Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life

Mette Olaf Nielsen; Anna Hauntoft Kongsted; M.P. Thygesen; Anders Bjerring Strathe; S. Caddy; Bjørn Quistorff; Wenche Jørgensen; Vibeke Grøsfjeld Christensen; Sanne Vinter Husted; André Chwalibog; Kristen Sejrsen; Stig Purup; Eiliv Lars Svalastoga; Fintan McEvoy; Lærke Johnsen

doi:10.1017/S0007114512004199

Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life

Mette Olaf Nielsen, Anna Hauntoft Kongsted, M.P. Thygesen, Anders Bjerring Strathe, S. Caddy, Bjørn Quistorff, Wenche Jørgensen, Vibeke Grøsfjeld Christensen, Sanne Vinter Husted, André Chwalibog, Kristen Sejrsen, Stig Purup, Eiliv Lars Svalastoga, Fintan McEvoy, Lærke Johnsen

Inflammation, Metabolism and Oxidation

29 Citations (Scopus)

Abstract

We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50 % of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventional (CONV) diet and the other a high-carbohydrate-high-fat (HCHF) diet, resulting in four groups of offspring: NORM-CONV; NORM-HCHF; LOW-CONV; LOW-HCHF. At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestation reduced the birth weight of LOW offspring (P< 0·05), and its long-term effects were increased adrenal size in male lambs and adult females (P< 0·05), increased neonatal appetite for fat-(P= 0·004) rather than carbohydrate-rich feeds (P< 0·001) and reduced deposition of subcutaneous fat in both sexes (P< 0·05). Furthermore, LOW-HCHF female lambs had markedly higher visceral:subcutaneous fat ratios compared with the other groups (P< 0·001). Postnatal overfeeding (HCHF) resulted in obesity (>30 % fat in soft tissue) and widespread ectopic lipid deposition. In conclusion, our sheep model revealed strong pre- and postnatal impacts on growth, food preferences and fat deposition patterns. The present findings support a role for subcutaneous adipose tissue in the development of visceral adiposity, which in humans is known to precede the development of the metabolic syndrome in human adults.

Original language	English
Journal	British Journal of Nutrition
Volume	109
Issue number	11
Pages (from-to)	2098-2110
Number of pages	13
ISSN	0007-1145
DOIs	https://doi.org/10.1017/S0007114512004199
Publication status	Published - Jun 2013

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10.1017/S0007114512004199

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Nielsen, M. O., Kongsted, A. H., Thygesen, M. P., Strathe, A. B., Caddy, S., Quistorff, B., Jørgensen, W., Christensen, V. G., Husted, S. V., Chwalibog, A., Sejrsen, K., Purup, S., Svalastoga, E. L., McEvoy, F., & Johnsen, L. (2013). Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life. British Journal of Nutrition, 109(11), 2098-2110. https://doi.org/10.1017/S0007114512004199

Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life. / Nielsen, Mette Olaf; Kongsted, Anna Hauntoft; Thygesen, M.P. et al.
In: British Journal of Nutrition, Vol. 109, No. 11, 06.2013, p. 2098-2110.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, MO, Kongsted, AH, Thygesen, MP, Strathe, AB, Caddy, S, Quistorff, B, Jørgensen, W, Christensen, VG, Husted, SV , Chwalibog, A, Sejrsen, K, Purup, S, Svalastoga, EL , McEvoy, F & Johnsen, L 2013, 'Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life', British Journal of Nutrition, vol. 109, no. 11, pp. 2098-2110. https://doi.org/10.1017/S0007114512004199

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title = "Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life",

abstract = "We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50 % of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventional (CONV) diet and the other a high-carbohydrate-high-fat (HCHF) diet, resulting in four groups of offspring: NORM-CONV; NORM-HCHF; LOW-CONV; LOW-HCHF. At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestation reduced the birth weight of LOW offspring (P< 0·05), and its long-term effects were increased adrenal size in male lambs and adult females (P< 0·05), increased neonatal appetite for fat-(P= 0·004) rather than carbohydrate-rich feeds (P< 0·001) and reduced deposition of subcutaneous fat in both sexes (P< 0·05). Furthermore, LOW-HCHF female lambs had markedly higher visceral:subcutaneous fat ratios compared with the other groups (P< 0·001). Postnatal overfeeding (HCHF) resulted in obesity (>30 % fat in soft tissue) and widespread ectopic lipid deposition. In conclusion, our sheep model revealed strong pre- and postnatal impacts on growth, food preferences and fat deposition patterns. The present findings support a role for subcutaneous adipose tissue in the development of visceral adiposity, which in humans is known to precede the development of the metabolic syndrome in human adults.",

author = "Nielsen, {Mette Olaf} and Kongsted, {Anna Hauntoft} and M.P. Thygesen and Strathe, {Anders Bjerring} and S. Caddy and Bj{\o}rn Quistorff and Wenche J{\o}rgensen and Christensen, {Vibeke Gr{\o}sfjeld} and Husted, {Sanne Vinter} and Andr{\'e} Chwalibog and Kristen Sejrsen and Stig Purup and Svalastoga, {Eiliv Lars} and Fintan McEvoy and L{\ae}rke Johnsen",

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T1 - Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life

AU - Nielsen, Mette Olaf

AU - Kongsted, Anna Hauntoft

AU - Thygesen, M.P.

AU - Strathe, Anders Bjerring

AU - Caddy, S.

AU - Quistorff, Bjørn

AU - Jørgensen, Wenche

AU - Christensen, Vibeke Grøsfjeld

AU - Husted, Sanne Vinter

AU - Chwalibog, André

AU - Sejrsen, Kristen

AU - Purup, Stig

AU - Svalastoga, Eiliv Lars

AU - McEvoy, Fintan

AU - Johnsen, Lærke

PY - 2013/6

Y1 - 2013/6

N2 - We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50 % of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventional (CONV) diet and the other a high-carbohydrate-high-fat (HCHF) diet, resulting in four groups of offspring: NORM-CONV; NORM-HCHF; LOW-CONV; LOW-HCHF. At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestation reduced the birth weight of LOW offspring (P< 0·05), and its long-term effects were increased adrenal size in male lambs and adult females (P< 0·05), increased neonatal appetite for fat-(P= 0·004) rather than carbohydrate-rich feeds (P< 0·001) and reduced deposition of subcutaneous fat in both sexes (P< 0·05). Furthermore, LOW-HCHF female lambs had markedly higher visceral:subcutaneous fat ratios compared with the other groups (P< 0·001). Postnatal overfeeding (HCHF) resulted in obesity (>30 % fat in soft tissue) and widespread ectopic lipid deposition. In conclusion, our sheep model revealed strong pre- and postnatal impacts on growth, food preferences and fat deposition patterns. The present findings support a role for subcutaneous adipose tissue in the development of visceral adiposity, which in humans is known to precede the development of the metabolic syndrome in human adults.

AB - We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50 % of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventional (CONV) diet and the other a high-carbohydrate-high-fat (HCHF) diet, resulting in four groups of offspring: NORM-CONV; NORM-HCHF; LOW-CONV; LOW-HCHF. At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestation reduced the birth weight of LOW offspring (P< 0·05), and its long-term effects were increased adrenal size in male lambs and adult females (P< 0·05), increased neonatal appetite for fat-(P= 0·004) rather than carbohydrate-rich feeds (P< 0·001) and reduced deposition of subcutaneous fat in both sexes (P< 0·05). Furthermore, LOW-HCHF female lambs had markedly higher visceral:subcutaneous fat ratios compared with the other groups (P< 0·001). Postnatal overfeeding (HCHF) resulted in obesity (>30 % fat in soft tissue) and widespread ectopic lipid deposition. In conclusion, our sheep model revealed strong pre- and postnatal impacts on growth, food preferences and fat deposition patterns. The present findings support a role for subcutaneous adipose tissue in the development of visceral adiposity, which in humans is known to precede the development of the metabolic syndrome in human adults.

U2 - 10.1017/S0007114512004199

DO - 10.1017/S0007114512004199

M3 - Journal article

C2 - 23069212

SN - 0007-1145

VL - 109

SP - 2098

EP - 2110

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 11

ER -

Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life

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