Local infiltration analgesia in urogenital prolapse surgery: a prospective randomized, double-blind, placebo-controlled study

TY - JOUR

T1 - Local infiltration analgesia in urogenital prolapse surgery: a prospective randomized, double-blind, placebo-controlled study

AU - Kristensen, Billy B

AU - Rasmussen, Yvonne H

AU - Agerlin, Marianne

AU - Topp, Monica W

AU - Ottesen Weincke, Marianne

AU - Kehlet, Henrik

N1 - © 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2011/10

Y1 - 2011/10

N2 - Objective. To evaluate the analgesic effect of high-volume infiltration analgesia in urogenital prolapse surgery and provide a detailed description of the infiltration technique. Design. A randomized, double-blind, placebo-controlled study following the CONSORT criteria. Setting. A university hospital. Patients. 48 patients undergoing posterior wall repair and perineorraphy. Methods. Patients received high-volume (26ml) ropivacaine 1% with epinephrine (n=23) or saline (n=22) infiltration using a systematic technique ensuring uniform delivery to all tissues incised, handled or instrumented during the procedure. Main outcome measures. Pain and opioid requirements were assessed for 24hours as well as time spent in the post-anesthesia care unit and time to first mobilization. Results. Pain at rest, during coughing and movement was significantly reduced for the first four hours with the high-volume local anesthetic infiltration technique (p<0.001-0.006). Opioid requirements and time spent in the post-anesthesia care unit were significantly reduced in the ropivacaine group (p<0.001 and p<0.001, respectively) as well as the time to first mobilization (p<0.014). Conclusion. Systematic high-volume infiltration analgesia is an effective analgesic technique in patients undergoing posterior wall repair and perineorraphy, and improves early recovery.

AB - Objective. To evaluate the analgesic effect of high-volume infiltration analgesia in urogenital prolapse surgery and provide a detailed description of the infiltration technique. Design. A randomized, double-blind, placebo-controlled study following the CONSORT criteria. Setting. A university hospital. Patients. 48 patients undergoing posterior wall repair and perineorraphy. Methods. Patients received high-volume (26ml) ropivacaine 1% with epinephrine (n=23) or saline (n=22) infiltration using a systematic technique ensuring uniform delivery to all tissues incised, handled or instrumented during the procedure. Main outcome measures. Pain and opioid requirements were assessed for 24hours as well as time spent in the post-anesthesia care unit and time to first mobilization. Results. Pain at rest, during coughing and movement was significantly reduced for the first four hours with the high-volume local anesthetic infiltration technique (p<0.001-0.006). Opioid requirements and time spent in the post-anesthesia care unit were significantly reduced in the ropivacaine group (p<0.001 and p<0.001, respectively) as well as the time to first mobilization (p<0.014). Conclusion. Systematic high-volume infiltration analgesia is an effective analgesic technique in patients undergoing posterior wall repair and perineorraphy, and improves early recovery.

U2 - 10.1111/j.1600-0412.2011.01234.x

DO - 10.1111/j.1600-0412.2011.01234.x

M3 - Journal article

SN - 0001-6349

VL - 90

SP - 1121

EP - 1125

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 10

ER -