TY - JOUR
T1 - Laparoscopic and robotic nephroureterectomy
T2 - does lymphadenectomy have an impact on the clinical outcome?
AU - Azawi, Nessn H
AU - Berg, Kasper Drimer
AU - Thamsborg, Andreas Key Milan
AU - Dahl, Claus
AU - Jepsen, Jan Viberg
AU - Kroman-Andersen, Bjarne
AU - Poulsen, Johan
AU - Petersen, Helle Handler
AU - Henning Olsen, L
AU - Jensen, Jørgen Bjerggaard
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Purpose: To evaluate the effect of lymphadenectomy (LND) in conjunction with nephroureterectomy on cancer-specific mortality (CSM) and overall survival (OS) for patients with muscle-invasive UTUC. Methods: A retrospective, multicenter study of patients with UTUC, clinical stage N0M0, who underwent nephroureterectomy between January 2008 and December 2014 was conducted. Outcome measures were OS and CSM. Results: In total, 298 patients underwent robot-assisted or laparoscopic radical nephroureterectomy with a final histological diagnosis of UTUC. LND was performed in 46 (15.4%). One hundred and seventy-two patients (62%) had non-muscle-invasive disease (NMID); 105 patients (38%) had muscle-invasive disease (MID). Median time of follow-up was 43.5 months (95% CI 36.0–47.2). For patients with MID, the 5-year cumulative incidence of all-cause mortality and CSM was 73.5% (95% CI 60.4–86.6) and 52.4% (95% CI 38.9–65.9), respectively (p < 0.0001). There was no significant difference in OS between patients with N1 and patients with N0 disease (p = 0.53). The 5-year OS rates were 30.5% (95% CI 6.6–54.4) and 25.7% (95% CI 10.9–40.5), respectively. This study is limited by its retrospective nature. There may also have been bias in the selection of patients undergoing LND. Conclusions: Five-year OS and CSM are comparable between patients with N1 and N0 MID. This evidence may support the use of the LND procedure in patients with muscle-invasive UTUC.
AB - Purpose: To evaluate the effect of lymphadenectomy (LND) in conjunction with nephroureterectomy on cancer-specific mortality (CSM) and overall survival (OS) for patients with muscle-invasive UTUC. Methods: A retrospective, multicenter study of patients with UTUC, clinical stage N0M0, who underwent nephroureterectomy between January 2008 and December 2014 was conducted. Outcome measures were OS and CSM. Results: In total, 298 patients underwent robot-assisted or laparoscopic radical nephroureterectomy with a final histological diagnosis of UTUC. LND was performed in 46 (15.4%). One hundred and seventy-two patients (62%) had non-muscle-invasive disease (NMID); 105 patients (38%) had muscle-invasive disease (MID). Median time of follow-up was 43.5 months (95% CI 36.0–47.2). For patients with MID, the 5-year cumulative incidence of all-cause mortality and CSM was 73.5% (95% CI 60.4–86.6) and 52.4% (95% CI 38.9–65.9), respectively (p < 0.0001). There was no significant difference in OS between patients with N1 and patients with N0 disease (p = 0.53). The 5-year OS rates were 30.5% (95% CI 6.6–54.4) and 25.7% (95% CI 10.9–40.5), respectively. This study is limited by its retrospective nature. There may also have been bias in the selection of patients undergoing LND. Conclusions: Five-year OS and CSM are comparable between patients with N1 and N0 MID. This evidence may support the use of the LND procedure in patients with muscle-invasive UTUC.
U2 - 10.1007/s11255-017-1672-1
DO - 10.1007/s11255-017-1672-1
M3 - Journal article
C2 - 28762118
SN - 0301-1623
VL - 49
SP - 1785
EP - 1792
JO - International Urology and Nephrology
JF - International Urology and Nephrology
IS - 10
ER -
