Staphylococcus aureus and the ecology of the nasal microbiome

Cindy M Liu; Lance B Price; Bruce A Hungate; Alison G Abraham; Lisbeth A. Larsen; Kaare Christensen; Marc Stegger; Robert Skov; Paal Skytt Andersen

doi:10.1126/sciadv.1400216

Staphylococcus aureus and the ecology of the nasal microbiome

Cindy M Liu, Lance B Price, Bruce A Hungate, Alison G Abraham, Lisbeth A. Larsen, Kaare Christensen, Marc Stegger, Robert Skov, Paal Skytt Andersen

Food Safety and Zoonoses

99 Citations (Scopus)

97 Downloads (Pure)

Abstract

The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

Original language	English
Article number	e1400216
Journal	Science Advances
Volume	1
Issue number	5
Number of pages	7
ISSN	2375-2548
DOIs	https://doi.org/10.1126/sciadv.1400216
Publication status	Published - Jun 2015

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Staphylococcus aureus and the ecology of the nasal microbiomeFinal published version, 451 KBLicence: CC BY-NC

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title = "Staphylococcus aureus and the ecology of the nasal microbiome",

abstract = "The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.",

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AU - Liu, Cindy M

AU - Price, Lance B

AU - Hungate, Bruce A

AU - Abraham, Alison G

AU - Larsen, Lisbeth A.

AU - Christensen, Kaare

AU - Stegger, Marc

AU - Skov, Robert

AU - Andersen, Paal Skytt

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N2 - The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

AB - The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

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DO - 10.1126/sciadv.1400216

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SN - 2375-2548

VL - 1

JO - Science advances

JF - Science advances

IS - 5

M1 - e1400216

ER -

Staphylococcus aureus and the ecology of the nasal microbiome

Abstract

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