TY - JOUR
T1 - LC-QTOF/MS metabolomic profiles in human plasma after a 5-week high dietary fiber intake
AU - Johansson-Persson, Anna
AU - Barri, Thaer
AU - Ulmius, Matilda
AU - Onning, Gunilla
AU - Dragsted, Lars Ove
N1 - CURIS 2013 NEXS 077
PY - 2013/5
Y1 - 2013/5
N2 - The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n¿=¿25) aged 58.6 (1.1)¿years (mean and SD) with a body mass index of 26.6 (0.5)¿kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p¿
AB - The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n¿=¿25) aged 58.6 (1.1)¿years (mean and SD) with a body mass index of 26.6 (0.5)¿kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p¿
U2 - 10.1007/s00216-013-6874-5
DO - 10.1007/s00216-013-6874-5
M3 - Journal article
C2 - 23535740
SN - 1618-2642
VL - 405
SP - 4799
EP - 4809
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
IS - 14
ER -