Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Slobodan Culina; Ana Ines Lalanne; Georgia Afonso; Karen Cerosaletti; Sheena Pinto; Guido Sebastiani; Klaudia Kuranda; Laura Nigi; Anne Eugster; Thomas Osterbye; Alicia Maugein; James E. McLaren; Kristin Ladell; Etienne Larger; Jean-Paul Beressi; Anna Lissina; Victor Appay; Howard W. Davidson; Soren Buus; David A. Price; Matthias Kuhn; Ezio Bonifacio; Manuela Battaglia; Sophie Caillat-Zucman; Francesco Dotta; Raphael Scharfmann; Bruno Kyewski; Roberto Mallone

doi:10.1126/sciimmunol.aao4013

Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Osterbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Soren Buus, David A. PriceMatthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Francesco Dotta, Raphael Scharfmann, Bruno Kyewski, Roberto Mallone

71 Citations (Scopus)

Original language	English
Article number	eaao4013
Journal	Science immunology
Volume	3
Issue number	20
ISSN	2470-9468
DOIs	https://doi.org/10.1126/sciimmunol.aao4013
Publication status	Published - 2018

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Culina, S., Lalanne, A. I., Afonso, G., Cerosaletti, K., Pinto, S., Sebastiani, G., Kuranda, K., Nigi, L., Eugster, A., Osterbye, T., Maugein, A., McLaren, J. E., Ladell, K., Larger, E., Beressi, J-P., Lissina, A., Appay, V., Davidson, H. W., Buus, S., ... Mallone, R. (2018). Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science immunology, 3(20), [eaao4013]. https://doi.org/10.1126/sciimmunol.aao4013

Culina, S, Lalanne, AI, Afonso, G, Cerosaletti, K, Pinto, S, Sebastiani, G, Kuranda, K, Nigi, L, Eugster, A, Osterbye, T, Maugein, A, McLaren, JE, Ladell, K, Larger, E, Beressi, J-P, Lissina, A, Appay, V, Davidson, HW, Buus, S, Price, DA, Kuhn, M, Bonifacio, E, Battaglia, M, Caillat-Zucman, S, Dotta, F, Scharfmann, R, Kyewski, B & Mallone, R 2018, 'Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors', Science immunology, vol. 3, no. 20, eaao4013. https://doi.org/10.1126/sciimmunol.aao4013

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title = "Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors",

author = "Slobodan Culina and Lalanne, {Ana Ines} and Georgia Afonso and Karen Cerosaletti and Sheena Pinto and Guido Sebastiani and Klaudia Kuranda and Laura Nigi and Anne Eugster and Thomas Osterbye and Alicia Maugein and McLaren, {James E.} and Kristin Ladell and Etienne Larger and Jean-Paul Beressi and Anna Lissina and Victor Appay and Davidson, {Howard W.} and Soren Buus and Price, {David A.} and Matthias Kuhn and Ezio Bonifacio and Manuela Battaglia and Sophie Caillat-Zucman and Francesco Dotta and Raphael Scharfmann and Bruno Kyewski and Roberto Mallone",

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doi = "10.1126/sciimmunol.aao4013",

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T1 - Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

AU - Culina, Slobodan

AU - Lalanne, Ana Ines

AU - Afonso, Georgia

AU - Cerosaletti, Karen

AU - Pinto, Sheena

AU - Sebastiani, Guido

AU - Kuranda, Klaudia

AU - Nigi, Laura

AU - Eugster, Anne

AU - Osterbye, Thomas

AU - Maugein, Alicia

AU - McLaren, James E.

AU - Ladell, Kristin

AU - Larger, Etienne

AU - Beressi, Jean-Paul

AU - Lissina, Anna

AU - Appay, Victor

AU - Davidson, Howard W.

AU - Buus, Soren

AU - Price, David A.

AU - Kuhn, Matthias

AU - Bonifacio, Ezio

AU - Battaglia, Manuela

AU - Caillat-Zucman, Sophie

AU - Dotta, Francesco

AU - Scharfmann, Raphael

AU - Kyewski, Bruno

AU - Mallone, Roberto

PY - 2018

Y1 - 2018

U2 - 10.1126/sciimmunol.aao4013

DO - 10.1126/sciimmunol.aao4013

M3 - Journal article

C2 - 29429978

SN - 0065-2776

VL - 3

JO - Advances in Immunology

JF - Advances in Immunology

IS - 20

M1 - eaao4013

ER -

Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

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