Intestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis

John Elmerdahl Olsen; Kirsten Hobolt Hoegh-Andersen; Jesper Tjørnhøj Rosenkrantz; Casper Schroll; Josep Casadesús; Søren Aabo; Jens Peter Christensen

doi:10.1016/j.vetmic.2013.04.008

Intestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis

John Elmerdahl Olsen, Kirsten Hobolt Hoegh-Andersen, Jesper Tjørnhøj Rosenkrantz, Casper Schroll, Josep Casadesús, Søren Aabo, Jens Peter Christensen

6 Citations (Scopus)

Abstract

Salmonella enterica serotype Typhimurium (S. Typhimurium) can invade in the intestine of the avian host, and knowledge on the mechanisms that govern this is potentially important for prevention of disease. This study investigated the invasion of S. Typhimurium in the avian host and to which extent it depended on motility and chemotaxis. Wild type and previously well-characterized transposon mutants in flagella genes fliC and fljB and in chemotaxis genes cheA, cheB and cheR were used as challenge strains in intestinal loop experiments. Invasion was shown to be dose dependent, but did not require functional flagella or chemotaxis genes. In support of the results from intestinal loop experiments, flagella and chemotaxis genes were not significantly important to the outcome of an oral infection. The results showed that S. Typhimurium invasion in the avian host was dose dependent and was not affected by the loss of flagella and chemotaxis genes.

Original language	English
Journal	Veterinary Microbiology
Volume	165
Issue number	3-4
Pages (from-to)	373-377
Number of pages	5
ISSN	0378-1135
DOIs	https://doi.org/10.1016/j.vetmic.2013.04.008
Publication status	Published - 30 Aug 2013

Keywords

Faculty of Health and Medical Sciences

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Intestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis. / Olsen, John Elmerdahl; Hoegh-Andersen, Kirsten Hobolt; Rosenkrantz, Jesper Tjørnhøj et al.

In: Veterinary Microbiology, Vol. 165, No. 3-4, 30.08.2013, p. 373-377.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Intestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis",

abstract = "Salmonella enterica serotype Typhimurium (S. Typhimurium) can invade in the intestine of the avian host, and knowledge on the mechanisms that govern this is potentially important for prevention of disease. This study investigated the invasion of S. Typhimurium in the avian host and to which extent it depended on motility and chemotaxis. Wild type and previously well-characterized transposon mutants in flagella genes fliC and fljB and in chemotaxis genes cheA, cheB and cheR were used as challenge strains in intestinal loop experiments. Invasion was shown to be dose dependent, but did not require functional flagella or chemotaxis genes. In support of the results from intestinal loop experiments, flagella and chemotaxis genes were not significantly important to the outcome of an oral infection. The results showed that S. Typhimurium invasion in the avian host was dose dependent and was not affected by the loss of flagella and chemotaxis genes.",

keywords = "Faculty of Health and Medical Sciences, Salmonella, virulens, invasion, Dose–response, Flagella, Chemotaxis",

author = "Olsen, {John Elmerdahl} and Hoegh-Andersen, {Kirsten Hobolt} and Rosenkrantz, {Jesper Tj{\o}rnh{\o}j} and Casper Schroll and Josep Casades{\'u}s and S{\o}ren Aabo and Christensen, {Jens Peter}",

year = "2013",

month = aug,

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doi = "10.1016/j.vetmic.2013.04.008",

language = "English",

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journal = "Veterinary Microbiology",

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T1 - Intestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis

AU - Olsen, John Elmerdahl

AU - Hoegh-Andersen, Kirsten Hobolt

AU - Rosenkrantz, Jesper Tjørnhøj

AU - Schroll, Casper

AU - Casadesús, Josep

AU - Aabo, Søren

AU - Christensen, Jens Peter

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Salmonella enterica serotype Typhimurium (S. Typhimurium) can invade in the intestine of the avian host, and knowledge on the mechanisms that govern this is potentially important for prevention of disease. This study investigated the invasion of S. Typhimurium in the avian host and to which extent it depended on motility and chemotaxis. Wild type and previously well-characterized transposon mutants in flagella genes fliC and fljB and in chemotaxis genes cheA, cheB and cheR were used as challenge strains in intestinal loop experiments. Invasion was shown to be dose dependent, but did not require functional flagella or chemotaxis genes. In support of the results from intestinal loop experiments, flagella and chemotaxis genes were not significantly important to the outcome of an oral infection. The results showed that S. Typhimurium invasion in the avian host was dose dependent and was not affected by the loss of flagella and chemotaxis genes.

AB - Salmonella enterica serotype Typhimurium (S. Typhimurium) can invade in the intestine of the avian host, and knowledge on the mechanisms that govern this is potentially important for prevention of disease. This study investigated the invasion of S. Typhimurium in the avian host and to which extent it depended on motility and chemotaxis. Wild type and previously well-characterized transposon mutants in flagella genes fliC and fljB and in chemotaxis genes cheA, cheB and cheR were used as challenge strains in intestinal loop experiments. Invasion was shown to be dose dependent, but did not require functional flagella or chemotaxis genes. In support of the results from intestinal loop experiments, flagella and chemotaxis genes were not significantly important to the outcome of an oral infection. The results showed that S. Typhimurium invasion in the avian host was dose dependent and was not affected by the loss of flagella and chemotaxis genes.

KW - Faculty of Health and Medical Sciences

KW - Salmonella

KW - virulens

KW - invasion

KW - Dose–response

KW - Flagella

KW - Chemotaxis

U2 - 10.1016/j.vetmic.2013.04.008

DO - 10.1016/j.vetmic.2013.04.008

M3 - Journal article

C2 - 23642416

SN - 0378-1135

VL - 165

SP - 373

EP - 377

JO - Veterinary Microbiology

JF - Veterinary Microbiology

IS - 3-4

ER -

Intestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis

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Keywords

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