Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells.

TY - JOUR

T1 - Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells.

AU - Thulesen, S

AU - Nielsen, M

AU - Petersen, T R

AU - Holst Nissen, M

AU - Ødum, Niels

AU - Röpke, C

N1 - Keywords: CD8-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Gene Expression Regulation; Humans; Interleukin-15; Interleukin-2; Receptors, Interleukin-15; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes

PY - 2000

Y1 - 2000

N2 - The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.

AB - The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.

U2 - 10.1006/cyto.1999.0608

DO - 10.1006/cyto.1999.0608

M3 - Journal article

C2 - 10843758

SN - 1043-4666

VL - 12

SP - 751

EP - 755

JO - Cytokine

JF - Cytokine

IS - 6

ER -