Is immunotherapy-induced birch-pollen-specific IgG4 a marker for decreased allergen-specific sensitivity?

TY - JOUR

T1 - Is immunotherapy-induced birch-pollen-specific IgG4 a marker for decreased allergen-specific sensitivity?

AU - Bodtger, U

AU - Ejrnaes, A M

AU - Hummelshoj, L

AU - Jacobi, H H

AU - Poulsen, Lars K.

AU - Svenson, M

N1 - Copyright (c) 2005 S. Karger AG, Basel

PY - 2005

Y1 - 2005

N2 - The role of IgG4 during allergen-specific immunotherapy (SIT) is still controversial. The available studies present paramount differences in in vitro techniques, allergens, and clinical outcome parameters. By implementing a sensitive method, and pivotal clinical outcome parameters, we wanted to ascertain the utility of IgG4 as a clinical marker of decreased allergen-specific sensitivity to a common aeroallergen.

AB - The role of IgG4 during allergen-specific immunotherapy (SIT) is still controversial. The available studies present paramount differences in in vitro techniques, allergens, and clinical outcome parameters. By implementing a sensitive method, and pivotal clinical outcome parameters, we wanted to ascertain the utility of IgG4 as a clinical marker of decreased allergen-specific sensitivity to a common aeroallergen.

KW - Betula

KW - Biological Markers

KW - Humans

KW - Hypersensitivity

KW - Immunoglobulin E

KW - Immunoglobulin G

KW - Pollen

U2 - 10.1159/000084227

DO - 10.1159/000084227

M3 - Journal article

C2 - 15741732

SN - 1018-2438

VL - 136

SP - 340

EP - 346

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

IS - 4

ER -