Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

Otto M. Henriksen; Mark Bitsch Vestergaard; Ulrich Lindberg; Niels Jacob Aachmann-Andersen; Kristian Lisbjerg; Søren Just Christensen; Peter Rasmussen; Niels Vidiendal Olsen; Julie L. Forman; Henrik Bo Wiberg Larsson; Ian Law

doi:10.1152/japplphysiol.00276.2018

Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

Otto M. Henriksen, Mark Bitsch Vestergaard, Ulrich Lindberg, Niels Jacob Aachmann-Andersen, Kristian Lisbjerg, Søren Just Christensen, Peter Rasmussen, Niels Vidiendal Olsen, Julie L. Forman, Henrik Bo Wiberg Larsson, Ian Law

4 Citations (Scopus)

Abstract

Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationships between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young men using dynamic [15O]H2O and [18F]fluorodeoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO²) were obtained b.combined susceptometry-based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc, and gCMRO2 were observed. Linear mixed-model analysis showed a highly significant association of CBF with CMRglc regionally. Compared with neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami, and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism. NEW & NOTEWORTHY Using method-independent techniques the study cannot confirm direct interindividual correlations of absolute global values of perfusion with oxygen or glucose metabolism in the resting brain, and absolute global perfusion measurements appear not to be valid surrogate measures of cerebral metabolism. The ratio of both perfusion and oxygen delivery to glucose metabolism varies regionally, also when accounting for known methodological regional bias in quantification of glucose metabolism.

Original language	English
Journal	Journal of Applied Physiology
Volume	125
Pages (from-to)	1080-1089
Number of pages	10
ISSN	8750-7587
DOIs	https://doi.org/10.1152/japplphysiol.00276.2018
Publication status	Published - Oct 2018

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Henriksen, O. M., Vestergaard, M. B., Lindberg, U., Aachmann-Andersen, N. J., Lisbjerg, K., Christensen, S. J., Rasmussen, P., Olsen, N. V., Forman, J. L., Larsson, H. B. W., & Law, I. (2018). Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain. Journal of Applied Physiology, 125, 1080-1089. https://doi.org/10.1152/japplphysiol.00276.2018

Henriksen, OM, Vestergaard, MB, Lindberg, U, Aachmann-Andersen, NJ, Lisbjerg, K, Christensen, SJ, Rasmussen, P, Olsen, NV, Forman, JL , Larsson, HBW & Law, I 2018, 'Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain', Journal of Applied Physiology, vol. 125, pp. 1080-1089. https://doi.org/10.1152/japplphysiol.00276.2018

@article{48c7880735d74d3990aa3af01dbd9ee0,

title = "Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain",

abstract = "Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationships between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young men using dynamic [15O]H2O and [18F]fluorodeoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO2) were obtained b.combined susceptometry-based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc, and gCMRO2 were observed. Linear mixed-model analysis showed a highly significant association of CBF with CMRglc regionally. Compared with neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami, and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism. NEW & NOTEWORTHY Using method-independent techniques the study cannot confirm direct interindividual correlations of absolute global values of perfusion with oxygen or glucose metabolism in the resting brain, and absolute global perfusion measurements appear not to be valid surrogate measures of cerebral metabolism. The ratio of both perfusion and oxygen delivery to glucose metabolism varies regionally, also when accounting for known methodological regional bias in quantification of glucose metabolism.",

author = "Henriksen, {Otto M.} and Vestergaard, {Mark Bitsch} and Ulrich Lindberg and Aachmann-Andersen, {Niels Jacob} and Kristian Lisbjerg and Christensen, {S{\o}ren Just} and Peter Rasmussen and Olsen, {Niels Vidiendal} and Forman, {Julie L.} and Larsson, {Henrik Bo Wiberg} and Ian Law",

year = "2018",

month = oct,

doi = "10.1152/japplphysiol.00276.2018",

language = "English",

volume = "125",

pages = "1080--1089",

journal = "Journal of Applied Physiology",

issn = "8750-7587",

publisher = "American Physiological Society",

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TY - JOUR

T1 - Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

AU - Henriksen, Otto M.

AU - Vestergaard, Mark Bitsch

AU - Lindberg, Ulrich

AU - Aachmann-Andersen, Niels Jacob

AU - Lisbjerg, Kristian

AU - Christensen, Søren Just

AU - Rasmussen, Peter

AU - Olsen, Niels Vidiendal

AU - Forman, Julie L.

AU - Larsson, Henrik Bo Wiberg

AU - Law, Ian

PY - 2018/10

Y1 - 2018/10

N2 - Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationships between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young men using dynamic [15O]H2O and [18F]fluorodeoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO2) were obtained b.combined susceptometry-based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc, and gCMRO2 were observed. Linear mixed-model analysis showed a highly significant association of CBF with CMRglc regionally. Compared with neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami, and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism. NEW & NOTEWORTHY Using method-independent techniques the study cannot confirm direct interindividual correlations of absolute global values of perfusion with oxygen or glucose metabolism in the resting brain, and absolute global perfusion measurements appear not to be valid surrogate measures of cerebral metabolism. The ratio of both perfusion and oxygen delivery to glucose metabolism varies regionally, also when accounting for known methodological regional bias in quantification of glucose metabolism.

AB - Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationships between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young men using dynamic [15O]H2O and [18F]fluorodeoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO2) were obtained b.combined susceptometry-based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc, and gCMRO2 were observed. Linear mixed-model analysis showed a highly significant association of CBF with CMRglc regionally. Compared with neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami, and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism. NEW & NOTEWORTHY Using method-independent techniques the study cannot confirm direct interindividual correlations of absolute global values of perfusion with oxygen or glucose metabolism in the resting brain, and absolute global perfusion measurements appear not to be valid surrogate measures of cerebral metabolism. The ratio of both perfusion and oxygen delivery to glucose metabolism varies regionally, also when accounting for known methodological regional bias in quantification of glucose metabolism.

U2 - 10.1152/japplphysiol.00276.2018

DO - 10.1152/japplphysiol.00276.2018

M3 - Journal article

C2 - 29975605

SN - 8750-7587

VL - 125

SP - 1080

EP - 1089

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

ER -

Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

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