TY - JOUR
T1 - Insulin resistance and beta-cell function in different ethnic groups in Kenya
T2 - the role of abdominal fat distribution
AU - Christensen, Dirk Lund
AU - Faurholt-Jepsen, Daniel
AU - Færch, Kristine
AU - Mwaniki, D L
AU - Boit, M K
AU - Kilonzo, B
AU - Tetens, Inge
AU - Friis, Henrik
AU - Borch-Johnsen, Knut
N1 - CURIS 2014 NEXS 038
PY - 2014/2
Y1 - 2014/2
N2 - Little is known about the pathophysiology of diabetes in Africans. Thus, we assessed whether insulin resistance and beta-cell function differed by ethnicity in Kenya and whether differences were modified by abdominal fat distribution. A cross-sectional study in 1,087 rural Luo (n = 361), Kamba (n = 378), and Maasai (n = 348) was conducted. All participants had a standard 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected at 0, 30, and 120 min. Serum insulin was analysed at 0 and 30 min. From the OGTT, we assessed the homoeostasis model assessment of insulin resistance by computer model, early phase insulin secretion, and disposition index (DI) dividing insulin secretion by insulin resistance. Abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) thickness were carried out by ultrasonography. Linear regression analyses were done to assess ethnic differences in insulin indices. The Maasai had 32 and 17 % higher insulin resistance than the Luo and Kamba, respectively (p
AB - Little is known about the pathophysiology of diabetes in Africans. Thus, we assessed whether insulin resistance and beta-cell function differed by ethnicity in Kenya and whether differences were modified by abdominal fat distribution. A cross-sectional study in 1,087 rural Luo (n = 361), Kamba (n = 378), and Maasai (n = 348) was conducted. All participants had a standard 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected at 0, 30, and 120 min. Serum insulin was analysed at 0 and 30 min. From the OGTT, we assessed the homoeostasis model assessment of insulin resistance by computer model, early phase insulin secretion, and disposition index (DI) dividing insulin secretion by insulin resistance. Abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) thickness were carried out by ultrasonography. Linear regression analyses were done to assess ethnic differences in insulin indices. The Maasai had 32 and 17 % higher insulin resistance than the Luo and Kamba, respectively (p
U2 - 10.1007/s00592-013-0474-x
DO - 10.1007/s00592-013-0474-x
M3 - Journal article
C2 - 23563691
SN - 0940-5429
VL - 51
SP - 53
EP - 60
JO - Acta Diabetologica
JF - Acta Diabetologica
IS - 1
ER -
