Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study

Sofus C Larsen; Lars Ängquist; Jane N Østergaard; Tarun Veer Singh Ahluwalia; Karani S Vimaleswaran; Nina Roswall; Lotte M Mortensen; Birgit M. Nielsen; Anne Tjønneland; Nicholas J Wareham; Domenico Palli; Giovanna Masala; Wim Hm Saris; Daphne L van der A; Jolanda Ma Boer; Edith Jm Feskens; Heiner Boeing; Marianne U. Jakobsen; Ruth Jf Loos; Thorkild Ia Sørensen; Kim Overvad

doi:10.3945/jn.115.219675

Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study

Sofus C Larsen, Lars Ängquist, Jane N Østergaard, Tarun Veer Singh Ahluwalia, Karani S Vimaleswaran, Nina Roswall, Lotte M Mortensen, Birgit M. Nielsen, Anne Tjønneland, Nicholas J Wareham, Domenico Palli, Giovanna Masala, Wim Hm Saris, Daphne L van der A, Jolanda Ma Boer, Edith Jm Feskens, Heiner Boeing, Marianne U. Jakobsen, Ruth Jf Loos, Thorkild Ia SørensenKim Overvad

Department of Public Health

2 Citations (Scopus)

Abstract

BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association.

OBJECTIVES: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat, polyunsaturated fat, or saturated fat has a modifying effect on these associations.

METHODS: A case-noncase study included 11,048 men and women from cohorts in the European Diet, Obesity and Genes study; 5552 were cases, defined as individuals with the greatest BW gain during follow-up, and 6548 were randomly selected, including 5496 noncases. We selected 4 genes [CCAAT/enhancer binding protein β (CEBPB), phosphoenolpyruvate carboxykinase 2, PPARγ gene (PPARG), and sterol regulatory element binding transcription factor 1] according to evidence about biologic plausibility for interactions with dietary fat in weight regulation. Diet was assessed at baseline, and anthropometry was followed for 7 y.

RESULTS: The ORs for being a BW gainer for the 27 genetic variants ranged from 0.87 (95% CI: 0.79, 1.03) to 1.12 (95% CI: 0.96, 1.22) per additional minor allele. Uncorrected, CEBPB rs4253449 had a significant interaction with the intake of total fat and subgroups of fat. The OR for being a BW gainer for each additional rs4253449 minor allele per 100 kcal higher total fat intake was 1.07 (95% CI: 1.02, 1.12; P = 0.008), and similar associations were found for subgroups of fat.

CONCLUSIONS: Among European men and women, the influence of dietary fat on associations between SNPs in the PPARγ pathway and anthropometry is likely to be absent or marginal. The observed interaction between rs4253449 and dietary fat needs confirmation.

Original language	English
Journal	Journal of Nutrition
Volume	146
Issue number	3
Pages (from-to)	603-611
ISSN	0022-3166
DOIs	https://doi.org/10.3945/jn.115.219675
Publication status	Published - 1 Mar 2016

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Larsen, S. C., Ängquist, L., Østergaard, J. N., Ahluwalia, T. V. S., Vimaleswaran, K. S., Roswall, N., Mortensen, L. M., Nielsen, B. M., Tjønneland, A., Wareham, N. J., Palli, D., Masala, G., Saris, W. H., van der A, D. L., Boer, J. M., Feskens, E. J., Boeing, H., Jakobsen, M. U., Loos, R. J., ... Overvad, K. (2016). Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study. Journal of Nutrition, 146(3), 603-611. https://doi.org/10.3945/jn.115.219675

Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study. / Larsen, Sofus C; Ängquist, Lars; Østergaard, Jane N et al.

In: Journal of Nutrition, Vol. 146, No. 3, 01.03.2016, p. 603-611.

Research output: Contribution to journal › Journal article › Research › peer-review

Larsen, SC, Ängquist, L, Østergaard, JN, Ahluwalia, TVS, Vimaleswaran, KS, Roswall, N, Mortensen, LM, Nielsen, BM, Tjønneland, A, Wareham, NJ, Palli, D, Masala, G, Saris, WH, van der A, DL, Boer, JM, Feskens, EJ, Boeing, H, Jakobsen, MU, Loos, RJ, Sørensen, TI & Overvad, K 2016, 'Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study', Journal of Nutrition, vol. 146, no. 3, pp. 603-611. https://doi.org/10.3945/jn.115.219675

Larsen SC, Ängquist L, Østergaard JN, Ahluwalia TVS, Vimaleswaran KS, Roswall N et al. Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study. Journal of Nutrition. 2016 Mar 1;146(3):603-611. doi: 10.3945/jn.115.219675

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title = "Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study",

abstract = "BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association.OBJECTIVES: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat, polyunsaturated fat, or saturated fat has a modifying effect on these associations.METHODS: A case-noncase study included 11,048 men and women from cohorts in the European Diet, Obesity and Genes study; 5552 were cases, defined as individuals with the greatest BW gain during follow-up, and 6548 were randomly selected, including 5496 noncases. We selected 4 genes [CCAAT/enhancer binding protein β (CEBPB), phosphoenolpyruvate carboxykinase 2, PPARγ gene (PPARG), and sterol regulatory element binding transcription factor 1] according to evidence about biologic plausibility for interactions with dietary fat in weight regulation. Diet was assessed at baseline, and anthropometry was followed for 7 y.RESULTS: The ORs for being a BW gainer for the 27 genetic variants ranged from 0.87 (95% CI: 0.79, 1.03) to 1.12 (95% CI: 0.96, 1.22) per additional minor allele. Uncorrected, CEBPB rs4253449 had a significant interaction with the intake of total fat and subgroups of fat. The OR for being a BW gainer for each additional rs4253449 minor allele per 100 kcal higher total fat intake was 1.07 (95% CI: 1.02, 1.12; P = 0.008), and similar associations were found for subgroups of fat.CONCLUSIONS: Among European men and women, the influence of dietary fat on associations between SNPs in the PPARγ pathway and anthropometry is likely to be absent or marginal. The observed interaction between rs4253449 and dietary fat needs confirmation.",

author = "Larsen, {Sofus C} and Lars {\"A}ngquist and {\O}stergaard, {Jane N} and Ahluwalia, {Tarun Veer Singh} and Vimaleswaran, {Karani S} and Nina Roswall and Mortensen, {Lotte M} and Nielsen, {Birgit M.} and Anne Tj{\o}nneland and Wareham, {Nicholas J} and Domenico Palli and Giovanna Masala and Saris, {Wim Hm} and {van der A}, {Daphne L} and Boer, {Jolanda Ma} and Feskens, {Edith Jm} and Heiner Boeing and Jakobsen, {Marianne U.} and Loos, {Ruth Jf} and S{\o}rensen, {Thorkild Ia} and Kim Overvad",

note = "{\textcopyright} 2016 American Society for Nutrition.",

year = "2016",

month = mar,

day = "1",

doi = "10.3945/jn.115.219675",

language = "English",

volume = "146",

pages = "603--611",

journal = "Journal of Nutrition",

issn = "0022-3166",

publisher = "American Society for Nutrition",

number = "3",

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TY - JOUR

T1 - Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study

AU - Larsen, Sofus C

AU - Ängquist, Lars

AU - Østergaard, Jane N

AU - Ahluwalia, Tarun Veer Singh

AU - Vimaleswaran, Karani S

AU - Roswall, Nina

AU - Mortensen, Lotte M

AU - Nielsen, Birgit M.

AU - Tjønneland, Anne

AU - Wareham, Nicholas J

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Saris, Wim Hm

AU - van der A, Daphne L

AU - Boer, Jolanda Ma

AU - Feskens, Edith Jm

AU - Boeing, Heiner

AU - Jakobsen, Marianne U.

AU - Loos, Ruth Jf

AU - Sørensen, Thorkild Ia

AU - Overvad, Kim

PY - 2016/3/1

Y1 - 2016/3/1

N2 - BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association.OBJECTIVES: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat, polyunsaturated fat, or saturated fat has a modifying effect on these associations.METHODS: A case-noncase study included 11,048 men and women from cohorts in the European Diet, Obesity and Genes study; 5552 were cases, defined as individuals with the greatest BW gain during follow-up, and 6548 were randomly selected, including 5496 noncases. We selected 4 genes [CCAAT/enhancer binding protein β (CEBPB), phosphoenolpyruvate carboxykinase 2, PPARγ gene (PPARG), and sterol regulatory element binding transcription factor 1] according to evidence about biologic plausibility for interactions with dietary fat in weight regulation. Diet was assessed at baseline, and anthropometry was followed for 7 y.RESULTS: The ORs for being a BW gainer for the 27 genetic variants ranged from 0.87 (95% CI: 0.79, 1.03) to 1.12 (95% CI: 0.96, 1.22) per additional minor allele. Uncorrected, CEBPB rs4253449 had a significant interaction with the intake of total fat and subgroups of fat. The OR for being a BW gainer for each additional rs4253449 minor allele per 100 kcal higher total fat intake was 1.07 (95% CI: 1.02, 1.12; P = 0.008), and similar associations were found for subgroups of fat.CONCLUSIONS: Among European men and women, the influence of dietary fat on associations between SNPs in the PPARγ pathway and anthropometry is likely to be absent or marginal. The observed interaction between rs4253449 and dietary fat needs confirmation.

AB - BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association.OBJECTIVES: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat, polyunsaturated fat, or saturated fat has a modifying effect on these associations.METHODS: A case-noncase study included 11,048 men and women from cohorts in the European Diet, Obesity and Genes study; 5552 were cases, defined as individuals with the greatest BW gain during follow-up, and 6548 were randomly selected, including 5496 noncases. We selected 4 genes [CCAAT/enhancer binding protein β (CEBPB), phosphoenolpyruvate carboxykinase 2, PPARγ gene (PPARG), and sterol regulatory element binding transcription factor 1] according to evidence about biologic plausibility for interactions with dietary fat in weight regulation. Diet was assessed at baseline, and anthropometry was followed for 7 y.RESULTS: The ORs for being a BW gainer for the 27 genetic variants ranged from 0.87 (95% CI: 0.79, 1.03) to 1.12 (95% CI: 0.96, 1.22) per additional minor allele. Uncorrected, CEBPB rs4253449 had a significant interaction with the intake of total fat and subgroups of fat. The OR for being a BW gainer for each additional rs4253449 minor allele per 100 kcal higher total fat intake was 1.07 (95% CI: 1.02, 1.12; P = 0.008), and similar associations were found for subgroups of fat.CONCLUSIONS: Among European men and women, the influence of dietary fat on associations between SNPs in the PPARγ pathway and anthropometry is likely to be absent or marginal. The observed interaction between rs4253449 and dietary fat needs confirmation.

U2 - 10.3945/jn.115.219675

DO - 10.3945/jn.115.219675

M3 - Journal article

C2 - 26865646

SN - 0022-3166

VL - 146

SP - 603

EP - 611

JO - Journal of Nutrition

JF - Journal of Nutrition

IS - 3

ER -