Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease

Rasmus Sejersten Ripa; Yongzhong Wang; Erik Jørgensen; Hans Erik Johnsen; Birger Hesse; Jens Kastrup

doi:10.1093/eurheartj/ehl117

Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease

Rasmus Sejersten Ripa, Yongzhong Wang, Erik Jørgensen, Hans Erik Johnsen, Birger Hesse, Jens Kastrup

115 Citations (Scopus)

Abstract

To assess the safety and effects of combined treatment with vascular endothelial growth factor-A(165) plasmid (VEGF-A(165)) and granulocyte- colony stimulating factor (G-CSF) mobilization of bone marrow stem cells in patients with severe chronic ischaemic heart disease (IHD).

Original language	English
Journal	European Heart Journal
Volume	27
Issue number	15
Pages (from-to)	1785-92
Number of pages	8
ISSN	0195-668X
DOIs	https://doi.org/10.1093/eurheartj/ehl117
Publication status	Published - Aug 2006
Externally published	Yes

Keywords

Adolescent
Adult
Aged
Chronic Disease
Coronary Circulation
Drug Therapy, Combination
Female
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cell Mobilization
Humans
Injections, Intralesional
Magnetic Resonance Angiography
Male
Middle Aged
Myocardial Ischemia
Neovascularization, Physiologic
Prospective Studies
Recombinant Proteins
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Vascular Endothelial Growth Factor A

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10.1093/eurheartj/ehl117

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Ripa, R. S., Wang, Y., Jørgensen, E., Johnsen, H. E., Hesse, B., & Kastrup, J. (2006). Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease. European Heart Journal, 27(15), 1785-92. https://doi.org/10.1093/eurheartj/ehl117

Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease. / Ripa, Rasmus Sejersten; Wang, Yongzhong; Jørgensen, Erik et al.

In: European Heart Journal, Vol. 27, No. 15, 08.2006, p. 1785-92.

Research output: Contribution to journal › Journal article › Research › peer-review

Ripa, RS, Wang, Y, Jørgensen, E, Johnsen, HE, Hesse, B & Kastrup, J 2006, 'Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease', European Heart Journal, vol. 27, no. 15, pp. 1785-92. https://doi.org/10.1093/eurheartj/ehl117

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title = "Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease",

abstract = "To assess the safety and effects of combined treatment with vascular endothelial growth factor-A(165) plasmid (VEGF-A(165)) and granulocyte- colony stimulating factor (G-CSF) mobilization of bone marrow stem cells in patients with severe chronic ischaemic heart disease (IHD).",

keywords = "Adolescent, Adult, Aged, Chronic Disease, Coronary Circulation, Drug Therapy, Combination, Female, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization, Humans, Injections, Intralesional, Magnetic Resonance Angiography, Male, Middle Aged, Myocardial Ischemia, Neovascularization, Physiologic, Prospective Studies, Recombinant Proteins, Tomography, Emission-Computed, Single-Photon, Treatment Outcome, Vascular Endothelial Growth Factor A",

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doi = "10.1093/eurheartj/ehl117",

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AU - Jørgensen, Erik

AU - Johnsen, Hans Erik

AU - Hesse, Birger

AU - Kastrup, Jens

PY - 2006/8

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KW - Adult

KW - Aged

KW - Chronic Disease

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KW - Female

KW - Granulocyte Colony-Stimulating Factor

KW - Hematopoietic Stem Cell Mobilization

KW - Humans

KW - Injections, Intralesional

KW - Magnetic Resonance Angiography

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia

KW - Neovascularization, Physiologic

KW - Prospective Studies

KW - Recombinant Proteins

KW - Tomography, Emission-Computed, Single-Photon

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SN - 0195-668X

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EP - 1792

JO - European Heart Journal

JF - European Heart Journal

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