Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance

Trine Juhler-Nøttrup; Stine Sofia Korreman; Anders N Pedersen; Gitte F Persson; Lasse R Aarup; Håkan Nyström; Mikael Olsen; Nikolai Tarnavski; Lena Specht; Lasse Rye Aarup

doi:10.1080/02841860802258778

Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance

Trine Juhler-Nøttrup, Stine Sofia Korreman, Anders N Pedersen, Gitte F Persson, Lasse R Aarup, Håkan Nyström, Mikael Olsen, Nikolai Tarnavski, Lena Specht, Lasse Rye Aarup

49 Citations (Scopus)

Abstract

INTRODUCTION: With the purpose of implementing gated radiotherapy for lung cancer patients, this study investigated the interfraction variations in tumour size and internal displacement over entire treatment courses. To explore the potential of image guided radiotherapy (IGRT) the variations were measured using a set-up strategy based on imaging of bony landmarks and compared to a strategy using in room lasers, skin tattoos and cupper landmarks. MATERIALS AND METHODS: During their six week treatment course of 60Gy in 2Gy fractions, ten patients underwent 3 respiratory gated CT scans. The tumours were contoured on each CT scan to evaluate the variations in volumes and position. The lung tumours and the mediastinal tumours were contoured separately. The positional variations were measured as 3D mobility vectors and correlated to matching of the scans using the two different strategies. RESULTS: The tumour size was significantly reduced from the first to the last CT scan. For the lung tumours the reduction was 19%, p=0.03, and for the mediastinal tumours the reduction was 34%, p=0.0007. The mean 3D mobility vector and the SD for the lung tumours was 0.51 cm (+/-0.21) for matching using bony landmarks and 0.85 cm (+/-0.54) for matching using skin tattoos. For the mediastinal tumours the corresponding vectors and SD's were 0.55 cm (+/-0.19) and 0.72 cm (+/-0.43). The differences between the vectors were significant for the lung tumours p=0.004. The interfractional overlap of lung tumours was 80-87% when matched using bony landmarks and 70-76% when matched using skin tattoos. The overlap of the mediastinal tumours were 60-65% and 41-47%, respectively. CONCLUSIONS: Despite the use of gating the tumours varied considerably, regarding both position and volume. The variations in position were dependent on the set-up strategy. Set-up using IGRT was superior to set-up using skin tattoos.

Original language	English
Journal	Acta Oncologica
Volume	47
Issue number	7
Pages (from-to)	1406-13
Number of pages	8
ISSN	0284-186X
DOIs	https://doi.org/10.1080/02841860802258778 https://doi.org/10.1080/02841860802258778
Publication status	Published - 1 Jan 2008

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Juhler-Nøttrup, T., Korreman, S. S., Pedersen, A. N., Persson, G. F., Aarup, L. R., Nyström, H., Olsen, M., Tarnavski, N., Specht, L., & Aarup, L. R. (2008). Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance. Acta Oncologica, 47(7), 1406-13. https://doi.org/10.1080/02841860802258778, https://doi.org/10.1080/02841860802258778

Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance. / Juhler-Nøttrup, Trine; Korreman, Stine Sofia; Pedersen, Anders N et al.

In: Acta Oncologica, Vol. 47, No. 7, 01.01.2008, p. 1406-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Juhler-Nøttrup, T, Korreman, SS, Pedersen, AN, Persson, GF, Aarup, LR, Nyström, H, Olsen, M, Tarnavski, N, Specht, L & Aarup, LR 2008, 'Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance', Acta Oncologica, vol. 47, no. 7, pp. 1406-13. https://doi.org/10.1080/02841860802258778, https://doi.org/10.1080/02841860802258778

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title = "Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance",

abstract = "INTRODUCTION: With the purpose of implementing gated radiotherapy for lung cancer patients, this study investigated the interfraction variations in tumour size and internal displacement over entire treatment courses. To explore the potential of image guided radiotherapy (IGRT) the variations were measured using a set-up strategy based on imaging of bony landmarks and compared to a strategy using in room lasers, skin tattoos and cupper landmarks. MATERIALS AND METHODS: During their six week treatment course of 60Gy in 2Gy fractions, ten patients underwent 3 respiratory gated CT scans. The tumours were contoured on each CT scan to evaluate the variations in volumes and position. The lung tumours and the mediastinal tumours were contoured separately. The positional variations were measured as 3D mobility vectors and correlated to matching of the scans using the two different strategies. RESULTS: The tumour size was significantly reduced from the first to the last CT scan. For the lung tumours the reduction was 19%, p=0.03, and for the mediastinal tumours the reduction was 34%, p=0.0007. The mean 3D mobility vector and the SD for the lung tumours was 0.51 cm (+/-0.21) for matching using bony landmarks and 0.85 cm (+/-0.54) for matching using skin tattoos. For the mediastinal tumours the corresponding vectors and SD's were 0.55 cm (+/-0.19) and 0.72 cm (+/-0.43). The differences between the vectors were significant for the lung tumours p=0.004. The interfractional overlap of lung tumours was 80-87% when matched using bony landmarks and 70-76% when matched using skin tattoos. The overlap of the mediastinal tumours were 60-65% and 41-47%, respectively. CONCLUSIONS: Despite the use of gating the tumours varied considerably, regarding both position and volume. The variations in position were dependent on the set-up strategy. Set-up using IGRT was superior to set-up using skin tattoos.",

author = "Trine Juhler-N{\o}ttrup and Korreman, {Stine Sofia} and Pedersen, {Anders N} and Persson, {Gitte F} and Aarup, {Lasse R} and H{\aa}kan Nystr{\"o}m and Mikael Olsen and Nikolai Tarnavski and Lena Specht and Aarup, {Lasse Rye}",

note = "Keywords: Aged; Female; Humans; Lung Neoplasms; Male; Mediastinal Neoplasms; Middle Aged; Respiratory Physiological Phenomena; Tattooing; Tomography, X-Ray Computed; Tumor Burden",

year = "2008",

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doi = "10.1080/02841860802258778",

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T1 - Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance

AU - Juhler-Nøttrup, Trine

AU - Korreman, Stine Sofia

AU - Pedersen, Anders N

AU - Persson, Gitte F

AU - Aarup, Lasse R

AU - Nyström, Håkan

AU - Olsen, Mikael

AU - Tarnavski, Nikolai

AU - Specht, Lena

AU - Aarup, Lasse Rye

N1 - Keywords: Aged; Female; Humans; Lung Neoplasms; Male; Mediastinal Neoplasms; Middle Aged; Respiratory Physiological Phenomena; Tattooing; Tomography, X-Ray Computed; Tumor Burden

PY - 2008/1/1

Y1 - 2008/1/1

N2 - INTRODUCTION: With the purpose of implementing gated radiotherapy for lung cancer patients, this study investigated the interfraction variations in tumour size and internal displacement over entire treatment courses. To explore the potential of image guided radiotherapy (IGRT) the variations were measured using a set-up strategy based on imaging of bony landmarks and compared to a strategy using in room lasers, skin tattoos and cupper landmarks. MATERIALS AND METHODS: During their six week treatment course of 60Gy in 2Gy fractions, ten patients underwent 3 respiratory gated CT scans. The tumours were contoured on each CT scan to evaluate the variations in volumes and position. The lung tumours and the mediastinal tumours were contoured separately. The positional variations were measured as 3D mobility vectors and correlated to matching of the scans using the two different strategies. RESULTS: The tumour size was significantly reduced from the first to the last CT scan. For the lung tumours the reduction was 19%, p=0.03, and for the mediastinal tumours the reduction was 34%, p=0.0007. The mean 3D mobility vector and the SD for the lung tumours was 0.51 cm (+/-0.21) for matching using bony landmarks and 0.85 cm (+/-0.54) for matching using skin tattoos. For the mediastinal tumours the corresponding vectors and SD's were 0.55 cm (+/-0.19) and 0.72 cm (+/-0.43). The differences between the vectors were significant for the lung tumours p=0.004. The interfractional overlap of lung tumours was 80-87% when matched using bony landmarks and 70-76% when matched using skin tattoos. The overlap of the mediastinal tumours were 60-65% and 41-47%, respectively. CONCLUSIONS: Despite the use of gating the tumours varied considerably, regarding both position and volume. The variations in position were dependent on the set-up strategy. Set-up using IGRT was superior to set-up using skin tattoos.

AB - INTRODUCTION: With the purpose of implementing gated radiotherapy for lung cancer patients, this study investigated the interfraction variations in tumour size and internal displacement over entire treatment courses. To explore the potential of image guided radiotherapy (IGRT) the variations were measured using a set-up strategy based on imaging of bony landmarks and compared to a strategy using in room lasers, skin tattoos and cupper landmarks. MATERIALS AND METHODS: During their six week treatment course of 60Gy in 2Gy fractions, ten patients underwent 3 respiratory gated CT scans. The tumours were contoured on each CT scan to evaluate the variations in volumes and position. The lung tumours and the mediastinal tumours were contoured separately. The positional variations were measured as 3D mobility vectors and correlated to matching of the scans using the two different strategies. RESULTS: The tumour size was significantly reduced from the first to the last CT scan. For the lung tumours the reduction was 19%, p=0.03, and for the mediastinal tumours the reduction was 34%, p=0.0007. The mean 3D mobility vector and the SD for the lung tumours was 0.51 cm (+/-0.21) for matching using bony landmarks and 0.85 cm (+/-0.54) for matching using skin tattoos. For the mediastinal tumours the corresponding vectors and SD's were 0.55 cm (+/-0.19) and 0.72 cm (+/-0.43). The differences between the vectors were significant for the lung tumours p=0.004. The interfractional overlap of lung tumours was 80-87% when matched using bony landmarks and 70-76% when matched using skin tattoos. The overlap of the mediastinal tumours were 60-65% and 41-47%, respectively. CONCLUSIONS: Despite the use of gating the tumours varied considerably, regarding both position and volume. The variations in position were dependent on the set-up strategy. Set-up using IGRT was superior to set-up using skin tattoos.

U2 - 10.1080/02841860802258778

DO - 10.1080/02841860802258778

M3 - Journal article

C2 - 18686049

SN - 1100-1704

VL - 47

SP - 1406

EP - 1413

JO - Acta Oncologica, Supplement

JF - Acta Oncologica, Supplement

IS - 7

ER -

Interfractional changes in tumour volume and position during entire radiotherapy courses for lung cancer with respiratory gating and image guidance

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