Abstract
Several drugs have a QTc-prolonging effect and are metabolized by CYP3A4. The combination of QTc-prolonging drugs may act additive of the QTc interval. The risk increases additionally by co-administration of a CYP3A4-inhibiting substrate. This case report describes an incident with QTc prolongation which was probably caused by an interaction induced by a combination of amiodarone, clarithromycin and the CYP3A4-inhibitor fluconazole.
| Translated title of the contribution | Combination therapy with fluconazole and other QTc-prolonging drugs increase the QTc interval |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for Laeger |
| Volume | 177 |
| Issue number | 41 |
| Pages (from-to) | V04150371 |
| ISSN | 0041-5782 |
| Publication status | Published - 5 Oct 2015 |
Keywords
- English Abstract
- Journal Article