Kidney anomalies diagnosed by prenatal ultrasound screening and associated non-urinary malformations: a nationwide prevalence study

TY - JOUR

T1 - Kidney anomalies diagnosed by prenatal ultrasound screening and associated non-urinary malformations

T2 - a nationwide prevalence study

AU - Rasmussen, Maria

AU - Olsen, Morten Smaerup

AU - Sunde, Lone

AU - Sperling, Lene Søndergård

AU - Danish Fetal Medicine Research Group

AU - Petersen, Olav Bjørn

N1 - © 2016 John Wiley & Sons, Ltd.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objectives: To estimate the prevalence of kidney anomalies at second trimester ultrasound screening, and furthermore, to investigate pregnancy outcomes and the pattern of additional malformations. Methods: We previously identified all women attending second-trimester ultrasound scans in Denmark between 1 January 2007 and 31 December 2012. Using the Astraia databases and the Danish National Patient Registry, we identified all fetuses with kidney anomalies diagnosed prenatally in these women. In addition to the prevalence of fetuses with kidney anomalies, we estimated the live birth prevalence ratio of non-urinary malformations, comparing the prevalences in infants with and without prenatally diagnosed kidney anomalies. Results: The prevalence of fetuses with kidney anomalies at second trimester scans was 11.4 per 10 000 fetuses. Among the 412 fetuses identified, 127 pregnancies were terminated. For live born children the prevalence of additional non-urinary malformations was four times higher (95% CI: 3–5) compared with the prevalence among children without prenatal kidney anomalies. Digestive system anomalies were particularly prevalent. Conclusion: These population-based data provide additional insight into the course of pregnancy and birth outcomes following prenatal diagnoses of kidney anomalies.

AB - Objectives: To estimate the prevalence of kidney anomalies at second trimester ultrasound screening, and furthermore, to investigate pregnancy outcomes and the pattern of additional malformations. Methods: We previously identified all women attending second-trimester ultrasound scans in Denmark between 1 January 2007 and 31 December 2012. Using the Astraia databases and the Danish National Patient Registry, we identified all fetuses with kidney anomalies diagnosed prenatally in these women. In addition to the prevalence of fetuses with kidney anomalies, we estimated the live birth prevalence ratio of non-urinary malformations, comparing the prevalences in infants with and without prenatally diagnosed kidney anomalies. Results: The prevalence of fetuses with kidney anomalies at second trimester scans was 11.4 per 10 000 fetuses. Among the 412 fetuses identified, 127 pregnancies were terminated. For live born children the prevalence of additional non-urinary malformations was four times higher (95% CI: 3–5) compared with the prevalence among children without prenatal kidney anomalies. Digestive system anomalies were particularly prevalent. Conclusion: These population-based data provide additional insight into the course of pregnancy and birth outcomes following prenatal diagnoses of kidney anomalies.

KW - Chromosome Aberrations/statistics & numerical data

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Kidney/abnormalities

KW - Pregnancy

KW - Pregnancy Trimester, Second

KW - Prevalence

KW - Ultrasonography, Prenatal

KW - Urogenital Abnormalities/diagnostic imaging

U2 - 10.1002/pd.4871

DO - 10.1002/pd.4871

M3 - Journal article

C2 - 27381563

SN - 0197-3851

VL - 36

SP - 847

EP - 853

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 9

ER -