Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding

TY - JOUR

T1 - Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding

AU - Madsen, K

AU - Hasselbalch, Bo Jacob

AU - Frederiksen, K S

AU - Haahr, M E

AU - Gade, Anders

AU - Law, Ian

AU - Price, J C

AU - Knudsen, Gitte Moos

AU - Kessing, Lars Vedel

AU - Hasselbalch, Steen

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012/10

Y1 - 2012/10

N2 - Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-β (Aβ) levels using [11C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [11C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [11C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [11C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.

AB - Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-β (Aβ) levels using [11C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [11C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [11C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [11C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.

U2 - 10.1016/j.neurobiolaging.2011.11.021

DO - 10.1016/j.neurobiolaging.2011.11.021

M3 - Journal article

C2 - 22192243

SN - 0197-4580

VL - 33

SP - 2334

EP - 2342

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 12

ER -