Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study

TY - JOUR

T1 - Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study

AU - Meluken, Iselin

AU - Ottesen, Ninja M

AU - Harmer, C J

AU - Scheike, Thomas

AU - Kessing, Lars Vedel

AU - Vinberg, Maj

AU - Miskowiak, Kamilla Woznica

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins with no family history of affective disorder (i.e. low-risk).Methods We conducted an assessor blind cross-sectional study from 2014 to 2017 of MZ twins using Danish population-based registers in recruitment. Twins attended one test session involving neurocognitive testing, clinical ratings and questionnaires. Main outcomes were attention to and recognition of emotional facial expressions, the memory of emotional self-referential words, emotion regulation and coping strategies.Results Participants were 103 affected, 44 high-risk and 36 low-risk MZ twins. Groups were demographically well-balanced and showed comparable non-affective cognitive performance. We observed no aberrant affective cognition in affected and high-risk relative to low-risk twins. However, high-risk twins displayed attentional avoidance of emotional faces (ps 1/2 0.009) and more use of task-oriented coping strategies (p = 0.01) compared with affected twins. In contrast did affected twins show more emotion-oriented coping than high-A nd low-risk twins (ps -1/2 0.004).Conclusions Our findings provide no support of aberrant affective cognition as an endophenotype for affective disorders. High-risk twins' attentional avoidance of emotional faces and greater use of task-oriented coping strategies may reflect compensatory mechanisms.

AB - Background Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins with no family history of affective disorder (i.e. low-risk).Methods We conducted an assessor blind cross-sectional study from 2014 to 2017 of MZ twins using Danish population-based registers in recruitment. Twins attended one test session involving neurocognitive testing, clinical ratings and questionnaires. Main outcomes were attention to and recognition of emotional facial expressions, the memory of emotional self-referential words, emotion regulation and coping strategies.Results Participants were 103 affected, 44 high-risk and 36 low-risk MZ twins. Groups were demographically well-balanced and showed comparable non-affective cognitive performance. We observed no aberrant affective cognition in affected and high-risk relative to low-risk twins. However, high-risk twins displayed attentional avoidance of emotional faces (ps 1/2 0.009) and more use of task-oriented coping strategies (p = 0.01) compared with affected twins. In contrast did affected twins show more emotion-oriented coping than high-A nd low-risk twins (ps -1/2 0.004).Conclusions Our findings provide no support of aberrant affective cognition as an endophenotype for affective disorders. High-risk twins' attentional avoidance of emotional faces and greater use of task-oriented coping strategies may reflect compensatory mechanisms.

KW - Faculty of Social Sciences

KW - Affective cognition

KW - affective disorder

KW - emotion processing

KW - emotion regulation

KW - endophenotype

KW - twin study

U2 - 10.1017/S0033291718001642

DO - 10.1017/S0033291718001642

M3 - Journal article

C2 - 29962367

SN - 0033-2917

VL - 49

SP - 987

EP - 996

JO - Psychological Medicine

JF - Psychological Medicine

IS - 6

ER -