Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

J. Ahnstrom; O. Axler; M. Jauhiainen; V. Salomaa; A.S. Havulinna; C. Ehnholm; R. Frikke-Schmidt; A. Tybjaerg-Hansen; B. Dahlback

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

J. Ahnstrom, O. Axler, M. Jauhiainen, V. Salomaa, A.S. Havulinna, C. Ehnholm, R. Frikke-Schmidt, A. Tybjaerg-Hansen, B. Dahlback

49 Citations (Scopus)

Abstract

Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study
Udgivelsesdato: 2008/9

Original language	English
Journal	Journal of Lipid Research
Volume	49
Issue number	9
Pages (from-to)	1912-1917
Number of pages	5
ISSN	0022-2275
Publication status	Published - 2008

Cite this

@article{b1990c60f37a11ddbf70000ea68e967b,

title = "Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies",

abstract = "Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study Udgivelsesdato: 2008/9",

author = "J. Ahnstrom and O. Axler and M. Jauhiainen and V. Salomaa and A.S. Havulinna and C. Ehnholm and R. Frikke-Schmidt and A. Tybjaerg-Hansen and B. Dahlback",

year = "2008",

language = "English",

volume = "49",

pages = "1912--1917",

journal = "Journal of Lipid Research",

issn = "0022-2275",

publisher = "American Society for Biochemistry and Molecular Biology, Inc.",

number = "9",

}

TY - JOUR

T1 - Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

AU - Ahnstrom, J.

AU - Axler, O.

AU - Jauhiainen, M.

AU - Salomaa, V.

AU - Havulinna, A.S.

AU - Ehnholm, C.

AU - Frikke-Schmidt, R.

AU - Tybjaerg-Hansen, A.

AU - Dahlback, B.

PY - 2008

Y1 - 2008

N2 - Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study Udgivelsesdato: 2008/9

AB - Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study Udgivelsesdato: 2008/9

M3 - Journal article

SN - 0022-2275

VL - 49

SP - 1912

EP - 1917

JO - Journal of Lipid Research

JF - Journal of Lipid Research

IS - 9

ER -