Intratumoral Interleukin-21 Increases Antitumor Immunity, Tumor-infiltrating CD8(+) T-cell Density and Activity, and Enlarges Draining Lymph Nodes

Immunology and Microbiology

• Carcinoma Cell 8%
• CD25 16%
• CD4 16%
• CD8 16%
• Cell Activity 100%
• Cell Density 100%
• Cytokine 8%
• Cytotoxic T-Cell 100%
• Degranulation 8%
• Granzyme B 8%
• Interferon 8%
• Interleukin 21 100%
• Lymph Node 100%
• Lymphocyte 16%
• Syngenic 8%
• T Cell 16%
• T Cell Proliferation 8%
• Tumor Immunity 100%

Keyphrases

• Activated Lymphocytes 8%
• Antitumor Efficacy 8%
• B16 Melanoma 8%
• Cancer Treatment 8%
• CD25 8%
• CD4+ 8%
• CD4+CD25+ T Cells 8%
• CD8+ 8%
• CD8+ T 25%
• CD8+ T Cells 8%
• Cell Proliferation 8%
• Cell-mediated 8%
• Clinical Development 8%
• Degranulation 8%
• Effector Function 16%
• Granzyme B 8%
• Improved Survival 8%
• Increased Density 8%
• Interleukin-21 (IL-21) 100%
• Local Administration 8%
• Lymphocyte Count 8%
• Lymphocyte Proliferation 8%
• Renal Cell Carcinoma 8%
• Renca 8%
• Subcutaneous Administration 16%
• Syngeneic Mouse Model 8%
• Systemic Effects 8%
• T Cells 8%
• Tumor 8%
• Tumor Growth 8%
• Tumor Immunity 100%
• Tumor Microenvironment 8%
• Tumor-draining Lymph Nodes 100%
• Tumor-infiltrating 8%