Lack of immunomodulating effect of disulfiram on HIV positive patients

M Hørding; P C Gøtzsche; Ib Christian Bygbjerg; L D Christensen; V Faber

Lack of immunomodulating effect of disulfiram on HIV positive patients

M Hørding, P C Gøtzsche, Ib Christian Bygbjerg, L D Christensen, V Faber

Department of Immunology and Microbiology

1 Citation (Scopus)

Abstract

Disulfiram (Antabuse (R)) is metabolized to two molecules of diethyldithiocarbamate, which has been reported to be an immunomodulating agent. In a double blind trial, 15 HIV antibody positive homosexual men were given daily doses of 100 mg or 400 mg of disulfiram or placebo, for 4 weeks. All had a CD4-count below 500 X 10(6)/l and/or a pokeweed mitogen response in a lymphocyte proliferation assay less than 50% of normal controls. None suffered from opportunistic infections. No significant effect of disulfiram on immunological, haematological, biochemical or clinical variables was observed in this short-term trial.

Original language	English
Journal	International Journal of Immunopharmacology
Volume	12
Issue number	2
Pages (from-to)	145-7
Number of pages	3
ISSN	0192-0561
Publication status	Published - 1 Jan 1990

Keywords

Adjuvants, Immunologic
Disulfiram
HIV Seropositivity
Humans
Male
Randomized Controlled Trials as Topic
Time Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{bcd2823061d34d0a86b2d4cd907d3d4d,

title = "Lack of immunomodulating effect of disulfiram on HIV positive patients",

abstract = "Disulfiram (Antabuse (R)) is metabolized to two molecules of diethyldithiocarbamate, which has been reported to be an immunomodulating agent. In a double blind trial, 15 HIV antibody positive homosexual men were given daily doses of 100 mg or 400 mg of disulfiram or placebo, for 4 weeks. All had a CD4-count below 500 X 10(6)/l and/or a pokeweed mitogen response in a lymphocyte proliferation assay less than 50% of normal controls. None suffered from opportunistic infections. No significant effect of disulfiram on immunological, haematological, biochemical or clinical variables was observed in this short-term trial.",

keywords = "Adjuvants, Immunologic, Disulfiram, HIV Seropositivity, Humans, Male, Randomized Controlled Trials as Topic, Time Factors",

author = "M H{\o}rding and G{\o}tzsche, {P C} and Bygbjerg, {Ib Christian} and Christensen, {L D} and V Faber",

year = "1990",

month = jan,

day = "1",

language = "English",

volume = "12",

pages = "145--7",

journal = "International Journal of Immunopharmacology",

issn = "0192-0561",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Lack of immunomodulating effect of disulfiram on HIV positive patients

AU - Hørding, M

AU - Gøtzsche, P C

AU - Bygbjerg, Ib Christian

AU - Christensen, L D

AU - Faber, V

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Disulfiram (Antabuse (R)) is metabolized to two molecules of diethyldithiocarbamate, which has been reported to be an immunomodulating agent. In a double blind trial, 15 HIV antibody positive homosexual men were given daily doses of 100 mg or 400 mg of disulfiram or placebo, for 4 weeks. All had a CD4-count below 500 X 10(6)/l and/or a pokeweed mitogen response in a lymphocyte proliferation assay less than 50% of normal controls. None suffered from opportunistic infections. No significant effect of disulfiram on immunological, haematological, biochemical or clinical variables was observed in this short-term trial.

AB - Disulfiram (Antabuse (R)) is metabolized to two molecules of diethyldithiocarbamate, which has been reported to be an immunomodulating agent. In a double blind trial, 15 HIV antibody positive homosexual men were given daily doses of 100 mg or 400 mg of disulfiram or placebo, for 4 weeks. All had a CD4-count below 500 X 10(6)/l and/or a pokeweed mitogen response in a lymphocyte proliferation assay less than 50% of normal controls. None suffered from opportunistic infections. No significant effect of disulfiram on immunological, haematological, biochemical or clinical variables was observed in this short-term trial.

KW - Adjuvants, Immunologic

KW - Disulfiram

KW - HIV Seropositivity

KW - Humans

KW - Male

KW - Randomized Controlled Trials as Topic

KW - Time Factors

M3 - Journal article

C2 - 2184133

SN - 0192-0561

VL - 12

SP - 145

EP - 147

JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

IS - 2

ER -

Lack of immunomodulating effect of disulfiram on HIV positive patients

Abstract

Keywords

UN SDGs

Fingerprint

Cite this