Interbreed variation of biomarkers of lipid and glucose metabolism in dogs

Carlos Gomez-fernandez-blanco; Dominique Peeters; Evelyne Moyse; Frédéric Farnir; Katja Höglund; Vassiliki Gouni; Maria Wiberg; Jakob Lundgren Willesen; Sofia Hanås; Kathleen Mcentee; Laurent Tiret; Jens Häggström; Hannes Lohi; Valérie Chetboul; Merete Fredholm; Eija H Seppälä; Anne-sophie Lequarré; Anne-christine Merveille

doi:10.1111/vcp.12673

Interbreed variation of biomarkers of lipid and glucose metabolism in dogs

Carlos Gomez-fernandez-blanco, Dominique Peeters, Evelyne Moyse, Frédéric Farnir, Katja Höglund, Vassiliki Gouni, Maria Wiberg, Jakob Lundgren Willesen, Sofia Hanås, Kathleen Mcentee, Laurent Tiret, Jens Häggström, Hannes Lohi, Valérie Chetboul, Merete Fredholm, Eija H Seppälä, Anne-sophie Lequarré, Anne-christine Merveille

2 Citations (Scopus)

Abstract

Background
Markers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species‐specific reference intervals, but interbreed variation can also affect data interpretation.

Objectives
The purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds.

Methods
We analyzed a database containing information on biochemical variables from 534 dogs belonging to nine different breeds. All dogs were confirmed to be healthy based on history, physical examination, and ancillary tests. Concentrations of glucose, fructosamine, insulin, cholesterol, triglycerides, fatty acids, and C‐reactive protein were compared using the nonparametric Kruskal–Wallis and Dunn's tests.

Results
All variables tested showed significant interbreed differences, although all breeds remained within the previously established RIs for dogs. Fructosamine, insulin, and cholesterol showed a wide interbreed variation that could affect the interpretation of results.

Conclusions
Breed is an important factor to consider when assessing energy metabolism in dogs, especially for markers like fructosamine, insulin, and cholesterol, which vary considerably among breeds.

Original language	English
Journal	Veterinary Clinical Pathology
Volume	47
Issue number	4
Pages (from-to)	582-588
ISSN	0275-6382
DOIs	https://doi.org/10.1111/vcp.12673
Publication status	Published - Dec 2018

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10.1111/vcp.12673

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Gomez-fernandez-blanco, C., Peeters, D., Moyse, E., Farnir, F., Höglund, K., Gouni, V., Wiberg, M., Lundgren Willesen, J., Hanås, S., Mcentee, K., Tiret, L., Häggström, J., Lohi, H., Chetboul, V., Fredholm, M., Seppälä, E. H., Lequarré, A., & Merveille, A. (2018). Interbreed variation of biomarkers of lipid and glucose metabolism in dogs. Veterinary Clinical Pathology, 47(4), 582-588. https://doi.org/10.1111/vcp.12673

Gomez-fernandez-blanco, C, Peeters, D, Moyse, E, Farnir, F, Höglund, K, Gouni, V, Wiberg, M, Lundgren Willesen, J, Hanås, S, Mcentee, K, Tiret, L, Häggström, J, Lohi, H, Chetboul, V, Fredholm, M, Seppälä, EH, Lequarré, A & Merveille, A 2018, 'Interbreed variation of biomarkers of lipid and glucose metabolism in dogs', Veterinary Clinical Pathology, vol. 47, no. 4, pp. 582-588. https://doi.org/10.1111/vcp.12673

@article{8893373a2769412c93afa77f81c11271,

title = "Interbreed variation of biomarkers of lipid and glucose metabolism in dogs",

abstract = "BackgroundMarkers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species‐specific reference intervals, but interbreed variation can also affect data interpretation.ObjectivesThe purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds.MethodsWe analyzed a database containing information on biochemical variables from 534 dogs belonging to nine different breeds. All dogs were confirmed to be healthy based on history, physical examination, and ancillary tests. Concentrations of glucose, fructosamine, insulin, cholesterol, triglycerides, fatty acids, and C‐reactive protein were compared using the nonparametric Kruskal–Wallis and Dunn's tests.ResultsAll variables tested showed significant interbreed differences, although all breeds remained within the previously established RIs for dogs. Fructosamine, insulin, and cholesterol showed a wide interbreed variation that could affect the interpretation of results.ConclusionsBreed is an important factor to consider when assessing energy metabolism in dogs, especially for markers like fructosamine, insulin, and cholesterol, which vary considerably among breeds.",

author = "Carlos Gomez-fernandez-blanco and Dominique Peeters and Evelyne Moyse and Fr{\'e}d{\'e}ric Farnir and Katja H{\"o}glund and Vassiliki Gouni and Maria Wiberg and {Lundgren Willesen}, Jakob and Sofia Han{\aa}s and Kathleen Mcentee and Laurent Tiret and Jens H{\"a}ggstr{\"o}m and Hannes Lohi and Val{\'e}rie Chetboul and Merete Fredholm and Sepp{\"a}l{\"a}, {Eija H} and Anne-sophie Lequarr{\'e} and Anne-christine Merveille",

year = "2018",

month = dec,

doi = "10.1111/vcp.12673",

language = "English",

volume = "47",

pages = "582--588",

journal = "Veterinary Clinical Pathology",

issn = "0275-6382",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Interbreed variation of biomarkers of lipid and glucose metabolism in dogs

AU - Gomez-fernandez-blanco, Carlos

AU - Peeters, Dominique

AU - Moyse, Evelyne

AU - Farnir, Frédéric

AU - Höglund, Katja

AU - Gouni, Vassiliki

AU - Wiberg, Maria

AU - Lundgren Willesen, Jakob

AU - Hanås, Sofia

AU - Mcentee, Kathleen

AU - Tiret, Laurent

AU - Häggström, Jens

AU - Lohi, Hannes

AU - Chetboul, Valérie

AU - Fredholm, Merete

AU - Seppälä, Eija H

AU - Lequarré, Anne-sophie

AU - Merveille, Anne-christine

PY - 2018/12

Y1 - 2018/12

N2 - BackgroundMarkers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species‐specific reference intervals, but interbreed variation can also affect data interpretation.ObjectivesThe purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds.MethodsWe analyzed a database containing information on biochemical variables from 534 dogs belonging to nine different breeds. All dogs were confirmed to be healthy based on history, physical examination, and ancillary tests. Concentrations of glucose, fructosamine, insulin, cholesterol, triglycerides, fatty acids, and C‐reactive protein were compared using the nonparametric Kruskal–Wallis and Dunn's tests.ResultsAll variables tested showed significant interbreed differences, although all breeds remained within the previously established RIs for dogs. Fructosamine, insulin, and cholesterol showed a wide interbreed variation that could affect the interpretation of results.ConclusionsBreed is an important factor to consider when assessing energy metabolism in dogs, especially for markers like fructosamine, insulin, and cholesterol, which vary considerably among breeds.

AB - BackgroundMarkers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species‐specific reference intervals, but interbreed variation can also affect data interpretation.ObjectivesThe purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds.MethodsWe analyzed a database containing information on biochemical variables from 534 dogs belonging to nine different breeds. All dogs were confirmed to be healthy based on history, physical examination, and ancillary tests. Concentrations of glucose, fructosamine, insulin, cholesterol, triglycerides, fatty acids, and C‐reactive protein were compared using the nonparametric Kruskal–Wallis and Dunn's tests.ResultsAll variables tested showed significant interbreed differences, although all breeds remained within the previously established RIs for dogs. Fructosamine, insulin, and cholesterol showed a wide interbreed variation that could affect the interpretation of results.ConclusionsBreed is an important factor to consider when assessing energy metabolism in dogs, especially for markers like fructosamine, insulin, and cholesterol, which vary considerably among breeds.

U2 - 10.1111/vcp.12673

DO - 10.1111/vcp.12673

M3 - Journal article

C2 - 30556915

SN - 0275-6382

VL - 47

SP - 582

EP - 588

JO - Veterinary Clinical Pathology

JF - Veterinary Clinical Pathology

IS - 4

ER -

Interbreed variation of biomarkers of lipid and glucose metabolism in dogs

Abstract

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