Insights into mitotic checkpoint by integrating CRISPR and RNAi

Gang Zhang

doi:10.1080/23723556.2019.1603436

Insights into mitotic checkpoint by integrating CRISPR and RNAi

Gang Zhang

1 Citation (Scopus)

Abstract

Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines expressing low levels of BUB1 protein sufficient to support spindle assembly checkpoint activity. This rings alarm bells on the application of CRISPR technology.

Original language	English
Article number	1603436
Journal	Molecular & Cellular Oncology
Volume	6
Issue number	4
ISSN	2372-3556
DOIs	https://doi.org/10.1080/23723556.2019.1603436
Publication status	Published - 4 Jul 2019

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title = "Insights into mitotic checkpoint by integrating CRISPR and RNAi",

abstract = "Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines expressing low levels of BUB1 protein sufficient to support spindle assembly checkpoint activity. This rings alarm bells on the application of CRISPR technology.",

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AB - Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines expressing low levels of BUB1 protein sufficient to support spindle assembly checkpoint activity. This rings alarm bells on the application of CRISPR technology.

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Insights into mitotic checkpoint by integrating CRISPR and RNAi

Abstract

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