Location of cardiac arrest and impact of pre-arrest chronic disease and medication use on survival

Asger Granfeldt; Mads Wissenberg; Steen Møller Hansen; Freddy K Lippert; Christian Torp-Pedersen; Erika Frischknecht Christensen; Christian Fynbo Christiansen

doi:10.1016/j.resuscitation.2017.02.026

Location of cardiac arrest and impact of pre-arrest chronic disease and medication use on survival

Asger Granfeldt, Mads Wissenberg, Steen Møller Hansen, Freddy K Lippert, Christian Torp-Pedersen, Erika Frischknecht Christensen, Christian Fynbo Christiansen

Department of Clinical Medicine

6 Citations (Scopus)

Abstract

INTRODUCTION: Cardiac arrest in a private location is associated with a higher mortality when compared to public location. Past studies have not accounted for pre-arrest factors such as chronic disease and medication.

AIM: To investigate whether the association between cardiac arrest in a private location and a higher mortality can be explained by differences in chronic diseases and medication.

METHODS: We identified 27,771 out-of-hospital cardiac arrest patients ≥18 years old from the Danish Cardiac Arrest Registry (2001-2012). Using National Registries, we identified pre-arrest chronic disease and medication. To investigate the importance of cardiac arrest related factors and chronic disease and medication use we performed adjusted Cox regression analyses during day 0-7 and day 8-365 following cardiac arrest to calculate hazard ratios (HR) for death.

RESULTS: Day 0-7: Un-adjusted HR for death day 0-7 was 1.21 (95%CI:1.18-1.25) in private compared to public location. When including cardiac arrest related factors HR for death was 1.09 (95%CI:1.06-1.12). Adding chronic disease and medication to the analysis changed HR for death to 1.08 (95%CI:1.05-1.12). 8-365 day: The un-adjusted HR for death day 8-365 was 1.70 (95% CI: 1.43-2.02) in private compared to public location. When including cardiac arrest related factors the HR decreased to 1.39 (95% CI: 1.14-1.68). Adding chronic disease and medication to the analysis changed HR for death to 1.27 (95% CI:1.04-1.54).

CONCLUSION: The higher mortality following cardiac arrest in a private location is partly explained by a higher prevalence of chronic disease and medication use in patients surviving until day 8.

Original language	English
Journal	Resuscitation
Volume	114
Pages (from-to)	113-120
Number of pages	8
ISSN	0300-9572
DOIs	https://doi.org/10.1016/j.resuscitation.2017.02.026
Publication status	Published - 1 May 2017

Keywords

Aged
Aged, 80 and over
Cardiopulmonary Resuscitation
Chronic Disease
Cohort Studies
Comorbidity
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Out-of-Hospital Cardiac Arrest
Population Surveillance
Proportional Hazards Models
Registries
Risk Factors
Time Factors
Journal Article

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10.1016/j.resuscitation.2017.02.026

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@article{5ec9f38cc2904ce981ceb74edcb22647,

title = "Location of cardiac arrest and impact of pre-arrest chronic disease and medication use on survival",

abstract = "INTRODUCTION: Cardiac arrest in a private location is associated with a higher mortality when compared to public location. Past studies have not accounted for pre-arrest factors such as chronic disease and medication.AIM: To investigate whether the association between cardiac arrest in a private location and a higher mortality can be explained by differences in chronic diseases and medication.METHODS: We identified 27,771 out-of-hospital cardiac arrest patients ≥18 years old from the Danish Cardiac Arrest Registry (2001-2012). Using National Registries, we identified pre-arrest chronic disease and medication. To investigate the importance of cardiac arrest related factors and chronic disease and medication use we performed adjusted Cox regression analyses during day 0-7 and day 8-365 following cardiac arrest to calculate hazard ratios (HR) for death.RESULTS: Day 0-7: Un-adjusted HR for death day 0-7 was 1.21 (95%CI:1.18-1.25) in private compared to public location. When including cardiac arrest related factors HR for death was 1.09 (95%CI:1.06-1.12). Adding chronic disease and medication to the analysis changed HR for death to 1.08 (95%CI:1.05-1.12). 8-365 day: The un-adjusted HR for death day 8-365 was 1.70 (95% CI: 1.43-2.02) in private compared to public location. When including cardiac arrest related factors the HR decreased to 1.39 (95% CI: 1.14-1.68). Adding chronic disease and medication to the analysis changed HR for death to 1.27 (95% CI:1.04-1.54).CONCLUSION: The higher mortality following cardiac arrest in a private location is partly explained by a higher prevalence of chronic disease and medication use in patients surviving until day 8.",

keywords = "Aged, Aged, 80 and over, Cardiopulmonary Resuscitation, Chronic Disease, Cohort Studies, Comorbidity, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Out-of-Hospital Cardiac Arrest, Population Surveillance, Proportional Hazards Models, Registries, Risk Factors, Time Factors, Journal Article",

author = "Asger Granfeldt and Mads Wissenberg and Hansen, {Steen M{\o}ller} and Lippert, {Freddy K} and Christian Torp-Pedersen and Christensen, {Erika Frischknecht} and Christiansen, {Christian Fynbo}",

year = "2017",

month = may,

day = "1",

doi = "10.1016/j.resuscitation.2017.02.026",

language = "English",

volume = "114",

pages = "113--120",

journal = "Resuscitation",

issn = "0300-9572",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Location of cardiac arrest and impact of pre-arrest chronic disease and medication use on survival

AU - Granfeldt, Asger

AU - Wissenberg, Mads

AU - Hansen, Steen Møller

AU - Lippert, Freddy K

AU - Torp-Pedersen, Christian

AU - Christensen, Erika Frischknecht

AU - Christiansen, Christian Fynbo

PY - 2017/5/1

Y1 - 2017/5/1

N2 - INTRODUCTION: Cardiac arrest in a private location is associated with a higher mortality when compared to public location. Past studies have not accounted for pre-arrest factors such as chronic disease and medication.AIM: To investigate whether the association between cardiac arrest in a private location and a higher mortality can be explained by differences in chronic diseases and medication.METHODS: We identified 27,771 out-of-hospital cardiac arrest patients ≥18 years old from the Danish Cardiac Arrest Registry (2001-2012). Using National Registries, we identified pre-arrest chronic disease and medication. To investigate the importance of cardiac arrest related factors and chronic disease and medication use we performed adjusted Cox regression analyses during day 0-7 and day 8-365 following cardiac arrest to calculate hazard ratios (HR) for death.RESULTS: Day 0-7: Un-adjusted HR for death day 0-7 was 1.21 (95%CI:1.18-1.25) in private compared to public location. When including cardiac arrest related factors HR for death was 1.09 (95%CI:1.06-1.12). Adding chronic disease and medication to the analysis changed HR for death to 1.08 (95%CI:1.05-1.12). 8-365 day: The un-adjusted HR for death day 8-365 was 1.70 (95% CI: 1.43-2.02) in private compared to public location. When including cardiac arrest related factors the HR decreased to 1.39 (95% CI: 1.14-1.68). Adding chronic disease and medication to the analysis changed HR for death to 1.27 (95% CI:1.04-1.54).CONCLUSION: The higher mortality following cardiac arrest in a private location is partly explained by a higher prevalence of chronic disease and medication use in patients surviving until day 8.

AB - INTRODUCTION: Cardiac arrest in a private location is associated with a higher mortality when compared to public location. Past studies have not accounted for pre-arrest factors such as chronic disease and medication.AIM: To investigate whether the association between cardiac arrest in a private location and a higher mortality can be explained by differences in chronic diseases and medication.METHODS: We identified 27,771 out-of-hospital cardiac arrest patients ≥18 years old from the Danish Cardiac Arrest Registry (2001-2012). Using National Registries, we identified pre-arrest chronic disease and medication. To investigate the importance of cardiac arrest related factors and chronic disease and medication use we performed adjusted Cox regression analyses during day 0-7 and day 8-365 following cardiac arrest to calculate hazard ratios (HR) for death.RESULTS: Day 0-7: Un-adjusted HR for death day 0-7 was 1.21 (95%CI:1.18-1.25) in private compared to public location. When including cardiac arrest related factors HR for death was 1.09 (95%CI:1.06-1.12). Adding chronic disease and medication to the analysis changed HR for death to 1.08 (95%CI:1.05-1.12). 8-365 day: The un-adjusted HR for death day 8-365 was 1.70 (95% CI: 1.43-2.02) in private compared to public location. When including cardiac arrest related factors the HR decreased to 1.39 (95% CI: 1.14-1.68). Adding chronic disease and medication to the analysis changed HR for death to 1.27 (95% CI:1.04-1.54).CONCLUSION: The higher mortality following cardiac arrest in a private location is partly explained by a higher prevalence of chronic disease and medication use in patients surviving until day 8.

KW - Aged

KW - Aged, 80 and over

KW - Cardiopulmonary Resuscitation

KW - Chronic Disease

KW - Cohort Studies

KW - Comorbidity

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Out-of-Hospital Cardiac Arrest

KW - Population Surveillance

KW - Proportional Hazards Models

KW - Registries

KW - Risk Factors

KW - Time Factors

KW - Journal Article

U2 - 10.1016/j.resuscitation.2017.02.026

DO - 10.1016/j.resuscitation.2017.02.026

M3 - Journal article

C2 - 28279694

SN - 0300-9572

VL - 114

SP - 113

EP - 120

JO - Resuscitation

JF - Resuscitation

ER -

Location of cardiac arrest and impact of pre-arrest chronic disease and medication use on survival

Abstract

Keywords

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