Abstract
Duodenal adenomas are a frequent extracolonic manifestation in patients with familial polyposis coli (FPC). Epidermal growth factor (EGF), a polypeptide that stimulates cellular growth and differentiation, is localized in Paneth cells in the small intestine. In two patients with FPC, we found EGF immunoreactivity in duodenal adenomas. Numerous EGF immunoreactive Paneth cells were localized, not as usually, in the bottom of the crypts, but scattered along the crypts alone or in clusters. We do not know whether EGF is involved in the development of duodenal polyps in FPC patients, or whether the present findings represent secondary changes in duodenal polyps.
| Original language | English |
|---|---|
| Journal | The American Journal of Gastroenterology |
| Volume | 83 |
| Issue number | 4 |
| Pages (from-to) | 404-6 |
| Number of pages | 3 |
| ISSN | 0002-9270 |
| Publication status | Published - Apr 1988 |
Keywords
- Adenoma
- Adenomatous Polyposis Coli
- Adult
- Duodenal Neoplasms
- Duodenum
- Epidermal Growth Factor
- Female
- Humans
- Hyperplasia
- Intestinal Mucosa
- Intestinal Polyps
- Male
- Neoplasms, Multiple Primary