International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Kaspar Matiasek; Martí Pumarola I Batlle; Marco Rosati; Francisco Fernández-Flores; Andrea Fischer; Eva Wagner; Mette Berendt; Sofie F M Bhatti; Luisa De Risio; Robyn G Farquhar; Sam Long; Karen Muñana; Edward E Patterson; Akos Pakozdy; Jacques Penderis; Simon Platt; Michael Podell; Heidrun Potschka; Clare Rusbridge; Veronika M Stein; Andrea Tipold; Holger A Volk

doi:10.1186/s12917-015-0467-9

International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Kaspar Matiasek, Martí Pumarola I Batlle, Marco Rosati, Francisco Fernández-Flores, Andrea Fischer, Eva Wagner, Mette Berendt, Sofie F M Bhatti, Luisa De Risio, Robyn G Farquhar, Sam Long, Karen Muñana, Edward E Patterson, Akos Pakozdy, Jacques Penderis, Simon Platt, Michael Podell, Heidrun Potschka, Clare Rusbridge, Veronika M SteinAndrea Tipold, Holger A Volk

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Abstract

Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

Original language	English
Article number	216
Journal	B M C Veterinary Research
Volume	11
Number of pages	28
ISSN	1746-6148
DOIs	https://doi.org/10.1186/s12917-015-0467-9
Publication status	Published - 28 Aug 2015

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International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and catsFinal published version, 7.66 MB

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Matiasek, K., Pumarola I Batlle, M., Rosati, M., Fernández-Flores, F., Fischer, A., Wagner, E., Berendt, M., Bhatti, S. F. M., De Risio, L., Farquhar, R. G., Long, S., Muñana, K., Patterson, E. E., Pakozdy, A., Penderis, J., Platt, S., Podell, M., Potschka, H., Rusbridge, C., ... Volk, H. A. (2015). International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats. B M C Veterinary Research, 11, [216]. https://doi.org/10.1186/s12917-015-0467-9

Matiasek, K, Pumarola I Batlle, M, Rosati, M, Fernández-Flores, F, Fischer, A, Wagner, E, Berendt, M, Bhatti, SFM, De Risio, L, Farquhar, RG, Long, S, Muñana, K, Patterson, EE, Pakozdy, A, Penderis, J, Platt, S, Podell, M, Potschka, H, Rusbridge, C, Stein, VM, Tipold, A & Volk, HA 2015, 'International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats', B M C Veterinary Research, vol. 11, 216. https://doi.org/10.1186/s12917-015-0467-9

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title = "International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats",

abstract = "Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.",

author = "Kaspar Matiasek and {Pumarola I Batlle}, Mart{\'i} and Marco Rosati and Francisco Fern{\'a}ndez-Flores and Andrea Fischer and Eva Wagner and Mette Berendt and Bhatti, {Sofie F M} and {De Risio}, Luisa and Farquhar, {Robyn G} and Sam Long and Karen Mu{\~n}ana and Patterson, {Edward E} and Akos Pakozdy and Jacques Penderis and Simon Platt and Michael Podell and Heidrun Potschka and Clare Rusbridge and Stein, {Veronika M} and Andrea Tipold and Volk, {Holger A}",

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T1 - International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

AU - Matiasek, Kaspar

AU - Pumarola I Batlle, Martí

AU - Rosati, Marco

AU - Fernández-Flores, Francisco

AU - Fischer, Andrea

AU - Wagner, Eva

AU - Berendt, Mette

AU - Bhatti, Sofie F M

AU - De Risio, Luisa

AU - Farquhar, Robyn G

AU - Long, Sam

AU - Muñana, Karen

AU - Patterson, Edward E

AU - Pakozdy, Akos

AU - Penderis, Jacques

AU - Platt, Simon

AU - Podell, Michael

AU - Potschka, Heidrun

AU - Rusbridge, Clare

AU - Stein, Veronika M

AU - Tipold, Andrea

AU - Volk, Holger A

PY - 2015/8/28

Y1 - 2015/8/28

N2 - Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

AB - Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

U2 - 10.1186/s12917-015-0467-9

DO - 10.1186/s12917-015-0467-9

M3 - Journal article

C2 - 26324339

SN - 1746-6148

VL - 11

JO - B M C Veterinary Research

JF - B M C Veterinary Research

M1 - 216

ER -

International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Abstract

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