Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort

Louise Hansen; Guri Skeie; Rikard Landberg; Eiliv Lund; Richard Palmqvist; Ingegerd Johansson; Lars Ove Dragsted; Rikke Egeberg; Nina F Johnsen; Jane Christensen; Kim Overvad; Anne Tjønneland; Anja Olsen

doi:10.1002/ijc.26381

Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort

Louise Hansen, Guri Skeie, Rikard Landberg, Eiliv Lund, Richard Palmqvist, Ingegerd Johansson, Lars Ove Dragsted, Rikke Egeberg, Nina F Johnsen, Jane Christensen, Kim Overvad, Anne Tjønneland, Anja Olsen

58 Citations (Scopus)

Abstract

The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.

Original language	English
Journal	International Journal of Cancer
Volume	131
Issue number	2
Pages (from-to)	469-478
Number of pages	10
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.26381
Publication status	Published - 15 Jul 2012

Keywords

Adult
Cereals
Cohort Studies
Colonic Neoplasms
Dietary Fiber
Eating
Female
Food Habits
Fruit
Humans
Incidence
Male
Middle Aged
Rectal Neoplasms
Risk Factors
Scandinavia
Vegetables

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hansen, L., Skeie, G., Landberg, R., Lund, E., Palmqvist, R., Johansson, I., Dragsted, L. O., Egeberg, R., Johnsen, N. F., Christensen, J., Overvad, K., Tjønneland, A., & Olsen, A. (2012). Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. International Journal of Cancer, 131(2), 469-478. https://doi.org/10.1002/ijc.26381

Hansen, L, Skeie, G, Landberg, R, Lund, E, Palmqvist, R, Johansson, I, Dragsted, LO, Egeberg, R, Johnsen, NF, Christensen, J, Overvad, K, Tjønneland, A & Olsen, A 2012, 'Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort', International Journal of Cancer, vol. 131, no. 2, pp. 469-478. https://doi.org/10.1002/ijc.26381

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title = "Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort",

abstract = "The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.",

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author = "Louise Hansen and Guri Skeie and Rikard Landberg and Eiliv Lund and Richard Palmqvist and Ingegerd Johansson and Dragsted, {Lars Ove} and Rikke Egeberg and Johnsen, {Nina F} and Jane Christensen and Kim Overvad and Anne Tj{\o}nneland and Anja Olsen",

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year = "2012",

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doi = "10.1002/ijc.26381",

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T1 - Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort

AU - Hansen, Louise

AU - Skeie, Guri

AU - Landberg, Rikard

AU - Lund, Eiliv

AU - Palmqvist, Richard

AU - Johansson, Ingegerd

AU - Dragsted, Lars Ove

AU - Egeberg, Rikke

AU - Johnsen, Nina F

AU - Christensen, Jane

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Olsen, Anja

N1 - IHE 2012 075

PY - 2012/7/15

Y1 - 2012/7/15

N2 - The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.

AB - The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.

KW - Adult

KW - Cereals

KW - Cohort Studies

KW - Colonic Neoplasms

KW - Dietary Fiber

KW - Eating

KW - Female

KW - Food Habits

KW - Fruit

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Rectal Neoplasms

KW - Risk Factors

KW - Scandinavia

KW - Vegetables

U2 - 10.1002/ijc.26381

DO - 10.1002/ijc.26381

M3 - Journal article

C2 - 21866547

SN - 0020-7136

VL - 131

SP - 469

EP - 478

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 2

ER -

Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort

Abstract

Keywords

UN SDGs

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