Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

R Smolders; E Den Hond; G Koppen; E Govarts; H Willems; L Casteleyn; M Kolossa-Gehring; U Fiddicke; A Castaño; H M Koch; J Angerer; M Esteban; O Sepai; K Exley; L Bloemen; M Horvat; Lisbeth E. Knudsen; A Joas; R Joas; P Biot; D Aerts; A Katsonouri; A Hadjipanayis; M Cerna; A Krskova; G Schwedler; M Seiwert; J K S Nielsen; P Rudnai; S Közepesy; D S Evans; M P Ryan; A C Gutleb; M E Fischer; D Ligocka; M Jakubowski; M F Reis; S Namorado; I-R Lupsa; A E Gurzau; K Halzlova; E Fabianova; D Mazej; J Tratnik Snoj; S Gomez; S González; M Berglund; K Larsson; A Lehmann; P Crettaz; G Schoeters

doi:10.1016/j.envres.2014.08.016

Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

R Smolders, E Den Hond, G Koppen, E Govarts, H Willems, L Casteleyn, M Kolossa-Gehring, U Fiddicke, A Castaño, H M Koch, J Angerer, M Esteban, O Sepai, K Exley, L Bloemen, M Horvat, Lisbeth E. Knudsen, A Joas, R Joas, P BiotD Aerts, A Katsonouri, A Hadjipanayis, M Cerna, A Krskova, G Schwedler, M Seiwert, J K S Nielsen, P Rudnai, S Közepesy, D S Evans, M P Ryan, A C Gutleb, M E Fischer, D Ligocka, M Jakubowski, M F Reis, S Namorado, I-R Lupsa, A E Gurzau, K Halzlova, E Fabianova, D Mazej, J Tratnik Snoj, S Gomez, S González, M Berglund, K Larsson, A Lehmann, P Crettaz, G Schoeters

22 Citations (Scopus)

Abstract

In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.

Original language	English
Journal	Environmental Research
Volume	141
Pages (from-to)	86–95
Number of pages	10
ISSN	0013-9351
DOIs	https://doi.org/10.1016/j.envres.2014.08.016
Publication status	Published - 1 Aug 2015

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Smolders, R., Den Hond, E., Koppen, G., Govarts, E., Willems, H., Casteleyn, L., Kolossa-Gehring, M., Fiddicke, U., Castaño, A., Koch, H. M., Angerer, J., Esteban, M., Sepai, O., Exley, K., Bloemen, L., Horvat, M., Knudsen, L. E., Joas, A., Joas, R., ... Schoeters, G. (2015). Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries. Environmental Research, 141, 86–95. https://doi.org/10.1016/j.envres.2014.08.016

Smolders, R, Den Hond, E, Koppen, G, Govarts, E, Willems, H, Casteleyn, L, Kolossa-Gehring, M, Fiddicke, U, Castaño, A, Koch, HM, Angerer, J, Esteban, M, Sepai, O, Exley, K, Bloemen, L, Horvat, M, Knudsen, LE, Joas, A, Joas, R, Biot, P, Aerts, D, Katsonouri, A, Hadjipanayis, A, Cerna, M, Krskova, A, Schwedler, G, Seiwert, M, Nielsen, JKS, Rudnai, P, Közepesy, S, Evans, DS, Ryan, MP, Gutleb, AC, Fischer, ME, Ligocka, D, Jakubowski, M, Reis, MF, Namorado, S, Lupsa, I-R, Gurzau, AE, Halzlova, K, Fabianova, E, Mazej, D, Tratnik Snoj, J, Gomez, S, González, S, Berglund, M, Larsson, K, Lehmann, A, Crettaz, P & Schoeters, G 2015, 'Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries', Environmental Research, vol. 141, pp. 86–95. https://doi.org/10.1016/j.envres.2014.08.016

@article{90fce3112e384c8abc5fcbd8ee7bca2a,

title = "Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries",

abstract = "In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.",

author = "R Smolders and {Den Hond}, E and G Koppen and E Govarts and H Willems and L Casteleyn and M Kolossa-Gehring and U Fiddicke and A Casta{\~n}o and Koch, {H M} and J Angerer and M Esteban and O Sepai and K Exley and L Bloemen and M Horvat and Knudsen, {Lisbeth E.} and A Joas and R Joas and P Biot and D Aerts and A Katsonouri and A Hadjipanayis and M Cerna and A Krskova and G Schwedler and M Seiwert and Nielsen, {J K S} and P Rudnai and S K{\"o}zepesy and Evans, {D S} and Ryan, {M P} and Gutleb, {A C} and Fischer, {M E} and D Ligocka and M Jakubowski and Reis, {M F} and S Namorado and I-R Lupsa and Gurzau, {A E} and K Halzlova and E Fabianova and D Mazej and {Tratnik Snoj}, J and S Gomez and S Gonz{\'a}lez and M Berglund and K Larsson and A Lehmann and P Crettaz and G Schoeters",

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doi = "10.1016/j.envres.2014.08.016",

language = "English",

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pages = "86–95",

journal = "Environmental Research",

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T1 - Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects

T2 - Using external exposure data to understand biomarker differences among countries

AU - Smolders, R

AU - Den Hond, E

AU - Koppen, G

AU - Govarts, E

AU - Willems, H

AU - Casteleyn, L

AU - Kolossa-Gehring, M

AU - Fiddicke, U

AU - Castaño, A

AU - Koch, H M

AU - Angerer, J

AU - Esteban, M

AU - Sepai, O

AU - Exley, K

AU - Bloemen, L

AU - Horvat, M

AU - Knudsen, Lisbeth E.

AU - Joas, A

AU - Joas, R

AU - Biot, P

AU - Aerts, D

AU - Katsonouri, A

AU - Hadjipanayis, A

AU - Cerna, M

AU - Krskova, A

AU - Schwedler, G

AU - Seiwert, M

AU - Nielsen, J K S

AU - Rudnai, P

AU - Közepesy, S

AU - Evans, D S

AU - Ryan, M P

AU - Gutleb, A C

AU - Fischer, M E

AU - Ligocka, D

AU - Jakubowski, M

AU - Reis, M F

AU - Namorado, S

AU - Lupsa, I-R

AU - Gurzau, A E

AU - Halzlova, K

AU - Fabianova, E

AU - Mazej, D

AU - Tratnik Snoj, J

AU - Gomez, S

AU - González, S

AU - Berglund, M

AU - Larsson, K

AU - Lehmann, A

AU - Crettaz, P

AU - Schoeters, G

PY - 2015/8/1

Y1 - 2015/8/1

N2 - In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.

AB - In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.

U2 - 10.1016/j.envres.2014.08.016

DO - 10.1016/j.envres.2014.08.016

M3 - Journal article

C2 - 25440294

SN - 0013-9351

VL - 141

SP - 86

EP - 95

JO - Environmental Research

JF - Environmental Research

ER -

Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

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