Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study

Ulrik Schiøler Kesmodel; Mette Underbjerg; Tina Røndrup Kilburn; Leiv Bakketeig; Erik Lykke Mortensen; Nils Inge Landrø; Diana Schendel; Jacquelyn Bertrand; Jakob Grove; Shahul Ebrahim; Poul Thorsen

doi:10.1177/1403494809357093

Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study

Ulrik Schiøler Kesmodel, Mette Underbjerg, Tina Røndrup Kilburn, Leiv Bakketeig, Erik Lykke Mortensen, Nils Inge Landrø, Diana Schendel, Jacquelyn Bertrand, Jakob Grove, Shahul Ebrahim, Poul Thorsen

40 Citations (Scopus)

Abstract

Background: It has been suggested that even mild exposure to alcohol, caffeine, smoking, and poor diet may have adverse long-term neurodevelopmental effects. In addition, there is evidence that timing of high exposures (e.g. binge drinking) can have particularly negative effects. This paper describes the design and implementation of The Lifestyle During Pregnancy Study addressing major methodological challenges for studies in this field. The study examines the effects of lifestyle during pregnancy on offspring neurodevelopment. Methods: In 2003, we initiated a prospective follow-up of 1750 mother—child pairs, sampled on the basis of maternal alcohol drinking patterns from The Danish National Birth Cohort (DNBC), a study of 101,042 pregnancies enrolled 1997—2003. Data collection in the DNBC involved four prenatal and postnatal maternal interviews, providing detailed information on maternal alcohol drinking patterns before and during pregnancy, caffeine intake, smoking, diet, and other lifestyle, medical, and sociodemographic factors. Results: At the age of 5 years, the children and their mothers participated in a comprehensive assessment of neurobehavioural development focusing on global cognition, specific cognitive functions, and behaviour. Two new tests assessing attention and speed of information processing among children were developed, and data on important potential confounders such as maternal intelligence quotient, vision, and hearing abilities were collected. Efforts were made to standardise procedures and obtain high inter-rater reliability. Conclusions: We expect that the study will illuminate the significance or lack of significance of maternal lifestyle during pregnancy and contribute to better understanding the effects of alcohol drinking during pregnancy at low to moderate consumption levels.

Original language	English
Journal	Scandinavian Journal of Public Health
Volume	38
Issue number	2
Pages (from-to)	208-19
Number of pages	11
ISSN	1403-4948
DOIs	https://doi.org/10.1177/1403494809357093
Publication status	Published - Mar 2010

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Kesmodel, U. S., Underbjerg, M., Kilburn, T. R., Bakketeig, L., Mortensen, E. L., Landrø, N. I., Schendel, D., Bertrand, J., Grove, J., Ebrahim, S., & Thorsen, P. (2010). Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study. Scandinavian Journal of Public Health, 38(2), 208-19. https://doi.org/10.1177/1403494809357093

Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study. / Kesmodel, Ulrik Schiøler; Underbjerg, Mette; Kilburn, Tina Røndrup et al.

In: Scandinavian Journal of Public Health, Vol. 38, No. 2, 03.2010, p. 208-19.

Research output: Contribution to journal › Journal article › Research › peer-review

Kesmodel, US, Underbjerg, M, Kilburn, TR, Bakketeig, L, Mortensen, EL, Landrø, NI, Schendel, D, Bertrand, J, Grove, J, Ebrahim, S & Thorsen, P 2010, 'Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study', Scandinavian Journal of Public Health, vol. 38, no. 2, pp. 208-19. https://doi.org/10.1177/1403494809357093

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title = "Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study",

abstract = "Background: It has been suggested that even mild exposure to alcohol, caffeine, smoking, and poor diet may have adverse long-term neurodevelopmental effects. In addition, there is evidence that timing of high exposures (e.g. binge drinking) can have particularly negative effects. This paper describes the design and implementation of The Lifestyle During Pregnancy Study addressing major methodological challenges for studies in this field. The study examines the effects of lifestyle during pregnancy on offspring neurodevelopment. Methods: In 2003, we initiated a prospective follow-up of 1750 mother—child pairs, sampled on the basis of maternal alcohol drinking patterns from The Danish National Birth Cohort (DNBC), a study of 101,042 pregnancies enrolled 1997—2003. Data collection in the DNBC involved four prenatal and postnatal maternal interviews, providing detailed information on maternal alcohol drinking patterns before and during pregnancy, caffeine intake, smoking, diet, and other lifestyle, medical, and sociodemographic factors. Results: At the age of 5 years, the children and their mothers participated in a comprehensive assessment of neurobehavioural development focusing on global cognition, specific cognitive functions, and behaviour. Two new tests assessing attention and speed of information processing among children were developed, and data on important potential confounders such as maternal intelligence quotient, vision, and hearing abilities were collected. Efforts were made to standardise procedures and obtain high inter-rater reliability. Conclusions: We expect that the study will illuminate the significance or lack of significance of maternal lifestyle during pregnancy and contribute to better understanding the effects of alcohol drinking during pregnancy at low to moderate consumption levels.",

author = "Kesmodel, {Ulrik Schi{\o}ler} and Mette Underbjerg and Kilburn, {Tina R{\o}ndrup} and Leiv Bakketeig and Mortensen, {Erik Lykke} and Landr{\o}, {Nils Inge} and Diana Schendel and Jacquelyn Bertrand and Jakob Grove and Shahul Ebrahim and Poul Thorsen",

note = "Keywords: Alcohol Drinking; Child Behavior Disorders; Child Development; Child, Preschool; Cognition Disorders; Cohort Studies; Female; Follow-Up Studies; Food Habits; Humans; Intelligence; Life Style; Maternal Exposure; Pregnancy; Psychomotor Performance; Questionnaires; Smoking",

year = "2010",

month = mar,

doi = "10.1177/1403494809357093",

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pages = "208--19",

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T1 - Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study

AU - Kesmodel, Ulrik Schiøler

AU - Underbjerg, Mette

AU - Kilburn, Tina Røndrup

AU - Bakketeig, Leiv

AU - Mortensen, Erik Lykke

AU - Landrø, Nils Inge

AU - Schendel, Diana

AU - Bertrand, Jacquelyn

AU - Grove, Jakob

AU - Ebrahim, Shahul

AU - Thorsen, Poul

N1 - Keywords: Alcohol Drinking; Child Behavior Disorders; Child Development; Child, Preschool; Cognition Disorders; Cohort Studies; Female; Follow-Up Studies; Food Habits; Humans; Intelligence; Life Style; Maternal Exposure; Pregnancy; Psychomotor Performance; Questionnaires; Smoking

PY - 2010/3

Y1 - 2010/3

N2 - Background: It has been suggested that even mild exposure to alcohol, caffeine, smoking, and poor diet may have adverse long-term neurodevelopmental effects. In addition, there is evidence that timing of high exposures (e.g. binge drinking) can have particularly negative effects. This paper describes the design and implementation of The Lifestyle During Pregnancy Study addressing major methodological challenges for studies in this field. The study examines the effects of lifestyle during pregnancy on offspring neurodevelopment. Methods: In 2003, we initiated a prospective follow-up of 1750 mother—child pairs, sampled on the basis of maternal alcohol drinking patterns from The Danish National Birth Cohort (DNBC), a study of 101,042 pregnancies enrolled 1997—2003. Data collection in the DNBC involved four prenatal and postnatal maternal interviews, providing detailed information on maternal alcohol drinking patterns before and during pregnancy, caffeine intake, smoking, diet, and other lifestyle, medical, and sociodemographic factors. Results: At the age of 5 years, the children and their mothers participated in a comprehensive assessment of neurobehavioural development focusing on global cognition, specific cognitive functions, and behaviour. Two new tests assessing attention and speed of information processing among children were developed, and data on important potential confounders such as maternal intelligence quotient, vision, and hearing abilities were collected. Efforts were made to standardise procedures and obtain high inter-rater reliability. Conclusions: We expect that the study will illuminate the significance or lack of significance of maternal lifestyle during pregnancy and contribute to better understanding the effects of alcohol drinking during pregnancy at low to moderate consumption levels.

AB - Background: It has been suggested that even mild exposure to alcohol, caffeine, smoking, and poor diet may have adverse long-term neurodevelopmental effects. In addition, there is evidence that timing of high exposures (e.g. binge drinking) can have particularly negative effects. This paper describes the design and implementation of The Lifestyle During Pregnancy Study addressing major methodological challenges for studies in this field. The study examines the effects of lifestyle during pregnancy on offspring neurodevelopment. Methods: In 2003, we initiated a prospective follow-up of 1750 mother—child pairs, sampled on the basis of maternal alcohol drinking patterns from The Danish National Birth Cohort (DNBC), a study of 101,042 pregnancies enrolled 1997—2003. Data collection in the DNBC involved four prenatal and postnatal maternal interviews, providing detailed information on maternal alcohol drinking patterns before and during pregnancy, caffeine intake, smoking, diet, and other lifestyle, medical, and sociodemographic factors. Results: At the age of 5 years, the children and their mothers participated in a comprehensive assessment of neurobehavioural development focusing on global cognition, specific cognitive functions, and behaviour. Two new tests assessing attention and speed of information processing among children were developed, and data on important potential confounders such as maternal intelligence quotient, vision, and hearing abilities were collected. Efforts were made to standardise procedures and obtain high inter-rater reliability. Conclusions: We expect that the study will illuminate the significance or lack of significance of maternal lifestyle during pregnancy and contribute to better understanding the effects of alcohol drinking during pregnancy at low to moderate consumption levels.

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DO - 10.1177/1403494809357093

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SN - 1403-4948

VL - 38

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JO - Acta socio-medica Scandinavica

JF - Acta socio-medica Scandinavica

IS - 2

ER -

Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study

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