Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial

Nina Rica Wium Geiker; Khin Swe Myint; Patrick Heck; Ketan Dhatariya; Sisse Marie Hørup Larsen; Malene Rohr Andersen; Steen Stender; Christian Torp-Pedersen; Nick Finer; Arne Astrup

Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial

Nina Rica Wium Geiker, Khin Swe Myint, Patrick Heck, Ketan Dhatariya, Sisse Marie Hørup Larsen, Malene Rohr Andersen, Steen Stender, Christian Torp-Pedersen, Nick Finer, Arne Astrup

Obesity Research

Abstract

Aims: The risk of heart failure (HF) increases with BMI, but paradoxically obesity has been associated with reduced mortality in patients with HF. The effect of intentional or therapeutic weight loss on HF is not well known. We examined the effect of weight loss induced by low energy diet (LED) on physical performance and cardiovascular risk factors in obese patients with moderate-to-severe HF and/or ischaemic heart disease (IHD).

Methods and Results: Results from two weight loss interventions at two centres, one in Denmark (DK - 12 week intervention in 21 subjects (14 LED, 7 controls)) and one in UK, (16 week intervention in 11 subjects (all LED, no controls) were
combined for a total of 32 subjects with HF or IHD and median BMI 36.2 kg/m2 (range 30-50). Weight loss was initiated with LED (800 kcal/day) followed by energy restricted and protein-rich diet (1200 kcal/day). Physical performance was
measured by six-minute walk test (DK) and maximum oxygen uptake (UK). The effect of treatment was analysed using linear mixed model. Weight loss in the intervention group: 13.9kg ± 6.5 and 1.21kg ± 1.8 in controls (P=0.000). Physical performance (the primary outcome) was improved by 17.8% ± 23.1 in the intervention group versus -22.1% ± 25.6 in the control group (P=0.000). Treatment also improved triglycerides (P=0.000), very low lipoprotein (P=0.001) and C-reactive protein (P=0.010).

Conclusion: Weight loss induced by LED in obese patients with moderate-to-severe HF or IHD resulted in clinically significant improvement in physical performance and cardiovascular risk markers.

Original language	English
Article number	003
Journal	Jacobs Journal of Food and Nutrition
Volume	1
Issue number	1
Number of pages	9
ISSN	2376-9211
Publication status	Published - 2014

Keywords

Faculty of Science
Heart failure
Ischaemic heart disease
Weight loss
Maximum oxygen uptake
Six Minutes Walk Test

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://media.jacobspublishers.com/FoodNutrition/J_J_Food_Nutri_1_1_003.pdfLicence: Unspecified

Cite this

Geiker, N. R. W., Myint, K. S., Heck, P., Dhatariya, K., Larsen, S. M. H., Andersen, M. R., Stender, S., Torp-Pedersen, C., Finer, N., & Astrup, A. (2014). Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial. Jacobs Journal of Food and Nutrition, 1(1), [003]. http://media.jacobspublishers.com/FoodNutrition/J_J_Food_Nutri_1_1_003.pdf

Geiker, NRW, Myint, KS, Heck, P, Dhatariya, K, Larsen, SMH, Andersen, MR, Stender, S, Torp-Pedersen, C, Finer, N & Astrup, A 2014, 'Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial', Jacobs Journal of Food and Nutrition, vol. 1, no. 1, 003. <http://media.jacobspublishers.com/FoodNutrition/J_J_Food_Nutri_1_1_003.pdf>

@article{b88c0462d9634a4782e33884cb52ab04,

title = "Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial",

abstract = "Aims: The risk of heart failure (HF) increases with BMI, but paradoxically obesity has been associated with reduced mortality in patients with HF. The effect of intentional or therapeutic weight loss on HF is not well known. We examined the effect of weight loss induced by low energy diet (LED) on physical performance and cardiovascular risk factors in obese patients with moderate-to-severe HF and/or ischaemic heart disease (IHD).Methods and Results: Results from two weight loss interventions at two centres, one in Denmark (DK - 12 week intervention in 21 subjects (14 LED, 7 controls)) and one in UK, (16 week intervention in 11 subjects (all LED, no controls) werecombined for a total of 32 subjects with HF or IHD and median BMI 36.2 kg/m2 (range 30-50). Weight loss was initiated with LED (800 kcal/day) followed by energy restricted and protein-rich diet (1200 kcal/day). Physical performance wasmeasured by six-minute walk test (DK) and maximum oxygen uptake (UK). The effect of treatment was analysed using linear mixed model. Weight loss in the intervention group: 13.9kg ± 6.5 and 1.21kg ± 1.8 in controls (P=0.000). Physical performance (the primary outcome) was improved by 17.8% ± 23.1 in the intervention group versus -22.1% ± 25.6 in the control group (P=0.000). Treatment also improved triglycerides (P=0.000), very low lipoprotein (P=0.001) and C-reactive protein (P=0.010).Conclusion: Weight loss induced by LED in obese patients with moderate-to-severe HF or IHD resulted in clinically significant improvement in physical performance and cardiovascular risk markers.",

keywords = "Faculty of Science, Heart failure, Ischaemic heart disease, Weight loss, Maximum oxygen uptake, Six Minutes Walk Test",

author = "Geiker, {Nina Rica Wium} and Myint, {Khin Swe} and Patrick Heck and Ketan Dhatariya and Larsen, {Sisse Marie H{\o}rup} and Andersen, {Malene Rohr} and Steen Stender and Christian Torp-Pedersen and Nick Finer and Arne Astrup",

note = "CURIS 2014 NEXS 427",

year = "2014",

language = "English",

volume = "1",

journal = "Jacobs Journal of Food and Nutrition",

issn = "2376-9211",

number = "1",

}

TY - JOUR

T1 - Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial

AU - Geiker, Nina Rica Wium

AU - Myint, Khin Swe

AU - Heck, Patrick

AU - Dhatariya, Ketan

AU - Larsen, Sisse Marie Hørup

AU - Andersen, Malene Rohr

AU - Stender, Steen

AU - Torp-Pedersen, Christian

AU - Finer, Nick

AU - Astrup, Arne

N1 - CURIS 2014 NEXS 427

PY - 2014

Y1 - 2014

N2 - Aims: The risk of heart failure (HF) increases with BMI, but paradoxically obesity has been associated with reduced mortality in patients with HF. The effect of intentional or therapeutic weight loss on HF is not well known. We examined the effect of weight loss induced by low energy diet (LED) on physical performance and cardiovascular risk factors in obese patients with moderate-to-severe HF and/or ischaemic heart disease (IHD).Methods and Results: Results from two weight loss interventions at two centres, one in Denmark (DK - 12 week intervention in 21 subjects (14 LED, 7 controls)) and one in UK, (16 week intervention in 11 subjects (all LED, no controls) werecombined for a total of 32 subjects with HF or IHD and median BMI 36.2 kg/m2 (range 30-50). Weight loss was initiated with LED (800 kcal/day) followed by energy restricted and protein-rich diet (1200 kcal/day). Physical performance wasmeasured by six-minute walk test (DK) and maximum oxygen uptake (UK). The effect of treatment was analysed using linear mixed model. Weight loss in the intervention group: 13.9kg ± 6.5 and 1.21kg ± 1.8 in controls (P=0.000). Physical performance (the primary outcome) was improved by 17.8% ± 23.1 in the intervention group versus -22.1% ± 25.6 in the control group (P=0.000). Treatment also improved triglycerides (P=0.000), very low lipoprotein (P=0.001) and C-reactive protein (P=0.010).Conclusion: Weight loss induced by LED in obese patients with moderate-to-severe HF or IHD resulted in clinically significant improvement in physical performance and cardiovascular risk markers.

AB - Aims: The risk of heart failure (HF) increases with BMI, but paradoxically obesity has been associated with reduced mortality in patients with HF. The effect of intentional or therapeutic weight loss on HF is not well known. We examined the effect of weight loss induced by low energy diet (LED) on physical performance and cardiovascular risk factors in obese patients with moderate-to-severe HF and/or ischaemic heart disease (IHD).Methods and Results: Results from two weight loss interventions at two centres, one in Denmark (DK - 12 week intervention in 21 subjects (14 LED, 7 controls)) and one in UK, (16 week intervention in 11 subjects (all LED, no controls) werecombined for a total of 32 subjects with HF or IHD and median BMI 36.2 kg/m2 (range 30-50). Weight loss was initiated with LED (800 kcal/day) followed by energy restricted and protein-rich diet (1200 kcal/day). Physical performance wasmeasured by six-minute walk test (DK) and maximum oxygen uptake (UK). The effect of treatment was analysed using linear mixed model. Weight loss in the intervention group: 13.9kg ± 6.5 and 1.21kg ± 1.8 in controls (P=0.000). Physical performance (the primary outcome) was improved by 17.8% ± 23.1 in the intervention group versus -22.1% ± 25.6 in the control group (P=0.000). Treatment also improved triglycerides (P=0.000), very low lipoprotein (P=0.001) and C-reactive protein (P=0.010).Conclusion: Weight loss induced by LED in obese patients with moderate-to-severe HF or IHD resulted in clinically significant improvement in physical performance and cardiovascular risk markers.

KW - Faculty of Science

KW - Heart failure

KW - Ischaemic heart disease

KW - Weight loss

KW - Maximum oxygen uptake

KW - Six Minutes Walk Test

M3 - Journal article

SN - 2376-9211

VL - 1

JO - Jacobs Journal of Food and Nutrition

JF - Jacobs Journal of Food and Nutrition

IS - 1

M1 - 003

ER -

Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this