Insulin requirements in type 1 diabetic pregnancy: do twin pregnant women require twice as much insulin as singleton pregnant women?

TY - JOUR

T1 - Insulin requirements in type 1 diabetic pregnancy

T2 - do twin pregnant women require twice as much insulin as singleton pregnant women?

AU - Callesen, Nicoline

AU - Ringholm, Lene

AU - Stage, Edna

AU - Damm, Peter

AU - Mathiesen, Elisabeth R

PY - 2012/6

Y1 - 2012/6

N2 - OBJECTIVE - To evaluate the insulin requirements in women with type 1 diabetes during twin pregnancy compared with singleton pregnancy. RESEARCH DESIGN AND METHODS - At 8, 14, 21, 27, and 33 gestational weeks, insulin requirements and HbA 1c were compared between 15 twin pregnant women from 2000 to 2011 and 108 singleton pregnant women from 2004 to 2006. RESULTS - In twin pregnancies, the weekly increase in daily insulin dose between 14 and 27 weeks was higher than in singleton pregnancies (median 3.0 international units [IU] [range 0.9-4.9] versus 1.5 IU [21.5 to 5.9]; P = 0.008) and remained stable from 27 to 33 weeks. The increment in total insulin requirement from before pregnancy until 33 weeks tended to be higher in twin pregnancies (103% [36-257%] versus 71% [-20 to 276%]; P = 0.07). Throughout pregnancy, HbA 1c was similar in twin and singleton pregnancies. CONCLUSIONS - In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies.

AB - OBJECTIVE - To evaluate the insulin requirements in women with type 1 diabetes during twin pregnancy compared with singleton pregnancy. RESEARCH DESIGN AND METHODS - At 8, 14, 21, 27, and 33 gestational weeks, insulin requirements and HbA 1c were compared between 15 twin pregnant women from 2000 to 2011 and 108 singleton pregnant women from 2004 to 2006. RESULTS - In twin pregnancies, the weekly increase in daily insulin dose between 14 and 27 weeks was higher than in singleton pregnancies (median 3.0 international units [IU] [range 0.9-4.9] versus 1.5 IU [21.5 to 5.9]; P = 0.008) and remained stable from 27 to 33 weeks. The increment in total insulin requirement from before pregnancy until 33 weeks tended to be higher in twin pregnancies (103% [36-257%] versus 71% [-20 to 276%]; P = 0.07). Throughout pregnancy, HbA 1c was similar in twin and singleton pregnancies. CONCLUSIONS - In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies.

U2 - 10.2337/dc11-2467

DO - 10.2337/dc11-2467

M3 - Journal article

C2 - 22432115

SN - 0149-5992

VL - 35

SP - 1246

EP - 1248

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -