Interactions between infections and immune-inflammatory cells in type 1 diabetes mellitus and inflammatory bowel diseases: evidences from animal models

M H Claesson; F Nicoletti; S Stosic-Grujicic; A Doria; S Zampieri

Interactions between infections and immune-inflammatory cells in type 1 diabetes mellitus and inflammatory bowel diseases: evidences from animal models

M H Claesson, F Nicoletti, S Stosic-Grujicic, A Doria, S Zampieri

Department of Immunology and Microbiology

5 Citations (Scopus)

Abstract

Type 1 diabetes mellitus (T1D) and inflammatory bowel diseases (IBD) are multifactorial disorders of autoimmune origin.Several microbial agents have been reported to be associated with the development of type 1 diabetes and inflammatory bowel diseases in animal models by different mechanisms. These models which resemble the phenotype of the human disease they mimic, can be very useful to identify important pathogenetic mechanisms, as well as therapeutical targets to treat the disease. This review is focused on the immune inflammatory pathways which are considered to be associated with the pathogenesis T1D and IBD in transgenic mice.

Original language	English
Journal	Clinical and Experimental Rheumatology
Volume	26
Issue number	1 Suppl 48
Pages (from-to)	S8-11
ISSN	0392-856X
Publication status	Published - 2008

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Interactions between infections and immune-inflammatory cells in type 1 diabetes mellitus and inflammatory bowel diseases: evidences from animal models. / Claesson, M H; Nicoletti, F; Stosic-Grujicic, S et al.

In: Clinical and Experimental Rheumatology, Vol. 26, No. 1 Suppl 48, 2008, p. S8-11.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Type 1 diabetes mellitus (T1D) and inflammatory bowel diseases (IBD) are multifactorial disorders of autoimmune origin.Several microbial agents have been reported to be associated with the development of type 1 diabetes and inflammatory bowel diseases in animal models by different mechanisms. These models which resemble the phenotype of the human disease they mimic, can be very useful to identify important pathogenetic mechanisms, as well as therapeutical targets to treat the disease. This review is focused on the immune inflammatory pathways which are considered to be associated with the pathogenesis T1D and IBD in transgenic mice.",

author = "Claesson, {M H} and F Nicoletti and S Stosic-Grujicic and A Doria and S Zampieri",

note = "Keywords: Animals; Dendritic Cells; Diabetes Mellitus, Type 1; Disease Models, Animal; Infection; Inflammatory Bowel Diseases; T-Lymphocytes, Regulatory",

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AU - Claesson, M H

AU - Nicoletti, F

AU - Stosic-Grujicic, S

AU - Doria, A

AU - Zampieri, S

N1 - Keywords: Animals; Dendritic Cells; Diabetes Mellitus, Type 1; Disease Models, Animal; Infection; Inflammatory Bowel Diseases; T-Lymphocytes, Regulatory

PY - 2008

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N2 - Type 1 diabetes mellitus (T1D) and inflammatory bowel diseases (IBD) are multifactorial disorders of autoimmune origin.Several microbial agents have been reported to be associated with the development of type 1 diabetes and inflammatory bowel diseases in animal models by different mechanisms. These models which resemble the phenotype of the human disease they mimic, can be very useful to identify important pathogenetic mechanisms, as well as therapeutical targets to treat the disease. This review is focused on the immune inflammatory pathways which are considered to be associated with the pathogenesis T1D and IBD in transgenic mice.

AB - Type 1 diabetes mellitus (T1D) and inflammatory bowel diseases (IBD) are multifactorial disorders of autoimmune origin.Several microbial agents have been reported to be associated with the development of type 1 diabetes and inflammatory bowel diseases in animal models by different mechanisms. These models which resemble the phenotype of the human disease they mimic, can be very useful to identify important pathogenetic mechanisms, as well as therapeutical targets to treat the disease. This review is focused on the immune inflammatory pathways which are considered to be associated with the pathogenesis T1D and IBD in transgenic mice.

M3 - Journal article

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SP - S8-11

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JF - Clinical and Experimental Rheumatology

IS - 1 Suppl 48

ER -

Interactions between infections and immune-inflammatory cells in type 1 diabetes mellitus and inflammatory bowel diseases: evidences from animal models

Abstract

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