Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry

Maria Pippias; Kitty J Jager; Fergus Caskey; Anna Casula; Helen Erlandsson; Patrik Finne; James Heaf; Georg Heinze; Andries Hoitsma; Reinhard Kramar; Marko Lempinen; Angela Magaz; Karsten Midtvedt; Lisa L Mumford; Julio Pascual; Karl G Prütz; Søren S Sørensen; Jamie P Traynor; Ziad A Massy; Rommel Ravanan; Vianda S Stel

doi:10.1111/tri.13103

Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry

Maria Pippias, Kitty J Jager, Fergus Caskey, Anna Casula, Helen Erlandsson, Patrik Finne, James Heaf, Georg Heinze, Andries Hoitsma, Reinhard Kramar, Marko Lempinen, Angela Magaz, Karsten Midtvedt, Lisa L Mumford, Julio Pascual, Karl G Prütz, Søren S Sørensen, Jamie P Traynor, Ziad A Massy, Rommel RavananVianda S Stel

Department of Clinical Medicine

8 Citations (Scopus)

Abstract

As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years) and group 2; younger (41 years) and older (60 years). A total of 1410 adults were transplanted during 2000-2007. Compared to the older recipients, the mean number of functioning graft years at 10 years was 6 months longer in the group 1 and group 2 younger recipients (P < 0.001). Ten-year graft survival was 54% and 40% for the group 1 younger and older recipients, and 60% and 49% for the group 2 younger and older recipients. Paired Cox regression analyses showed a lower risk of graft failure (group 1 younger; adjusted relative risk [RRa]:0.57, 95% CI:0.41-0.79, and group 2 younger; RRa:0.63, 95% CI:0.47-0.85) in younger recipients. Outcomes from older deceased donor allografts transplanted into differing donor-recipient age groups are better than previously reported. These allografts remain a valuable transplant resource, particularly for similar-aged recipients.

Original language	English
Journal	Transplant International
Volume	31
Issue number	7
Pages (from-to)	708-719
ISSN	0934-0874
DOIs	https://doi.org/10.1111/tri.13103
Publication status	Published - Jul 2018

Keywords

Adult
Age Factors
Aged
Cohort Studies
Europe/epidemiology
Female
Graft Survival
Humans
Kidney Transplantation/mortality
Male
Middle Aged
Registries
Tissue Donors

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Pippias, M., Jager, K. J., Caskey, F., Casula, A., Erlandsson, H., Finne, P., Heaf, J., Heinze, G., Hoitsma, A., Kramar, R., Lempinen, M., Magaz, A., Midtvedt, K., Mumford, L. L., Pascual, J., Prütz, K. G., Sørensen, S. S., Traynor, J. P., Massy, Z. A., ... Stel, V. S. (2018). Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry. Transplant International, 31(7), 708-719. https://doi.org/10.1111/tri.13103

Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry. / Pippias, Maria; Jager, Kitty J; Caskey, Fergus et al.
In: Transplant International, Vol. 31, No. 7, 07.2018, p. 708-719.

Research output: Contribution to journal › Journal article › Research › peer-review

Pippias, M, Jager, KJ, Caskey, F, Casula, A, Erlandsson, H, Finne, P, Heaf, J, Heinze, G, Hoitsma, A, Kramar, R, Lempinen, M, Magaz, A, Midtvedt, K, Mumford, LL, Pascual, J, Prütz, KG, Sørensen, SS, Traynor, JP, Massy, ZA, Ravanan, R & Stel, VS 2018, 'Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry', Transplant International, vol. 31, no. 7, pp. 708-719. https://doi.org/10.1111/tri.13103

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abstract = "As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years) and group 2; younger (41 years) and older (60 years). A total of 1410 adults were transplanted during 2000-2007. Compared to the older recipients, the mean number of functioning graft years at 10 years was 6 months longer in the group 1 and group 2 younger recipients (P < 0.001). Ten-year graft survival was 54% and 40% for the group 1 younger and older recipients, and 60% and 49% for the group 2 younger and older recipients. Paired Cox regression analyses showed a lower risk of graft failure (group 1 younger; adjusted relative risk [RRa]:0.57, 95% CI:0.41-0.79, and group 2 younger; RRa:0.63, 95% CI:0.47-0.85) in younger recipients. Outcomes from older deceased donor allografts transplanted into differing donor-recipient age groups are better than previously reported. These allografts remain a valuable transplant resource, particularly for similar-aged recipients.",

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T2 - a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry

AU - Pippias, Maria

AU - Jager, Kitty J

AU - Caskey, Fergus

AU - Casula, Anna

AU - Erlandsson, Helen

AU - Finne, Patrik

AU - Heaf, James

AU - Heinze, Georg

AU - Hoitsma, Andries

AU - Kramar, Reinhard

AU - Lempinen, Marko

AU - Magaz, Angela

AU - Midtvedt, Karsten

AU - Mumford, Lisa L

AU - Pascual, Julio

AU - Prütz, Karl G

AU - Sørensen, Søren S

AU - Traynor, Jamie P

AU - Massy, Ziad A

AU - Ravanan, Rommel

AU - Stel, Vianda S

PY - 2018/7

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N2 - As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years) and group 2; younger (41 years) and older (60 years). A total of 1410 adults were transplanted during 2000-2007. Compared to the older recipients, the mean number of functioning graft years at 10 years was 6 months longer in the group 1 and group 2 younger recipients (P < 0.001). Ten-year graft survival was 54% and 40% for the group 1 younger and older recipients, and 60% and 49% for the group 2 younger and older recipients. Paired Cox regression analyses showed a lower risk of graft failure (group 1 younger; adjusted relative risk [RRa]:0.57, 95% CI:0.41-0.79, and group 2 younger; RRa:0.63, 95% CI:0.47-0.85) in younger recipients. Outcomes from older deceased donor allografts transplanted into differing donor-recipient age groups are better than previously reported. These allografts remain a valuable transplant resource, particularly for similar-aged recipients.

AB - As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years) and group 2; younger (41 years) and older (60 years). A total of 1410 adults were transplanted during 2000-2007. Compared to the older recipients, the mean number of functioning graft years at 10 years was 6 months longer in the group 1 and group 2 younger recipients (P < 0.001). Ten-year graft survival was 54% and 40% for the group 1 younger and older recipients, and 60% and 49% for the group 2 younger and older recipients. Paired Cox regression analyses showed a lower risk of graft failure (group 1 younger; adjusted relative risk [RRa]:0.57, 95% CI:0.41-0.79, and group 2 younger; RRa:0.63, 95% CI:0.47-0.85) in younger recipients. Outcomes from older deceased donor allografts transplanted into differing donor-recipient age groups are better than previously reported. These allografts remain a valuable transplant resource, particularly for similar-aged recipients.

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KW - Age Factors

KW - Aged

KW - Cohort Studies

KW - Europe/epidemiology

KW - Female

KW - Graft Survival

KW - Humans

KW - Kidney Transplantation/mortality

KW - Male

KW - Middle Aged

KW - Registries

KW - Tissue Donors

U2 - 10.1111/tri.13103

DO - 10.1111/tri.13103

M3 - Journal article

C2 - 29210108

SN - 0934-0874

VL - 31

SP - 708

EP - 719

JO - Transplant International

JF - Transplant International

IS - 7

ER -

Kidney transplant outcomes from older deceased donors: a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry

Abstract

Keywords

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