Pedersen and Lars K{\o}ber and {Danish Investigations and Arrhythmia ON Dofetilide Study Group} and Fosb{\o}l, {Emil Loldrup} and Marie Seibaek and Bente Brendorp and M{\o}ller, {Daniel Vega} and Thune, {Jens Jakob} and Gislason, {Gunnar H} and Christian Torp-Pedersen and Lars K{\o}ber and Torp-Pedersen, {Christian Tobias}",

note = "Keywords: Aged; Aged, 80 and over; Denmark; Female; Follow-Up Studies; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Prognosis; Proportional Hazards Models; Survival Rate; Ventricular Dysfunction, Left",

year = "2010",

month = apr,

day = "30",

doi = "10.1016/j.ijcard.2008.11.084",

language = "English",

volume = "140",

pages = "279--86",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "3",

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TY - JOUR

T1 - Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study

AU - Fosbøl, Emil Loldrup

AU - Seibaek, Marie

AU - Brendorp, Bente

AU - Moller, Daniel Vega

AU - Thune, Jens Jakob

AU - Gislason, Gunnar H

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Danish Investigations and Arrhythmia ON Dofetilide Study Group

AU - Fosbøl, Emil Loldrup

AU - Seibaek, Marie

AU - Brendorp, Bente

AU - Møller, Daniel Vega

AU - Thune, Jens Jakob

AU - Gislason, Gunnar H

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Danish Investigations and Arrhythmia ON Dofetilide Study Group

N1 - Keywords: Aged; Aged, 80 and over; Denmark; Female; Follow-Up Studies; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Prognosis; Proportional Hazards Models; Survival Rate; Ventricular Dysfunction, Left

PY - 2010/4/30

Y1 - 2010/4/30

N2 - Background: Elevated resting heart rate is associated with increased mortality in a variety of cardiac diseases, but comparisons between different clinical settings are lacking. We investigated the long-term prognostic importance of resting heart rate in patients hospitalized with left ventricular dysfunction in connection with either heart failure (HF) or myocardial infarction (MI). Methods: In the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study; patients with left ventricular dysfunction were randomized to Dofetilide (class III antiarrhythmic drug) or placebo. One part of the study enrolled 1518 patients with HF and another 1510 patients with MI. Mortality analyses were performed using multivariable adjusted Cox proportional hazard models. Results: During 10 years of follow-up, 1076 (72%) patients with MI and 1336 (89%) patients with HF died. In multivariable adjusted models, every increment in baseline heart rate of 10 bpm was associated with an increase in mortality in both MI-patients (hazard ratio, 1.14; 95%- confidence interval (CI): 1.09-1.19; P<.0001) and HF-patients (hazard ratio, 1.10; CI: 1.06-1.15; P<.0001). The importance of resting heart rate on short-term prognosis was stronger in the MI patients compared to the HF patients (P<.0001 for interaction). There was no interaction between heart rate and β-blockade, and inclusion of β-blockade in the model did not change the results. Conclusions: Resting heart rate was independently associated with increased risk of overall mortality. The prognostic importance of resting heart rate is stronger in patients with MI compared to patients with HF, especially in the short term.

AB - Background: Elevated resting heart rate is associated with increased mortality in a variety of cardiac diseases, but comparisons between different clinical settings are lacking. We investigated the long-term prognostic importance of resting heart rate in patients hospitalized with left ventricular dysfunction in connection with either heart failure (HF) or myocardial infarction (MI). Methods: In the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study; patients with left ventricular dysfunction were randomized to Dofetilide (class III antiarrhythmic drug) or placebo. One part of the study enrolled 1518 patients with HF and another 1510 patients with MI. Mortality analyses were performed using multivariable adjusted Cox proportional hazard models. Results: During 10 years of follow-up, 1076 (72%) patients with MI and 1336 (89%) patients with HF died. In multivariable adjusted models, every increment in baseline heart rate of 10 bpm was associated with an increase in mortality in both MI-patients (hazard ratio, 1.14; 95%- confidence interval (CI): 1.09-1.19; P<.0001) and HF-patients (hazard ratio, 1.10; CI: 1.06-1.15; P<.0001). The importance of resting heart rate on short-term prognosis was stronger in the MI patients compared to the HF patients (P<.0001 for interaction). There was no interaction between heart rate and β-blockade, and inclusion of β-blockade in the model did not change the results. Conclusions: Resting heart rate was independently associated with increased risk of overall mortality. The prognostic importance of resting heart rate is stronger in patients with MI compared to patients with HF, especially in the short term.

U2 - 10.1016/j.ijcard.2008.11.084

DO - 10.1016/j.ijcard.2008.11.084

M3 - Journal article

C2 - 19095316

SN - 0167-5273

VL - 140

SP - 279

EP - 286

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 3

ER -

Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study

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