Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography

Graziano Vignolini; Francesco Sessa; Isabella Greco; Gianmartin Cito; Davide Vanacore; Andrea Cocci; Maurizio Sessa; Vieri Grandi; Alessandro Pili; Saverio Giancane; Mauro Gacci; Arcangelo Sebastianelli; Vincenzo Li Marzi; Alberto Breda; Riccardo Campi; Sergio Serni

doi:10.23736/S0393-2249.18.03278-2

Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography

Graziano Vignolini, Francesco Sessa, Isabella Greco, Gianmartin Cito, Davide Vanacore, Andrea Cocci, Maurizio Sessa, Vieri Grandi, Alessandro Pili, Saverio Giancane, Mauro Gacci, Arcangelo Sebastianelli, Vincenzo Li Marzi, Alberto Breda, Riccardo Campi^*, Sergio Serni

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

BACKGROUND: The aim of this paper is to report the first preliminary experience with intraoperative indocyanine green (ICG) fluorescence videography (IFV) to assess graft and ureteral reperfusion during robot-assisted kidney transplantation (RAKT). METHODS: We prospectively collected data from consecutive patients undergoing RAKT and IFV from living-donors at our Institution between January 2017 and April 2018. RAKT was performed following the principles of the Vattikuti-Medanta technique. ICG was injected intravenously after vascular anastomoses to quantitate graft and ureteral fluorescence signal. The signal intensity within selected intraoperative snapshots was evaluated for renal parenchyma, ureter and vascular anastomoses. A systematic review of the English-language literature about the topic was performed according to the PRISMA statement recommendations. RESULTS: Six patients were included. Neither conversions to open surgery nor major intra- or postoperative complications were recorded. At a median follow-up of 12 months (IQR 8-13), median estimated glomerular filtration rate was 64.2 mL/min/1.73 m ² (IQR 45.3-98.4). Intraoperative quantitative assessment of ICG fluorescence was successful in all patients. Of the five studies selected by our review, mostly prospective studies, all including open KT series. Yet, most studies were limited by lack of quantitative measures of IFV fluorescence. CONCLUSIONS: IFV during RAKT is feasible and safe and provides a reliable assessment of graft reperfusion. Larger studies are needed to standardize the technique and to evaluate the association between fluorescence signal, ultrasound parameters and postoperative kidney function.

Original language	English
Journal	Minerva Urologica e Nefrologica
Volume	71
Issue number	1
Pages (from-to)	79-84
Number of pages	6
ISSN	0393-2249
DOIs	https://doi.org/10.23736/S0393-2249.18.03278-2
Publication status	Published - 1 Feb 2019

Keywords

Fluorescence
Kidney transplantation
Reperfusion
Robotics

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10.23736/S0393-2249.18.03278-2

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Vignolini, G., Sessa, F., Greco, I., Cito, G., Vanacore, D., Cocci, A., Sessa, M., Grandi, V., Pili, A., Giancane, S., Gacci, M., Sebastianelli, A., Li Marzi, V., Breda, A., Campi, R., & Serni, S. (2019). Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography. Minerva Urologica e Nefrologica, 71(1), 79-84. https://doi.org/10.23736/S0393-2249.18.03278-2

Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography. / Vignolini, Graziano; Sessa, Francesco; Greco, Isabella et al.
In: Minerva Urologica e Nefrologica, Vol. 71, No. 1, 01.02.2019, p. 79-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Vignolini, G, Sessa, F, Greco, I, Cito, G, Vanacore, D, Cocci, A, Sessa, M, Grandi, V, Pili, A, Giancane, S, Gacci, M, Sebastianelli, A, Li Marzi, V, Breda, A, Campi, R & Serni, S 2019, 'Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography', Minerva Urologica e Nefrologica, vol. 71, no. 1, pp. 79-84. https://doi.org/10.23736/S0393-2249.18.03278-2

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title = "Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography",

abstract = " BACKGROUND: The aim of this paper is to report the first preliminary experience with intraoperative indocyanine green (ICG) fluorescence videography (IFV) to assess graft and ureteral reperfusion during robot-assisted kidney transplantation (RAKT). METHODS: We prospectively collected data from consecutive patients undergoing RAKT and IFV from living-donors at our Institution between January 2017 and April 2018. RAKT was performed following the principles of the Vattikuti-Medanta technique. ICG was injected intravenously after vascular anastomoses to quantitate graft and ureteral fluorescence signal. The signal intensity within selected intraoperative snapshots was evaluated for renal parenchyma, ureter and vascular anastomoses. A systematic review of the English-language literature about the topic was performed according to the PRISMA statement recommendations. RESULTS: Six patients were included. Neither conversions to open surgery nor major intra- or postoperative complications were recorded. At a median follow-up of 12 months (IQR 8-13), median estimated glomerular filtration rate was 64.2 mL/min/1.73 m 2 (IQR 45.3-98.4). Intraoperative quantitative assessment of ICG fluorescence was successful in all patients. Of the five studies selected by our review, mostly prospective studies, all including open KT series. Yet, most studies were limited by lack of quantitative measures of IFV fluorescence. CONCLUSIONS: IFV during RAKT is feasible and safe and provides a reliable assessment of graft reperfusion. Larger studies are needed to standardize the technique and to evaluate the association between fluorescence signal, ultrasound parameters and postoperative kidney function. ",

keywords = "Fluorescence, Kidney transplantation, Reperfusion, Robotics",

author = "Graziano Vignolini and Francesco Sessa and Isabella Greco and Gianmartin Cito and Davide Vanacore and Andrea Cocci and Maurizio Sessa and Vieri Grandi and Alessandro Pili and Saverio Giancane and Mauro Gacci and Arcangelo Sebastianelli and {Li Marzi}, Vincenzo and Alberto Breda and Riccardo Campi and Sergio Serni",

year = "2019",

month = feb,

day = "1",

doi = "10.23736/S0393-2249.18.03278-2",

language = "English",

volume = "71",

pages = "79--84",

journal = "Minerva Urologica e Nefrologica",

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TY - JOUR

T1 - Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography

AU - Vignolini, Graziano

AU - Sessa, Francesco

AU - Greco, Isabella

AU - Cito, Gianmartin

AU - Vanacore, Davide

AU - Cocci, Andrea

AU - Sessa, Maurizio

AU - Grandi, Vieri

AU - Pili, Alessandro

AU - Giancane, Saverio

AU - Gacci, Mauro

AU - Sebastianelli, Arcangelo

AU - Li Marzi, Vincenzo

AU - Breda, Alberto

AU - Campi, Riccardo

AU - Serni, Sergio

PY - 2019/2/1

Y1 - 2019/2/1

N2 - BACKGROUND: The aim of this paper is to report the first preliminary experience with intraoperative indocyanine green (ICG) fluorescence videography (IFV) to assess graft and ureteral reperfusion during robot-assisted kidney transplantation (RAKT). METHODS: We prospectively collected data from consecutive patients undergoing RAKT and IFV from living-donors at our Institution between January 2017 and April 2018. RAKT was performed following the principles of the Vattikuti-Medanta technique. ICG was injected intravenously after vascular anastomoses to quantitate graft and ureteral fluorescence signal. The signal intensity within selected intraoperative snapshots was evaluated for renal parenchyma, ureter and vascular anastomoses. A systematic review of the English-language literature about the topic was performed according to the PRISMA statement recommendations. RESULTS: Six patients were included. Neither conversions to open surgery nor major intra- or postoperative complications were recorded. At a median follow-up of 12 months (IQR 8-13), median estimated glomerular filtration rate was 64.2 mL/min/1.73 m 2 (IQR 45.3-98.4). Intraoperative quantitative assessment of ICG fluorescence was successful in all patients. Of the five studies selected by our review, mostly prospective studies, all including open KT series. Yet, most studies were limited by lack of quantitative measures of IFV fluorescence. CONCLUSIONS: IFV during RAKT is feasible and safe and provides a reliable assessment of graft reperfusion. Larger studies are needed to standardize the technique and to evaluate the association between fluorescence signal, ultrasound parameters and postoperative kidney function.

AB - BACKGROUND: The aim of this paper is to report the first preliminary experience with intraoperative indocyanine green (ICG) fluorescence videography (IFV) to assess graft and ureteral reperfusion during robot-assisted kidney transplantation (RAKT). METHODS: We prospectively collected data from consecutive patients undergoing RAKT and IFV from living-donors at our Institution between January 2017 and April 2018. RAKT was performed following the principles of the Vattikuti-Medanta technique. ICG was injected intravenously after vascular anastomoses to quantitate graft and ureteral fluorescence signal. The signal intensity within selected intraoperative snapshots was evaluated for renal parenchyma, ureter and vascular anastomoses. A systematic review of the English-language literature about the topic was performed according to the PRISMA statement recommendations. RESULTS: Six patients were included. Neither conversions to open surgery nor major intra- or postoperative complications were recorded. At a median follow-up of 12 months (IQR 8-13), median estimated glomerular filtration rate was 64.2 mL/min/1.73 m 2 (IQR 45.3-98.4). Intraoperative quantitative assessment of ICG fluorescence was successful in all patients. Of the five studies selected by our review, mostly prospective studies, all including open KT series. Yet, most studies were limited by lack of quantitative measures of IFV fluorescence. CONCLUSIONS: IFV during RAKT is feasible and safe and provides a reliable assessment of graft reperfusion. Larger studies are needed to standardize the technique and to evaluate the association between fluorescence signal, ultrasound parameters and postoperative kidney function.

KW - Fluorescence

KW - Kidney transplantation

KW - Reperfusion

KW - Robotics

U2 - 10.23736/S0393-2249.18.03278-2

DO - 10.23736/S0393-2249.18.03278-2

M3 - Journal article

C2 - 30421596

AN - SCOPUS:85061250742

SN - 0393-2249

VL - 71

SP - 79

EP - 84

JO - Minerva Urologica e Nefrologica

JF - Minerva Urologica e Nefrologica

IS - 1

ER -

Intraoperative assessment of ureteral and graft reperfusion during robotic kidney transplantation with indocyanine green fluorescence videography

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Keywords

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