Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation

S.F. Olsen; Harald S. Hansen; T.I. Sørensen; B. Jensen; N.J. Secher; S. Sommer; L.B. Knudsen

Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation

S.F. Olsen, Harald S. Hansen, T.I. Sørensen, B. Jensen, N.J. Secher, S. Sommer, L.B. Knudsen

Department of Public Health

186 Citations (Scopus)

Abstract

Birthweights in the Faroe Islands are among the highest in the world. Compared with Denmark, the average birthweight of liveborn singleton infants of primiparous mothers in 194 g higher, and a substantial part of this difference seems to be attributable to longer gestation. Prostaglandins play an important part in the timing of parturition in human beings. Dietary (n-3)-polyunsaturated fatty acids (PUFA) in high amounts influence endogenous prostaglandin metabolism. Owing to the large consumption of marine fat, the average intake of (n-3)-PUFA in the Faroes by far exceeds that in Denmark. The hypothesis proposed is that dietary (n-3)-PUFA in high amounts prolong gestation in human beings by interfering with uterine production of prostaglandins, possibly by inhibiting the production of dienoic prostaglandins, primarily PGF(2a) and PGE, which are mediators of uterine contractions and cervical ripening.

Original language	English
Journal	Lancet
Volume	2
Issue number	8503
Pages (from-to)	367-369
Number of pages	3
ISSN	0140-6736
Publication status	Published - 1 Jan 1986

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abstract = "Birthweights in the Faroe Islands are among the highest in the world. Compared with Denmark, the average birthweight of liveborn singleton infants of primiparous mothers in 194 g higher, and a substantial part of this difference seems to be attributable to longer gestation. Prostaglandins play an important part in the timing of parturition in human beings. Dietary (n-3)-polyunsaturated fatty acids (PUFA) in high amounts influence endogenous prostaglandin metabolism. Owing to the large consumption of marine fat, the average intake of (n-3)-PUFA in the Faroes by far exceeds that in Denmark. The hypothesis proposed is that dietary (n-3)-PUFA in high amounts prolong gestation in human beings by interfering with uterine production of prostaglandins, possibly by inhibiting the production of dienoic prostaglandins, primarily PGF(2a) and PGE, which are mediators of uterine contractions and cervical ripening.",

author = "S.F. Olsen and Hansen, {Harald S.} and T.I. S{\o}rensen and B. Jensen and N.J. Secher and S. Sommer and L.B. Knudsen",

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TY - JOUR

T1 - Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation

AU - Olsen, S.F.

AU - Hansen, Harald S.

AU - Sørensen, T.I.

AU - Jensen, B.

AU - Secher, N.J.

AU - Sommer, S.

AU - Knudsen, L.B.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Birthweights in the Faroe Islands are among the highest in the world. Compared with Denmark, the average birthweight of liveborn singleton infants of primiparous mothers in 194 g higher, and a substantial part of this difference seems to be attributable to longer gestation. Prostaglandins play an important part in the timing of parturition in human beings. Dietary (n-3)-polyunsaturated fatty acids (PUFA) in high amounts influence endogenous prostaglandin metabolism. Owing to the large consumption of marine fat, the average intake of (n-3)-PUFA in the Faroes by far exceeds that in Denmark. The hypothesis proposed is that dietary (n-3)-PUFA in high amounts prolong gestation in human beings by interfering with uterine production of prostaglandins, possibly by inhibiting the production of dienoic prostaglandins, primarily PGF(2a) and PGE, which are mediators of uterine contractions and cervical ripening.

AB - Birthweights in the Faroe Islands are among the highest in the world. Compared with Denmark, the average birthweight of liveborn singleton infants of primiparous mothers in 194 g higher, and a substantial part of this difference seems to be attributable to longer gestation. Prostaglandins play an important part in the timing of parturition in human beings. Dietary (n-3)-polyunsaturated fatty acids (PUFA) in high amounts influence endogenous prostaglandin metabolism. Owing to the large consumption of marine fat, the average intake of (n-3)-PUFA in the Faroes by far exceeds that in Denmark. The hypothesis proposed is that dietary (n-3)-PUFA in high amounts prolong gestation in human beings by interfering with uterine production of prostaglandins, possibly by inhibiting the production of dienoic prostaglandins, primarily PGF(2a) and PGE, which are mediators of uterine contractions and cervical ripening.

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M3 - Journal article

AN - SCOPUS:0022509024

SN - 0140-6736

VL - 2

SP - 367

EP - 369

JO - Lancet

JF - Lancet

IS - 8503

ER -

Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation

Abstract

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