Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs.

Lise Nikolic Nielsen; Fintan McEvoy; Lisbeth Rem Jessen; Annemarie Thuri Kristensen

doi:10.1111/j.1476-5829.2011.00285.x

Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs.

Lise Nikolic Nielsen, Fintan McEvoy, Lisbeth Rem Jessen, Annemarie Thuri Kristensen

9 Citations (Scopus)

Abstract

The aim of the study was to construct a screening programme for disseminated histiocytic sarcoma (DHS) in Bernese Mountain dogs using diagnostic imaging and blood analysis and evaluate blood borne biomarkers as early disease detection biomarkers. Healthy Bernese Mountain dogs were screened on four occasions in an attempt to detect early disease. Eleven blood borne biomarkers were examined for their worth as early tumour biomarkers. During 2.5 years, five dogs with early DHS were identified; four of these by diagnostic imaging. No dogs developed symptomatic DHS without being detected within 6 months of the screening programme. Only serum ferritin showed potential as a blood borne marker of the disease. Median survival times for the dogs with early DHS were 226 days. Screening programmes every 6 months for Bernese Mountain dogs over 4 years of age including diagnostic imaging and ferritin measurements may identify early DHS.

Original language	English
Journal	Veterinary and Comparative Oncology
Volume	10
Issue number	2
Pages (from-to)	124-134
Number of pages	11
ISSN	1476-5810
DOIs	https://doi.org/10.1111/j.1476-5829.2011.00285.x
Publication status	Published - Jun 2012

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Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs. / Nielsen, Lise Nikolic ; McEvoy, Fintan ; Jessen, Lisbeth Rem et al.
In: Veterinary and Comparative Oncology, Vol. 10, No. 2, 06.2012, p. 124-134.

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Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs.

Abstract

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