Long non-coding RNAs as novel players in β cell function and type 1 diabetes

Aashiq H Mirza; Simranjeet Kaur; Flemming Pociot

doi:10.1186/s40246-017-0113-7

Long non-coding RNAs as novel players in β cell function and type 1 diabetes

Aashiq H Mirza, Simranjeet Kaur, Flemming Pociot

Department of Clinical Medicine

27 Citations (Scopus)

76 Downloads (Pure)

Abstract

Background

Long non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).

Main body of abstract

This review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.

Conclusion

We accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.

Original language	English
Article number	17
Journal	Human Genomics (Online)
Volume	11
Number of pages	10
ISSN	1479-7364
DOIs	https://doi.org/10.1186/s40246-017-0113-7
Publication status	Published - 4 Mar 2017

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10.1186/s40246-017-0113-7Licence: CC BY

Long non-coding RNAs as novel players in β cell function and type 1 diabetesFinal published version, 1.22 MBLicence: CC BY

Cite this

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abstract = "BackgroundLong non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.",

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AU - Mirza, Aashiq H

AU - Kaur, Simranjeet

AU - Pociot, Flemming

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Y1 - 2017/3/4

N2 - BackgroundLong non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.

AB - BackgroundLong non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.

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DO - 10.1186/s40246-017-0113-7

M3 - Review

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VL - 11

JO - Human Genomics (Online)

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Long non-coding RNAs as novel players in β cell function and type 1 diabetes

Abstract

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