Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: A cross-sectional study

TY - JOUR

T1 - Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis

T2 - A cross-sectional study

AU - Ballegaard, C

AU - Riis, R G C

AU - Bliddal, H

AU - Christensen, R

AU - Henriksen, M

AU - Bartels, E M

AU - Lohmander, L S

AU - Hunter, D J

AU - Bouert, R

AU - Boesen, M

N1 - Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

PY - 2014/7

Y1 - 2014/7

N2 - Objective: To investigate the association between knee pain and signs of inflammation in the infrapatellar fat pad (IPFP) in obese patients with knee osteoarthritis (KOA). Design: In a cross-sectional setting, 3-Tconventional contrast-enhanced (CE) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI of KOA were analysed to quantify the extent of inflammation in the IPFP, and correlated (Spearman's rank correlation) to pain and other symptoms assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (100=no pain, 0=extreme pain). The extent of inflammation in the IPFP was assessed according to the MRI Osteoarthritis Knee Score (MOAKS) using CE-MRI and by DCE-MRI perfusion variables. The perfusion variable, "Inflammation", was chosen as primary perfusion variable in the analysis. Intraclass correlation coefficients for the perfusion variables ranged from 0.81 to 0.99. Results: MRI and clinical data were obtained in 95 patients. The typical patient was a woman (82%) with an average age of 65 years (SD 6.5) and a body mass index (BMI) of 32kg/m2 (SD 3.7). The bivariate association between KOOS pain and the DCE-MRI perfusion variable "Inflammation" showed a statistically significant correlation (r=-0.42, P<0.0001). A statistically significant correlation was also found between KOOS pain and MOAKS Hoffa-synovitis (r=-0.21, P=0.046). Conclusions: Perfusion variables on DCE-MRI reflecting the severity of inflammation in the IPFP and MOAKS Hoffa-synovitis were associated with the severity of pain in KOA. These results suggest that severe inflammation in the IPFP is associated with severe pain in KOA and that DCE-MRI is a promising method to study the impact of inflammation in KOA.

AB - Objective: To investigate the association between knee pain and signs of inflammation in the infrapatellar fat pad (IPFP) in obese patients with knee osteoarthritis (KOA). Design: In a cross-sectional setting, 3-Tconventional contrast-enhanced (CE) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI of KOA were analysed to quantify the extent of inflammation in the IPFP, and correlated (Spearman's rank correlation) to pain and other symptoms assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (100=no pain, 0=extreme pain). The extent of inflammation in the IPFP was assessed according to the MRI Osteoarthritis Knee Score (MOAKS) using CE-MRI and by DCE-MRI perfusion variables. The perfusion variable, "Inflammation", was chosen as primary perfusion variable in the analysis. Intraclass correlation coefficients for the perfusion variables ranged from 0.81 to 0.99. Results: MRI and clinical data were obtained in 95 patients. The typical patient was a woman (82%) with an average age of 65 years (SD 6.5) and a body mass index (BMI) of 32kg/m2 (SD 3.7). The bivariate association between KOOS pain and the DCE-MRI perfusion variable "Inflammation" showed a statistically significant correlation (r=-0.42, P<0.0001). A statistically significant correlation was also found between KOOS pain and MOAKS Hoffa-synovitis (r=-0.21, P=0.046). Conclusions: Perfusion variables on DCE-MRI reflecting the severity of inflammation in the IPFP and MOAKS Hoffa-synovitis were associated with the severity of pain in KOA. These results suggest that severe inflammation in the IPFP is associated with severe pain in KOA and that DCE-MRI is a promising method to study the impact of inflammation in KOA.

KW - Adipose Tissue

KW - Aged

KW - Arthralgia

KW - Body Mass Index

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Knee Joint

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Obesity

KW - Osteoarthritis, Knee

KW - Outcome Assessment (Health Care)

KW - Patella

KW - Severity of Illness Index

KW - Software

KW - Synovitis

U2 - 10.1016/j.joca.2014.04.018

DO - 10.1016/j.joca.2014.04.018

M3 - Journal article

C2 - 24821663

SN - 1063-4584

VL - 22

SP - 933

EP - 940

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 7

ER -