Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort

Cecilie Kyrø; Guri Skeie; Steffen Loft; Rikard Landberg; Jane Hvarregaard Christensen; Eiliv Lund; Lena M Nilsson; Richard Palmqvist; Anne Tjønneland; Anja Olsen

doi:10.1007/s10552-013-0215-z

Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort

Cecilie Kyrø, Guri Skeie, Steffen Loft, Rikard Landberg, Jane Hvarregaard Christensen, Eiliv Lund, Lena M Nilsson, Richard Palmqvist, Anne Tjønneland, Anja Olsen

Section of Environmental Health

53 Citations (Scopus)

Abstract

Purpose: A high intake of whole grains has been associated with a lower incidence of colorectal cancer, but few studies are available on the association with whole grains from different cereals, for example, wheat, rye and oats, and none has addressed these separately. The objective of this study was to investigate the association between whole-grain intake and colorectal cancer. Method: We used data from the large population-based Scandinavian cohort HELGA consisting of 108,000 Danish, Swedish, and Norwegian persons, of whom 1,123 developed colorectal cancer during a median of 11 years of follow-up. Detailed information on daily intake of whole-grain products, including whole-grain bread, crispbread, and breakfast cereals, was available, and intakes of total whole grains and specific whole-grain species (wheat, rye, and oats) were estimated. Associations between these whole-grain variables and the incidence of colorectal cancer were investigated using Cox proportional hazards models. Intake of whole-grain products was associated with a lower incidence of colorectal cancer per 50-g increment (incidence rate ratio [IRR], 0.94; 95 % confidence interval [CI], 0.89, 0.99), and the same tendency was found for total whole-grain intake (IRR pr. 25-g increment, 0.94; 95 % CI, 0.88, 1.01). Intake of whole-grain wheat was associated with a lower incidence of colorectal cancer (IRR for highest versus lowest quartile of intake, 0.66; 95 % CI, 0.51, 0.85), but no statistical significant linear trend was observed (p for trend: 0.18). No significant association was found for whole-grain rye or oats. Conclusion: Whole-grain intake was associated with a lower incidence of colorectal cancer.

Original language	English
Journal	Cancer causes & control : CCC
Volume	24
Issue number	7
Pages (from-to)	1363-74
Number of pages	12
ISSN	0957-5243
DOIs	https://doi.org/10.1007/s10552-013-0215-z
Publication status	Published - Jul 2013

Keywords

Adult
Cereals
Cohort Studies
Colorectal Neoplasms
Dietary Fiber
Female
Food Habits
Humans
Incidence
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Scandinavia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10552-013-0215-z

Cite this

@article{0d26d53b05504e8b81f8864f70565b3b,

title = "Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort",

abstract = "Purpose: A high intake of whole grains has been associated with a lower incidence of colorectal cancer, but few studies are available on the association with whole grains from different cereals, for example, wheat, rye and oats, and none has addressed these separately. The objective of this study was to investigate the association between whole-grain intake and colorectal cancer. Method: We used data from the large population-based Scandinavian cohort HELGA consisting of 108,000 Danish, Swedish, and Norwegian persons, of whom 1,123 developed colorectal cancer during a median of 11 years of follow-up. Detailed information on daily intake of whole-grain products, including whole-grain bread, crispbread, and breakfast cereals, was available, and intakes of total whole grains and specific whole-grain species (wheat, rye, and oats) were estimated. Associations between these whole-grain variables and the incidence of colorectal cancer were investigated using Cox proportional hazards models. Intake of whole-grain products was associated with a lower incidence of colorectal cancer per 50-g increment (incidence rate ratio [IRR], 0.94; 95 % confidence interval [CI], 0.89, 0.99), and the same tendency was found for total whole-grain intake (IRR pr. 25-g increment, 0.94; 95 % CI, 0.88, 1.01). Intake of whole-grain wheat was associated with a lower incidence of colorectal cancer (IRR for highest versus lowest quartile of intake, 0.66; 95 % CI, 0.51, 0.85), but no statistical significant linear trend was observed (p for trend: 0.18). No significant association was found for whole-grain rye or oats. Conclusion: Whole-grain intake was associated with a lower incidence of colorectal cancer.",

keywords = "Adult, Cereals, Cohort Studies, Colorectal Neoplasms, Dietary Fiber, Female, Food Habits, Humans, Incidence, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Scandinavia",

author = "Cecilie Kyr{\o} and Guri Skeie and Steffen Loft and Rikard Landberg and Christensen, {Jane Hvarregaard} and Eiliv Lund and Nilsson, {Lena M} and Richard Palmqvist and Anne Tj{\o}nneland and Anja Olsen",

year = "2013",

month = jul,

doi = "10.1007/s10552-013-0215-z",

language = "English",

volume = "24",

pages = "1363--74",

journal = "Cancer Causes & Control",

issn = "0957-5243",

publisher = "Springer",

number = "7",

}

TY - JOUR

T1 - Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort

AU - Kyrø, Cecilie

AU - Skeie, Guri

AU - Loft, Steffen

AU - Landberg, Rikard

AU - Christensen, Jane Hvarregaard

AU - Lund, Eiliv

AU - Nilsson, Lena M

AU - Palmqvist, Richard

AU - Tjønneland, Anne

AU - Olsen, Anja

PY - 2013/7

Y1 - 2013/7

N2 - Purpose: A high intake of whole grains has been associated with a lower incidence of colorectal cancer, but few studies are available on the association with whole grains from different cereals, for example, wheat, rye and oats, and none has addressed these separately. The objective of this study was to investigate the association between whole-grain intake and colorectal cancer. Method: We used data from the large population-based Scandinavian cohort HELGA consisting of 108,000 Danish, Swedish, and Norwegian persons, of whom 1,123 developed colorectal cancer during a median of 11 years of follow-up. Detailed information on daily intake of whole-grain products, including whole-grain bread, crispbread, and breakfast cereals, was available, and intakes of total whole grains and specific whole-grain species (wheat, rye, and oats) were estimated. Associations between these whole-grain variables and the incidence of colorectal cancer were investigated using Cox proportional hazards models. Intake of whole-grain products was associated with a lower incidence of colorectal cancer per 50-g increment (incidence rate ratio [IRR], 0.94; 95 % confidence interval [CI], 0.89, 0.99), and the same tendency was found for total whole-grain intake (IRR pr. 25-g increment, 0.94; 95 % CI, 0.88, 1.01). Intake of whole-grain wheat was associated with a lower incidence of colorectal cancer (IRR for highest versus lowest quartile of intake, 0.66; 95 % CI, 0.51, 0.85), but no statistical significant linear trend was observed (p for trend: 0.18). No significant association was found for whole-grain rye or oats. Conclusion: Whole-grain intake was associated with a lower incidence of colorectal cancer.

AB - Purpose: A high intake of whole grains has been associated with a lower incidence of colorectal cancer, but few studies are available on the association with whole grains from different cereals, for example, wheat, rye and oats, and none has addressed these separately. The objective of this study was to investigate the association between whole-grain intake and colorectal cancer. Method: We used data from the large population-based Scandinavian cohort HELGA consisting of 108,000 Danish, Swedish, and Norwegian persons, of whom 1,123 developed colorectal cancer during a median of 11 years of follow-up. Detailed information on daily intake of whole-grain products, including whole-grain bread, crispbread, and breakfast cereals, was available, and intakes of total whole grains and specific whole-grain species (wheat, rye, and oats) were estimated. Associations between these whole-grain variables and the incidence of colorectal cancer were investigated using Cox proportional hazards models. Intake of whole-grain products was associated with a lower incidence of colorectal cancer per 50-g increment (incidence rate ratio [IRR], 0.94; 95 % confidence interval [CI], 0.89, 0.99), and the same tendency was found for total whole-grain intake (IRR pr. 25-g increment, 0.94; 95 % CI, 0.88, 1.01). Intake of whole-grain wheat was associated with a lower incidence of colorectal cancer (IRR for highest versus lowest quartile of intake, 0.66; 95 % CI, 0.51, 0.85), but no statistical significant linear trend was observed (p for trend: 0.18). No significant association was found for whole-grain rye or oats. Conclusion: Whole-grain intake was associated with a lower incidence of colorectal cancer.

KW - Adult

KW - Cereals

KW - Cohort Studies

KW - Colorectal Neoplasms

KW - Dietary Fiber

KW - Female

KW - Food Habits

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Proportional Hazards Models

KW - Risk Factors

KW - Scandinavia

U2 - 10.1007/s10552-013-0215-z

DO - 10.1007/s10552-013-0215-z

M3 - Journal article

C2 - 23624874

SN - 0957-5243

VL - 24

SP - 1363

EP - 1374

JO - Cancer Causes & Control

JF - Cancer Causes & Control

IS - 7

ER -

Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this