Long-term internal thoracic artery bypass graft patency and geometry assessed by multidetector computed tomography

Mette Zacho; Sune Damgaard; Nikolaj Thomas Lilleoer; Henning Kelbaek; Daniel Steinbrüchel; Michael Bachmann Nielsen; Klaus Fuglsang Kofoed; Sune Damgaard; Thomas Nikolaj Lilleør

doi:10.1007/s10554-011-9962-7

Long-term internal thoracic artery bypass graft patency and geometry assessed by multidetector computed tomography

Mette Zacho, Sune Damgaard, Nikolaj Thomas Lilleoer, Henning Kelbaek, Daniel Steinbrüchel, Michael Bachmann Nielsen, Klaus Fuglsang Kofoed, Sune Damgaard, Thomas Nikolaj Lilleør

6 Citations (Scopus)

Abstract

The left internal thoracic artery (LITA) undergoes vascular remodelling when used for coronary artery bypass grafting. In this study we tested the hypothesis that the extent of the LITA remodelling late after coronary artery bypass grafting assessed by multidetector computed tomography is related to the severity of stenosis in the native coronary vessel. One hundred and forty-two patients who had undergone coronary artery bypass grafting including implantation of LITA as conduit to the left anterior descending artery were studied 5 years after surgery. Arterial graft patency and geometry was assessed with 64-slice multidetector computed tomography. Quantitative volumetric assessment of the LITA was performed to measure the average vessel lumen area (mm²/m²). The native coronary vessel subtended by the LITA was evaluated by multidetector computed tomography and defined as a high-grade stenosis patient group, when the diameter stenosis was>70% and an intermediate grade stenosis patient group when <70%. Among patients with intermediate-grade stenosis of the native vessel 11 out of 65 patients (17%) had a totally occluded LITA, as opposed to none among the 77 patients with a high-grade stenosis. In patients with intermediate-grade stenosis of the proximal native vessel, the LITA lumen area was 4.9 compared to 5.3 mm ²/m² in patients with a high-grade stenosis of the proximal native vessel (P = 0.0043). Lumen area of the LITA when used as a conduit in patients with coronary artery disease seems to be inversely correlated with the severity of disease in the native coronary vessel proximal to the anastomosis. Volumetric vessel multidetector computed tomography appears to be useful for evaluation of coronary bypass remodelling.

Original language	English
Journal	International Journal of Cardiovascular Imaging
Volume	28
Pages (from-to)	1577-83
ISSN	1569-5794
DOIs	https://doi.org/10.1007/s10554-011-9962-7
Publication status	Published - Aug 2012

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title = "Long-term internal thoracic artery bypass graft patency and geometry assessed by multidetector computed tomography",

abstract = "The left internal thoracic artery (LITA) undergoes vascular remodelling when used for coronary artery bypass grafting. In this study we tested the hypothesis that the extent of the LITA remodelling late after coronary artery bypass grafting assessed by multidetector computed tomography is related to the severity of stenosis in the native coronary vessel. One hundred and forty-two patients who had undergone coronary artery bypass grafting including implantation of LITA as conduit to the left anterior descending artery were studied 5 years after surgery. Arterial graft patency and geometry was assessed with 64-slice multidetector computed tomography. Quantitative volumetric assessment of the LITA was performed to measure the average vessel lumen area (mm2/m2). The native coronary vessel subtended by the LITA was evaluated by multidetector computed tomography and defined as a high-grade stenosis patient group, when the diameter stenosis was>70% and an intermediate grade stenosis patient group when <70%. Among patients with intermediate-grade stenosis of the native vessel 11 out of 65 patients (17%) had a totally occluded LITA, as opposed to none among the 77 patients with a high-grade stenosis. In patients with intermediate-grade stenosis of the proximal native vessel, the LITA lumen area was 4.9 compared to 5.3 mm 2/m2 in patients with a high-grade stenosis of the proximal native vessel (P = 0.0043). Lumen area of the LITA when used as a conduit in patients with coronary artery disease seems to be inversely correlated with the severity of disease in the native coronary vessel proximal to the anastomosis. Volumetric vessel multidetector computed tomography appears to be useful for evaluation of coronary bypass remodelling.",

author = "Mette Zacho and Sune Damgaard and Lilleoer, {Nikolaj Thomas} and Henning Kelbaek and Daniel Steinbr{\"u}chel and Nielsen, {Michael Bachmann} and Kofoed, {Klaus Fuglsang} and Sune Damgaard and Lille{\o}r, {Thomas Nikolaj}",

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doi = "10.1007/s10554-011-9962-7",

language = "English",

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AU - Zacho, Mette

AU - Damgaard, Sune

AU - Lilleoer, Nikolaj Thomas

AU - Kelbaek, Henning

AU - Steinbrüchel, Daniel

AU - Nielsen, Michael Bachmann

AU - Kofoed, Klaus Fuglsang

AU - Damgaard, Sune

AU - Lilleør, Thomas Nikolaj

PY - 2012/8

Y1 - 2012/8

N2 - The left internal thoracic artery (LITA) undergoes vascular remodelling when used for coronary artery bypass grafting. In this study we tested the hypothesis that the extent of the LITA remodelling late after coronary artery bypass grafting assessed by multidetector computed tomography is related to the severity of stenosis in the native coronary vessel. One hundred and forty-two patients who had undergone coronary artery bypass grafting including implantation of LITA as conduit to the left anterior descending artery were studied 5 years after surgery. Arterial graft patency and geometry was assessed with 64-slice multidetector computed tomography. Quantitative volumetric assessment of the LITA was performed to measure the average vessel lumen area (mm2/m2). The native coronary vessel subtended by the LITA was evaluated by multidetector computed tomography and defined as a high-grade stenosis patient group, when the diameter stenosis was>70% and an intermediate grade stenosis patient group when <70%. Among patients with intermediate-grade stenosis of the native vessel 11 out of 65 patients (17%) had a totally occluded LITA, as opposed to none among the 77 patients with a high-grade stenosis. In patients with intermediate-grade stenosis of the proximal native vessel, the LITA lumen area was 4.9 compared to 5.3 mm 2/m2 in patients with a high-grade stenosis of the proximal native vessel (P = 0.0043). Lumen area of the LITA when used as a conduit in patients with coronary artery disease seems to be inversely correlated with the severity of disease in the native coronary vessel proximal to the anastomosis. Volumetric vessel multidetector computed tomography appears to be useful for evaluation of coronary bypass remodelling.

AB - The left internal thoracic artery (LITA) undergoes vascular remodelling when used for coronary artery bypass grafting. In this study we tested the hypothesis that the extent of the LITA remodelling late after coronary artery bypass grafting assessed by multidetector computed tomography is related to the severity of stenosis in the native coronary vessel. One hundred and forty-two patients who had undergone coronary artery bypass grafting including implantation of LITA as conduit to the left anterior descending artery were studied 5 years after surgery. Arterial graft patency and geometry was assessed with 64-slice multidetector computed tomography. Quantitative volumetric assessment of the LITA was performed to measure the average vessel lumen area (mm2/m2). The native coronary vessel subtended by the LITA was evaluated by multidetector computed tomography and defined as a high-grade stenosis patient group, when the diameter stenosis was>70% and an intermediate grade stenosis patient group when <70%. Among patients with intermediate-grade stenosis of the native vessel 11 out of 65 patients (17%) had a totally occluded LITA, as opposed to none among the 77 patients with a high-grade stenosis. In patients with intermediate-grade stenosis of the proximal native vessel, the LITA lumen area was 4.9 compared to 5.3 mm 2/m2 in patients with a high-grade stenosis of the proximal native vessel (P = 0.0043). Lumen area of the LITA when used as a conduit in patients with coronary artery disease seems to be inversely correlated with the severity of disease in the native coronary vessel proximal to the anastomosis. Volumetric vessel multidetector computed tomography appears to be useful for evaluation of coronary bypass remodelling.

U2 - 10.1007/s10554-011-9962-7

DO - 10.1007/s10554-011-9962-7

M3 - Journal article

C2 - 22005892

SN - 1569-5794

VL - 28

SP - 1577

EP - 1583

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

ER -

Long-term internal thoracic artery bypass graft patency and geometry assessed by multidetector computed tomography

Abstract

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