Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

J L Zhu; Lisbeth E. Knudsen; Anne-Marie Nybo Andersen; N H Hjollund; Jørn Olsen

doi:10.1136/oem.2005.021204

Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

J L Zhu, Lisbeth E. Knudsen, Anne-Marie Nybo Andersen, N H Hjollund, Jørn Olsen

31 Citations (Scopus)

Abstract

AIMS: To examine pregnancy outcomes in women doing laboratory work. METHODS: Using data from the Danish National Birth Cohort (1997-2003), the authors conducted a prospective cohort study of 1025 female laboratory technicians and 8037 female teachers (as reference). The laboratory technicians were asked about laboratory work tasks during pregnancy in an interview (at around 16 weeks of gestation). Pregnancy outcomes were obtained by linking the cohort to the national registers. Hazard ratios (HRs) of late fetal loss and diagnosing of congenital malformations were calculated by using Cox regression, and odds ratios (ORs) of preterm birth and small for gestational age were calculated by using logistic regression. RESULTS: Overall, there were no significant differences in pregnancy outcomes between laboratory technicians and teachers. However, we found that laboratory technicians working with radioimmunoassay or radiolabelling had an increased risk of preterm birth (OR = 2.2, 95% CI 0.8 to 6.2 for radioimmunoassay, and OR = 1.9, 95% CI 0.8 to 4.6 for radiolabelling) and "major" malformations (HR = 2.1, 95% CI 1.0 to 4.7 for radioimmunoassay, and HR = 1.8, 95% CI 0.9 to 3.7 for radiolabelling). The ORs of preterm birth doubled for women working with these tasks every day or several times a week. When an exposure matrix was applied, an increased risk of "major" malformations for exposure to organic solvents was seen. CONCLUSIONS: The results did not indicate any high risk of reproductive failures in laboratory technicians in general. Exposure to radioisotopes may carry a high risk of preterm birth and congenital malformations. This finding deserves further investigation.

Original language	English
Journal	Occupational and Environmental Medicine
Volume	63
Issue number	1
Pages (from-to)	53-8
Number of pages	5
ISSN	1351-0711
DOIs	https://doi.org/10.1136/oem.2005.021204
Publication status	Published - 2006

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10.1136/oem.2005.021204

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@article{a417fd90119111df803f000ea68e967b,

title = "Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark",

abstract = "AIMS: To examine pregnancy outcomes in women doing laboratory work. METHODS: Using data from the Danish National Birth Cohort (1997-2003), the authors conducted a prospective cohort study of 1025 female laboratory technicians and 8037 female teachers (as reference). The laboratory technicians were asked about laboratory work tasks during pregnancy in an interview (at around 16 weeks of gestation). Pregnancy outcomes were obtained by linking the cohort to the national registers. Hazard ratios (HRs) of late fetal loss and diagnosing of congenital malformations were calculated by using Cox regression, and odds ratios (ORs) of preterm birth and small for gestational age were calculated by using logistic regression. RESULTS: Overall, there were no significant differences in pregnancy outcomes between laboratory technicians and teachers. However, we found that laboratory technicians working with radioimmunoassay or radiolabelling had an increased risk of preterm birth (OR = 2.2, 95% CI 0.8 to 6.2 for radioimmunoassay, and OR = 1.9, 95% CI 0.8 to 4.6 for radiolabelling) and {"}major{"} malformations (HR = 2.1, 95% CI 1.0 to 4.7 for radioimmunoassay, and HR = 1.8, 95% CI 0.9 to 3.7 for radiolabelling). The ORs of preterm birth doubled for women working with these tasks every day or several times a week. When an exposure matrix was applied, an increased risk of {"}major{"} malformations for exposure to organic solvents was seen. CONCLUSIONS: The results did not indicate any high risk of reproductive failures in laboratory technicians in general. Exposure to radioisotopes may carry a high risk of preterm birth and congenital malformations. This finding deserves further investigation.",

author = "Zhu, {J L} and Knudsen, {Lisbeth E.} and Andersen, {Anne-Marie Nybo} and Hjollund, {N H} and J{\o}rn Olsen",

note = "Keywords: Adult; Cohort Studies; Congenital Abnormalities; Denmark; Female; Fetal Death; Humans; Infant, Newborn; Infant, Small for Gestational Age; Laboratory Personnel; Male; Occupational Exposure; Pregnancy; Pregnancy Outcome; Premature Birth; Prenatal Exposure Delayed Effects; Proportional Hazards Models; Radioisotopes",

year = "2006",

doi = "10.1136/oem.2005.021204",

language = "English",

volume = "63",

pages = "53--8",

journal = "Occupational and Environmental Medicine",

issn = "1351-0711",

publisher = "B M J Group",

number = "1",

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TY - JOUR

T1 - Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

AU - Zhu, J L

AU - Knudsen, Lisbeth E.

AU - Andersen, Anne-Marie Nybo

AU - Hjollund, N H

AU - Olsen, Jørn

N1 - Keywords: Adult; Cohort Studies; Congenital Abnormalities; Denmark; Female; Fetal Death; Humans; Infant, Newborn; Infant, Small for Gestational Age; Laboratory Personnel; Male; Occupational Exposure; Pregnancy; Pregnancy Outcome; Premature Birth; Prenatal Exposure Delayed Effects; Proportional Hazards Models; Radioisotopes

PY - 2006

Y1 - 2006

N2 - AIMS: To examine pregnancy outcomes in women doing laboratory work. METHODS: Using data from the Danish National Birth Cohort (1997-2003), the authors conducted a prospective cohort study of 1025 female laboratory technicians and 8037 female teachers (as reference). The laboratory technicians were asked about laboratory work tasks during pregnancy in an interview (at around 16 weeks of gestation). Pregnancy outcomes were obtained by linking the cohort to the national registers. Hazard ratios (HRs) of late fetal loss and diagnosing of congenital malformations were calculated by using Cox regression, and odds ratios (ORs) of preterm birth and small for gestational age were calculated by using logistic regression. RESULTS: Overall, there were no significant differences in pregnancy outcomes between laboratory technicians and teachers. However, we found that laboratory technicians working with radioimmunoassay or radiolabelling had an increased risk of preterm birth (OR = 2.2, 95% CI 0.8 to 6.2 for radioimmunoassay, and OR = 1.9, 95% CI 0.8 to 4.6 for radiolabelling) and "major" malformations (HR = 2.1, 95% CI 1.0 to 4.7 for radioimmunoassay, and HR = 1.8, 95% CI 0.9 to 3.7 for radiolabelling). The ORs of preterm birth doubled for women working with these tasks every day or several times a week. When an exposure matrix was applied, an increased risk of "major" malformations for exposure to organic solvents was seen. CONCLUSIONS: The results did not indicate any high risk of reproductive failures in laboratory technicians in general. Exposure to radioisotopes may carry a high risk of preterm birth and congenital malformations. This finding deserves further investigation.

AB - AIMS: To examine pregnancy outcomes in women doing laboratory work. METHODS: Using data from the Danish National Birth Cohort (1997-2003), the authors conducted a prospective cohort study of 1025 female laboratory technicians and 8037 female teachers (as reference). The laboratory technicians were asked about laboratory work tasks during pregnancy in an interview (at around 16 weeks of gestation). Pregnancy outcomes were obtained by linking the cohort to the national registers. Hazard ratios (HRs) of late fetal loss and diagnosing of congenital malformations were calculated by using Cox regression, and odds ratios (ORs) of preterm birth and small for gestational age were calculated by using logistic regression. RESULTS: Overall, there were no significant differences in pregnancy outcomes between laboratory technicians and teachers. However, we found that laboratory technicians working with radioimmunoassay or radiolabelling had an increased risk of preterm birth (OR = 2.2, 95% CI 0.8 to 6.2 for radioimmunoassay, and OR = 1.9, 95% CI 0.8 to 4.6 for radiolabelling) and "major" malformations (HR = 2.1, 95% CI 1.0 to 4.7 for radioimmunoassay, and HR = 1.8, 95% CI 0.9 to 3.7 for radiolabelling). The ORs of preterm birth doubled for women working with these tasks every day or several times a week. When an exposure matrix was applied, an increased risk of "major" malformations for exposure to organic solvents was seen. CONCLUSIONS: The results did not indicate any high risk of reproductive failures in laboratory technicians in general. Exposure to radioisotopes may carry a high risk of preterm birth and congenital malformations. This finding deserves further investigation.

U2 - 10.1136/oem.2005.021204

DO - 10.1136/oem.2005.021204

M3 - Journal article

C2 - 16361406

SN - 1351-0711

VL - 63

SP - 53

EP - 58

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

IS - 1

ER -

Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

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