Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Kyriaki Michailidou; Per Hall; Anna Gonzalez-Neira; Maya Ghoussaini; Joe Dennis; Roger L Milne; Marjanka K Schmidt; Jenny Chang-Claude; Stig E Bojesen; Manjeet K Bolla; Qin Wang; Ed Dicks; Andrew Roger Lee; Clare Turnbull; Nazneen Rahman; Olivia Fletcher; Julian Peto; Lorna Gibson; Isabel Dos Santos Silva; Heli Nevanlinna; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Kamila Czene; Astrid Irwanto; Jianjun Liu; Quinten Waisfisz; Hanne Meijers-Heijboer; Muriel Adank; Rob B van der Luijt; Rebecca Hein; Norbert Dahmen; Lars Beckman; Alfons Meindl; Rita K Schmutzler; Bertram Müller-Myhsok; Peter Lichtner; John L Hopper; Melissa C Southey; Enes Makalic; Daniel F Schmidt; Andre G Uitterlinden; Albert Hofman; David J Hunter; Stephen J Chanock; Daniel Vincent; François Bacot; Daniel C Tessier; Sander Canisius; Børge G Nordestgaard; Breast and Ovarian Cancer Susceptibility Collaboration

doi:10.1038/ng.2563

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Kyriaki Michailidou, Per Hall, Anna Gonzalez-Neira, Maya Ghoussaini, Joe Dennis, Roger L Milne, Marjanka K Schmidt, Jenny Chang-Claude, Stig E Bojesen, Manjeet K Bolla, Qin Wang, Ed Dicks, Andrew Roger Lee, Clare Turnbull, Nazneen Rahman, Olivia Fletcher, Julian Peto, Lorna Gibson, Isabel Dos Santos Silva, Heli NevanlinnaTaru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Kamila Czene, Astrid Irwanto, Jianjun Liu, Quinten Waisfisz, Hanne Meijers-Heijboer, Muriel Adank, Rob B van der Luijt, Rebecca Hein, Norbert Dahmen, Lars Beckman, Alfons Meindl, Rita K Schmutzler, Bertram Müller-Myhsok, Peter Lichtner, John L Hopper, Melissa C Southey, Enes Makalic, Daniel F Schmidt, Andre G Uitterlinden, Albert Hofman, David J Hunter, Stephen J Chanock, Daniel Vincent, François Bacot, Daniel C Tessier, Sander Canisius, Børge G Nordestgaard, Breast and Ovarian Cancer Susceptibility Collaboration

747 Citations (Scopus)

Abstract

Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.

Original language	English
Journal	Nature Genetics
Volume	45
Issue number	4
Pages (from-to)	353-61, 361e1-2
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.2563
Publication status	Published - Apr 2013

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Michailidou, K., Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R. L., Schmidt, M. K., Chang-Claude, J., Bojesen, S. E., Bolla, M. K., Wang, Q., Dicks, E., Lee, A. R., Turnbull, C., Rahman, N., Fletcher, O., Peto, J., Gibson, L., Dos Santos Silva, I., ... Breast and Ovarian Cancer Susceptibility Collaboration (2013). Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics, 45(4), 353-61, 361e1-2. https://doi.org/10.1038/ng.2563

Michailidou, K, Hall, P, Gonzalez-Neira, A, Ghoussaini, M, Dennis, J, Milne, RL, Schmidt, MK, Chang-Claude, J, Bojesen, SE, Bolla, MK, Wang, Q, Dicks, E, Lee, AR, Turnbull, C, Rahman, N, Fletcher, O, Peto, J, Gibson, L, Dos Santos Silva, I, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Czene, K, Irwanto, A, Liu, J, Waisfisz, Q, Meijers-Heijboer, H, Adank, M, van der Luijt, RB, Hein, R, Dahmen, N, Beckman, L, Meindl, A, Schmutzler, RK, Müller-Myhsok, B, Lichtner, P, Hopper, JL, Southey, MC, Makalic, E, Schmidt, DF, Uitterlinden, AG, Hofman, A, Hunter, DJ, Chanock, SJ, Vincent, D, Bacot, F, Tessier, DC, Canisius, S, Nordestgaard, BG & Breast and Ovarian Cancer Susceptibility Collaboration 2013, 'Large-scale genotyping identifies 41 new loci associated with breast cancer risk', Nature Genetics, vol. 45, no. 4, pp. 353-61, 361e1-2. https://doi.org/10.1038/ng.2563

@article{362198dc30fa451880a1e97de1ebcc83,

title = "Large-scale genotyping identifies 41 new loci associated with breast cancer risk",

abstract = "Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.",

author = "Kyriaki Michailidou and Per Hall and Anna Gonzalez-Neira and Maya Ghoussaini and Joe Dennis and Milne, {Roger L} and Schmidt, {Marjanka K} and Jenny Chang-Claude and Bojesen, {Stig E} and Bolla, {Manjeet K} and Qin Wang and Ed Dicks and Lee, {Andrew Roger} and Clare Turnbull and Nazneen Rahman and Olivia Fletcher and Julian Peto and Lorna Gibson and {Dos Santos Silva}, Isabel and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Kamila Czene and Astrid Irwanto and Jianjun Liu and Quinten Waisfisz and Hanne Meijers-Heijboer and Muriel Adank and {van der Luijt}, {Rob B} and Rebecca Hein and Norbert Dahmen and Lars Beckman and Alfons Meindl and Schmutzler, {Rita K} and Bertram M{\"u}ller-Myhsok and Peter Lichtner and Hopper, {John L} and Southey, {Melissa C} and Enes Makalic and Schmidt, {Daniel F} and Uitterlinden, {Andre G} and Albert Hofman and Hunter, {David J} and Chanock, {Stephen J} and Daniel Vincent and Fran{\c c}ois Bacot and Tessier, {Daniel C} and Sander Canisius and Nordestgaard, {B{\o}rge G} and B{\o}rge Nordestgaard",

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month = apr,

doi = "10.1038/ng.2563",

language = "English",

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T1 - Large-scale genotyping identifies 41 new loci associated with breast cancer risk

AU - Michailidou, Kyriaki

AU - Hall, Per

AU - Gonzalez-Neira, Anna

AU - Ghoussaini, Maya

AU - Dennis, Joe

AU - Milne, Roger L

AU - Schmidt, Marjanka K

AU - Chang-Claude, Jenny

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Dicks, Ed

AU - Lee, Andrew Roger

AU - Turnbull, Clare

AU - Rahman, Nazneen

AU - Fletcher, Olivia

AU - Peto, Julian

AU - Gibson, Lorna

AU - Dos Santos Silva, Isabel

AU - Nevanlinna, Heli

AU - Muranen, Taru A

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Czene, Kamila

AU - Irwanto, Astrid

AU - Liu, Jianjun

AU - Waisfisz, Quinten

AU - Meijers-Heijboer, Hanne

AU - Adank, Muriel

AU - van der Luijt, Rob B

AU - Hein, Rebecca

AU - Dahmen, Norbert

AU - Beckman, Lars

AU - Meindl, Alfons

AU - Schmutzler, Rita K

AU - Müller-Myhsok, Bertram

AU - Lichtner, Peter

AU - Hopper, John L

AU - Southey, Melissa C

AU - Makalic, Enes

AU - Schmidt, Daniel F

AU - Uitterlinden, Andre G

AU - Hofman, Albert

AU - Hunter, David J

AU - Chanock, Stephen J

AU - Vincent, Daniel

AU - Bacot, François

AU - Tessier, Daniel C

AU - Canisius, Sander

AU - Nordestgaard, Børge G

AU - Breast and Ovarian Cancer Susceptibility Collaboration

PY - 2013/4

Y1 - 2013/4

N2 - Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.

AB - Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.

U2 - 10.1038/ng.2563

DO - 10.1038/ng.2563

M3 - Journal article

C2 - 23535729

SN - 1061-4036

VL - 45

SP - 353-61, 361e1-2

JO - Nature: New biology

JF - Nature: New biology

IS - 4

ER -

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Abstract

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