Abstract
BACKGROUND: The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).
MATERIALS AND METHODS: Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.
RESULTS: Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.
CONCLUSION: IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.
| Original language | English |
|---|---|
| Journal | Anticancer Research |
| Volume | 34 |
| Issue number | 6 |
| Pages (from-to) | 2991-2996 |
| Number of pages | 6 |
| ISSN | 0250-7005 |
| Publication status | Published - 1 Jun 2014 |
Keywords
- Adenocarcinoma
- Adolescent
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Lung Neoplasms
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- RNA, Messenger
- Real-Time Polymerase Chain Reaction
- Receptor, IGF Type 1
- Reverse Transcriptase Polymerase Chain Reaction
- Survival Rate
- Tumor Markers, Biological
- Young Adult
