Ion channels and transporters in the development of drug resistance in cancer cells

TY - JOUR

T1 - Ion channels and transporters in the development of drug resistance in cancer cells

AU - Hoffmann, Else Kay

AU - Lambert, Ian Henry

N1 - Theme Issue "Ion channels, transporters and cancer"

PY - 2014/3/19

Y1 - 2014/3/19

N2 - Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis.

AB - Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis.

UR - http://www.scopus.com/inward/record.url?scp=84893464588&partnerID=8YFLogxK

U2 - 10.1098/rstb.2013.0109

DO - 10.1098/rstb.2013.0109

M3 - Journal article

C2 - 24493757

AN - SCOPUS:84893464588

SN - 0962-8436

VL - 369

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

IS - 1638

ER -