Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

Anna Jäger; D.M. Knap; Birgitte Nielsen; G. I. Stafford; J. van Staden

doi:10.1016/j.sajb.2011.10.002

Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

Anna Jäger, D.M. Knap, Birgitte Nielsen, G. I. Stafford, J. van Staden

2 Citations (Scopus)

Abstract

Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.

Original language	English
Journal	South African Journal of Botany
Volume	78
Pages (from-to)	312–314
Number of pages	3
ISSN	0254-6299
DOIs	https://doi.org/10.1016/j.sajb.2011.10.002
Publication status	Published - Jan 2012

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title = "Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor",

abstract = "Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.",

author = "Anna J{\"a}ger and D.M. Knap and Birgitte Nielsen and Stafford, {G. I.} and {van Staden}, J.",

year = "2012",

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doi = "10.1016/j.sajb.2011.10.002",

language = "English",

volume = "78",

pages = "312–314",

journal = "South African Journal of Botany",

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T1 - Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

AU - Jäger, Anna

AU - Knap, D.M.

AU - Nielsen, Birgitte

AU - Stafford, G. I.

AU - van Staden, J.

PY - 2012/1

Y1 - 2012/1

N2 - Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.

AB - Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.

U2 - 10.1016/j.sajb.2011.10.002

DO - 10.1016/j.sajb.2011.10.002

M3 - Letter

SN - 0254-6299

VL - 78

SP - 312

EP - 314

JO - South African Journal of Botany

JF - South African Journal of Botany

ER -

Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

Abstract

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