Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial

Anne Kaltoft; Henning Kelbaek; Leif Thuesen; Jens Flensted Lassen; Peter Clemmensen; Lene Kløvgaard; Thomas Engstrøm; Hans Erik Bøtker; Kari Saunamäki; Lars Romer Krusell; Erik Jørgensen; Hans-Henrik Tilsted; Evald Høj Christiansen; Jan Ravkilde; Lars Køber; Klaus F Kofoed; Christian Juhl Terkelsen; Steffen Helqvist

doi:http://dx.doi.org/10.1016/j.jacc.2010.05.009

Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial

Anne Kaltoft, Henning Kelbaek, Leif Thuesen, Jens Flensted Lassen, Peter Clemmensen, Lene Kløvgaard, Thomas Engstrøm, Hans Erik Bøtker, Kari Saunamäki, Lars Romer Krusell, Erik Jørgensen, Hans-Henrik Tilsted, Evald Høj Christiansen, Jan Ravkilde, Lars Køber, Klaus F Kofoed, Christian Juhl Terkelsen, Steffen Helqvist

65 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to compare long-term clinical outcomes after implantation of drug-eluting stents (DES) and bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI). Background: The evidence of long-term efficacy and safety after implantation of DES in patients with complex lesions is scarce. Methods: We randomly assigned 626 patients with STEMI referred within 12 h to have a DES or a BMS implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Results: At 3 years, target lesion revascularization was 6.1% in the DES group compared with 16.3% in the BMS group (p < 0.001), and the rate of major adverse cardiac events was 11.5% versus 18.2%, respectively (p = 0.02). Whereas all-cause mortality did not differ significantly, the rate of cardiac death was higher in the DES group, 6.1% versus 1.9% for the BMS group (p = 0.01). The occurrence of reinfarction, stroke, and stent thrombosis was similar. Conclusions: Implantation of DES in patients with STEMI reduces the long-term rate of major adverse cardiac events compared with BMS, but patients with DES had a higher risk of cardiac death not attributed to myocardial infarction or stent thrombosis. (Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction [DEDICATION]; NCT00192868)

Original language	English
Journal	Journal of the American College of Cardiology
Volume	56
Issue number	8
Pages (from-to)	641-5
Number of pages	5
ISSN	0735-1097
DOIs	https://doi.org/10.1016/j.jacc.2010.05.009
Publication status	Published - 17 Aug 2010

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Kaltoft, A., Kelbaek, H., Thuesen, L., Lassen, J. F., Clemmensen, P., Kløvgaard, L., Engstrøm, T., Bøtker, H. E., Saunamäki, K., Krusell, L. R., Jørgensen, E., Tilsted, H-H., Christiansen, E. H., Ravkilde, J., Køber, L., Kofoed, K. F., Terkelsen, C. J., & Helqvist, S. (2010). Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial. Journal of the American College of Cardiology, 56(8), 641-5. https://doi.org/10.1016/j.jacc.2010.05.009

Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial. / Kaltoft, Anne; Kelbaek, Henning; Thuesen, Leif et al.

In: Journal of the American College of Cardiology, Vol. 56, No. 8, 17.08.2010, p. 641-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Kaltoft, A, Kelbaek, H, Thuesen, L, Lassen, JF, Clemmensen, P, Kløvgaard, L, Engstrøm, T, Bøtker, HE, Saunamäki, K, Krusell, LR, Jørgensen, E, Tilsted, H-H, Christiansen, EH, Ravkilde, J, Køber, L , Kofoed, KF, Terkelsen, CJ & Helqvist, S 2010, 'Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial', Journal of the American College of Cardiology, vol. 56, no. 8, pp. 641-5. https://doi.org/10.1016/j.jacc.2010.05.009

Kaltoft A, Kelbaek H, Thuesen L, Lassen JF, Clemmensen P, Kløvgaard L et al. Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial. Journal of the American College of Cardiology. 2010 Aug 17;56(8):641-5. doi: http://dx.doi.org/10.1016/j.jacc.2010.05.009

Kaltoft, Anne ; Kelbaek, Henning ; Thuesen, Leif et al. / Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial. In: Journal of the American College of Cardiology. 2010 ; Vol. 56, No. 8. pp. 641-5.

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title = "Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial",

abstract = "Objectives: The purpose of this study was to compare long-term clinical outcomes after implantation of drug-eluting stents (DES) and bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI). Background: The evidence of long-term efficacy and safety after implantation of DES in patients with complex lesions is scarce. Methods: We randomly assigned 626 patients with STEMI referred within 12 h to have a DES or a BMS implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Results: At 3 years, target lesion revascularization was 6.1% in the DES group compared with 16.3% in the BMS group (p < 0.001), and the rate of major adverse cardiac events was 11.5% versus 18.2%, respectively (p = 0.02). Whereas all-cause mortality did not differ significantly, the rate of cardiac death was higher in the DES group, 6.1% versus 1.9% for the BMS group (p = 0.01). The occurrence of reinfarction, stroke, and stent thrombosis was similar. Conclusions: Implantation of DES in patients with STEMI reduces the long-term rate of major adverse cardiac events compared with BMS, but patients with DES had a higher risk of cardiac death not attributed to myocardial infarction or stent thrombosis. (Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction [DEDICATION]; NCT00192868)",

author = "Anne Kaltoft and Henning Kelbaek and Leif Thuesen and Lassen, {Jens Flensted} and Peter Clemmensen and Lene Kl{\o}vgaard and Thomas Engstr{\o}m and B{\o}tker, {Hans Erik} and Kari Saunam{\"a}ki and Krusell, {Lars Romer} and Erik J{\o}rgensen and Hans-Henrik Tilsted and Christiansen, {Evald H{\o}j} and Jan Ravkilde and Lars K{\o}ber and Kofoed, {Klaus F} and Terkelsen, {Christian Juhl} and Steffen Helqvist",

year = "2010",

month = aug,

day = "17",

doi = "http://dx.doi.org/10.1016/j.jacc.2010.05.009",

language = "English",

volume = "56",

pages = "641--5",

journal = "Journal of the American College of Cardiology",

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T1 - Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: 3-year follow-up of the randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial

AU - Kaltoft, Anne

AU - Kelbaek, Henning

AU - Thuesen, Leif

AU - Lassen, Jens Flensted

AU - Clemmensen, Peter

AU - Kløvgaard, Lene

AU - Engstrøm, Thomas

AU - Bøtker, Hans Erik

AU - Saunamäki, Kari

AU - Krusell, Lars Romer

AU - Jørgensen, Erik

AU - Tilsted, Hans-Henrik

AU - Christiansen, Evald Høj

AU - Ravkilde, Jan

AU - Køber, Lars

AU - Kofoed, Klaus F

AU - Terkelsen, Christian Juhl

AU - Helqvist, Steffen

PY - 2010/8/17

Y1 - 2010/8/17

N2 - Objectives: The purpose of this study was to compare long-term clinical outcomes after implantation of drug-eluting stents (DES) and bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI). Background: The evidence of long-term efficacy and safety after implantation of DES in patients with complex lesions is scarce. Methods: We randomly assigned 626 patients with STEMI referred within 12 h to have a DES or a BMS implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Results: At 3 years, target lesion revascularization was 6.1% in the DES group compared with 16.3% in the BMS group (p < 0.001), and the rate of major adverse cardiac events was 11.5% versus 18.2%, respectively (p = 0.02). Whereas all-cause mortality did not differ significantly, the rate of cardiac death was higher in the DES group, 6.1% versus 1.9% for the BMS group (p = 0.01). The occurrence of reinfarction, stroke, and stent thrombosis was similar. Conclusions: Implantation of DES in patients with STEMI reduces the long-term rate of major adverse cardiac events compared with BMS, but patients with DES had a higher risk of cardiac death not attributed to myocardial infarction or stent thrombosis. (Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction [DEDICATION]; NCT00192868)

AB - Objectives: The purpose of this study was to compare long-term clinical outcomes after implantation of drug-eluting stents (DES) and bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI). Background: The evidence of long-term efficacy and safety after implantation of DES in patients with complex lesions is scarce. Methods: We randomly assigned 626 patients with STEMI referred within 12 h to have a DES or a BMS implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Results: At 3 years, target lesion revascularization was 6.1% in the DES group compared with 16.3% in the BMS group (p < 0.001), and the rate of major adverse cardiac events was 11.5% versus 18.2%, respectively (p = 0.02). Whereas all-cause mortality did not differ significantly, the rate of cardiac death was higher in the DES group, 6.1% versus 1.9% for the BMS group (p = 0.01). The occurrence of reinfarction, stroke, and stent thrombosis was similar. Conclusions: Implantation of DES in patients with STEMI reduces the long-term rate of major adverse cardiac events compared with BMS, but patients with DES had a higher risk of cardiac death not attributed to myocardial infarction or stent thrombosis. (Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction [DEDICATION]; NCT00192868)

U2 - http://dx.doi.org/10.1016/j.jacc.2010.05.009

DO - http://dx.doi.org/10.1016/j.jacc.2010.05.009

M3 - Journal article

SN - 0735-1097

VL - 56

SP - 641

EP - 645

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 8

ER -