Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study.

Peer Brehm Christensen; Henrik Bygum Krarup; Axel Møller; Alex Lund Laursen; Mette S Kjaer; Marianne Orholm; Jens Lindberg; Karin Groenbaek; Hans Kromann-Andersen; Nina Weis; NN NN; Nina Weis

doi:http://dx.doi.org/10.1080/00365540600978864

Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study.

Peer Brehm Christensen, Henrik Bygum Krarup, Axel Møller, Alex Lund Laursen, Mette S Kjaer, Marianne Orholm, Jens Lindberg, Karin Groenbaek, Hans Kromann-Andersen, Nina Weis, NN NN, Nina Weis

Department of Clinical Medicine

14 Citations (Scopus)

Abstract

We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis.
Udgivelsesdato: 2007-null

Original language	English
Journal	Scandinavian Journal of Infectious Diseases
Volume	39
Issue number	3
Pages (from-to)	245-9
Number of pages	4
ISSN	0036-5548
DOIs	https://doi.org/10.1080/00365540600978864
Publication status	Published - 2007

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Cite this

Christensen, P. B., Krarup, H. B., Møller, A., Laursen, A. L., Kjaer, M. S., Orholm, M., Lindberg, J., Groenbaek, K., Kromann-Andersen, H., Weis, N., NN, NN., & Weis, N. (2007). Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study. Scandinavian Journal of Infectious Diseases, 39(3), 245-9. https://doi.org/10.1080/00365540600978864

Christensen, PB, Krarup, HB, Møller, A, Laursen, AL, Kjaer, MS, Orholm, M, Lindberg, J, Groenbaek, K, Kromann-Andersen, H, Weis, N, NN, NN & Weis, N 2007, 'Liver biopsy performance and histological findings among patients with chronic viral hepatitis: a Danish database study.', Scandinavian Journal of Infectious Diseases, vol. 39, no. 3, pp. 245-9. https://doi.org/10.1080/00365540600978864

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abstract = "We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis. Udgivelsesdato: 2007-null",

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AU - Christensen, Peer Brehm

AU - Krarup, Henrik Bygum

AU - Møller, Axel

AU - Laursen, Alex Lund

AU - Kjaer, Mette S

AU - Orholm, Marianne

AU - Lindberg, Jens

AU - Groenbaek, Karin

AU - Kromann-Andersen, Hans

AU - Weis, Nina

AU - NN, NN

AU - Weis, Nina

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N2 - We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis. Udgivelsesdato: 2007-null

AB - We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis. Udgivelsesdato: 2007-null

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